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Modelling and numerical simulation of remodelling processes in cortical bone : An IGA approach to flexoelectricity-induced osteocyte apoptosis and subsequent bone cell diffusion

Remodelling is an important process in bones in order to maintain bone mass and to recover cracks which naturally develop within the bone material. There is agreement in the literature that the piezoelectric characteristic of bones is one possible initiator of bone remodelling. In recent experimental studies, however, it has been found that cortical bone also exhibits flexoelectric properties whic

Prospects for detection of intermediate-mass black holes in globular clusters using integrated-light spectroscopy

The detection of intermediate-mass black holes (IMBHs) in Galactic globular clusters (GCs) has so far been controversial. In order to characterize the effectiveness of integrated-light spectroscopy through integral field units, we analyse realistic mock data generated from state-of-the-art Monte Carlo simulations of GCs with a central IMBH, considering different setups and conditions varying IMBH

Immune functions of intestinal dendritic cells

The intestinal surface is daily challenged with tremendous amount of foreign material derived our diet and from the commensal bacteria that densely populate the mucosal surface. Occasionally the gut mucosa is exposed to pathogens trying to enter our body. The important task of the intestinal immune system is to remain tolerant toward innocuous luminal constituents and to elicit defense responses t

The ecology of the galactic centre : Nuclear stellar clusters and supermassive black holes

Supermassive black holes are found in most galactic nuclei. A large fraction of these nuclei also contain a nuclear stellar cluster surrounding the black hole. Here we consider the idea that the nuclear stellar cluster formed first and that the supermassive black hole grew later. In particular we consider the merger of three stellar clusters to form a nuclear stellar cluster, where some of these c

Estimating major merger rates and spin parameters ab initio via the clustering of critical events

We build a model to predict from first principles the properties of major mergers. We predict these from the coalescence of peaks and saddle points in the vicinity of a given larger peak, as one increases the smoothing scale in the initial linear density field as a proxy for cosmic time. To refine our results, we also ensure, using a suite of ∼400 power-law Gaussian random fields smoothed at ∼30 d

A Healthy Marriage? Marital Status and Adult Mortality

This chapter shows that marital status has had a fairly consistent association with mortality over the entire twentieth century for men. Increasingly, this association was also found among women. Married men have a survival premium today, and the same was true in the past. For men, marriage has been associated with lower mortality throughout the twentieth century and into the twenty-first century,

Sensing Mechanism and Excited-State Dynamics of a Widely Used Intracellular Fluorescent pH Probe : pHrodo

The pHrodo with an “off–on” response to the changes of pH has been widely used as a fluorescent pH probe for bioimaging. The fluorescence off–on mechanism is fundamentally important for its application and further development. Herein, the sensing mechanism, especially the relevant excited-state dynamics, of pHrodo is investigated by steady-state and time-resolved spectroscopy as well as quant

The origin of the Milky Way globular clusters

We present a cosmological zoom-in simulation of a Milky Way-like galaxy used to explore the formation and evolution of star clusters. We investigate in particular the origin of the bimodality observed in the colour and metallicity of globular clusters, and the environmental evolution through cosmic times in the form of tidal tensors. Our results self-consistently confirm previous findings that the

Understanding the shape and diversity of dwarf galaxy rotation curves in ΛCDM

The shape and diversity of dwarf galaxy rotation curves is at apparent odds with dark matter halos in a Λ Cold Dark Matter (ΛCDM) cosmology. We use mock data from isolated dwarf galaxy simulations to show that this owes to three main effects. Firstly, stellar feedback heats dark matter, leading to a `coreNFW' dark matter density profile with a slowly rising rotation curve. Secondly, if close to a

Characterizing gravitational instability in turbulent multicomponent galactic discs

Gravitational instabilities play an important role in galaxy evolution and in shaping the interstellar medium (ISM). The ISM is observed to be highly turbulent, meaning that observables like the gas surface density and velocity dispersion depend on the size of the region over which they are measured. In this work, we investigate, using simulations of Milky Way-like disc galaxies with a resolution

Larson's scaling laws, and the gravitational instability of clumpy discs at high redshift

Gravitational instabilities play a primary role in shaping the clumpy structure and powering the star formation activity of gas-rich high-redshift galaxies. Here, we analyse the stability of such systems, focusing on the size and mass ranges of unstable regions in the disc. Our analysis takes into account the mass-size and linewidth-size scaling relations observed in molecular gas, originally disc

A Toomre-like stability criterion for the clumpy and turbulent interstellar medium

We explore the gravitational instability of clumpy and turbulent gas discs, taking into account the Larson-type scaling laws observed in giant molecular clouds (GMCs) and H i, as well as more general scaling relations. This degree of freedom is of special interest in view of the coming high-z interstellar medium surveys and is thus potentially important for understanding the dynamical effects of t