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Allergic skin diseases caused by low molecular weight chemical compounds are a major health concern among the general population, especially in certain occupational groups. To limit exposure to such compounds, it is important that thorough risk assessments are performed before products reach the consumer market. Traditionally, such risk assessments have been based on animal tests, but due to sever

The post accelerator REX-ISOLDE is installed at the ISOLDE facility at CERN, where a broad variety of radioactive ions can be addressed. Since the end of 2001 beams at the final energy of 2.2 MeV/u are available. REX-ISOLDE uses a unique system of beam bunching and charge breeding. First a Penning trap accumulates and bunches the ions, which are delivered as a quasi-continuous beam from the ISOLDE

Indigestible residues from black beans (B; Phaseolus vulgaris L cv Tacarigua), green beans (G; Phaseolus vulgaris L), carrots (C; Daucus carota L) and rice bran (R; from Oryza saliva L) were prepared by the pepsin/pancreatin method of Hellendoorn et al and their effect on trypsin and pancreatic α‐amylase was evaluated comparing two experimental procedures. When the remaining caseinolytic enzyme ac

As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are attracting significant interest, particularly in relation to identification of peptides displaying potent but selective effects. Much less focus has been placed on delivery systems for AMPs, despite AMPs suffering from delivery challenges related to their size, cationicity,

We provide an overview of current and possible future directions of Applied Statistics and explore choice of topics (e.g., Bioinformatics), paradigms and methodology. We also provide a tentative assessment of special problems arising in analysis of Indian data. Some priorities and need for special care in applied work are suggested, specially in the Indian context.

This chapter focuses on industrialization and family behavior during the twentieth century against the backdrop of economic and institutional change. It documents trends regarding marriage and fertility and union dissolution from a gender perspective, and explores the role of socioeconomic status (SES) for these processes. Findings confirm patterns regarding gender and family consistent with that

Implicit sequence learning (ISL) has been studied using a variety of tasks two of which have been particularly influential: the serial reaction time task (SRTT) and the artificial grammar learning (AGL) task, stemming from the motor learning domain and psycholinguistics, respectively. SRTTs measure the difference in response times between a repeatedly presented and random sequences of keyboard pre

Do you ever hear a medical term (e.g., demoralization) and wonderwhy it wasn’ t discussed in medical school? Do you ever wonderwhether some words or concepts mean the same thing to all practitioners?If you have, then the following case vignette should provide theforum to discuss the evolution of some terms and help you decide how toapply them.

BACKGROUND: The purpose of this study was to estimate precise age-specific tubo-ovarian carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C and RAD51D. METHODS: We analyzed data from 6178 families, 125 with pathogenic variants in RAD51C, and 6690 families, 60 with pathogenic variants in RAD51D. TOC and BC relative and cumulative risks were estimated using com

A 67-year-old, previously fit, woman presented with a history of rectal bleeding.Per rectum examination revealed alow rectal mass, which on endoscopy wasdemonstrated to be submucosal. MR rectumconfirmed a 5 cm rectal mass displacing therectum anteriorly. Chest x-ray and abdominalCT did not reveal any metastatic disease. Biopsies were consistent with high grade gastrointestinal stromal cell tumour

Vocal tract elongation, which uniformly lowers vocal tract resonances (formant frequencies) in animal vocalizations, has evolved independently in several vertebrate groups as a means for vocalizers to exaggerate their apparent body size. Here, we propose that smaller speech-like articulatory movements that alter only individual formants can serve a similar yet less energetically costly size-exagge

The Paleogene history of biogenic opal accumulation in the North Atlantic provides insight into both the evolution of deepwater circulation in the Atlantic basin and weathering responses to major climate shifts. However, existing records are compromised by low temporal resolution and/or stratigraphic discontinuities. In order to address this problem, we present a multi-site, high-resolution record

During the Christianization of the early Slavic realms at the turn of the tenth century, a specific type of noble passion-bearing saint came about. Four saints were promoted in short succession in the western, north-eastern, and south-eastern Slavic realms in the span of less than a hundred years. All four were promoted as noble passion-bearing saints and prototypes of the good Christian ruler. Th

This study attempts to apply computational methods to the Twitter Election Integrity Datasets in order to derive a basic descriptive overview of this disinformation data, and to suggest some possible routes for developing these methods to address future research questions. The results indicate substantial variations in tweet frequency over time and geographical regions, as well as differences in r