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Abstract Work on the design, synthesis, and biological evaluation of galectin inhibitors is presented. The most significant results relate to the development of galactose-based arginine “tweezers” and taloside-based galectin inhibitors. The galectins are a β-galactoside binding protein family. They are involved in cancer and inflammation, thus comprising interesting pharmaceutical targets. Galact
Polyphosphoinositides, the different phosphorylated variants of the phospholipid phosphatidylinositol (PtdIns), are used in a wide array of intracellular mechanisms in eukaryotic cells. The phosphorylation of PtdIns at carbon D4, catalyzed by phosphatidylinositol 4-kinase, is an important step in the synthesis of several of these molecules. The presence of different isoenzymes of PtdIns 4-kinase i
Mot bakgrund av direktiv 1999/70/EG som genomför ramavtalet om visstidsarbete slutet mellan ETUC, UNICE och CEEP har det ifrågasatts om lag (1982:80) om anställningsskydd lever upp till direktivets krav avseende införande av hinder mot att tidsbegränsade anställningsformer missbrukas. Ramavtalet mellan de sociala parterna inriktar sig speciellt på missbruk som uppstår ur användningen av på varandrFollowing the entry into force of Council Directive 1999/70/EC concerning the framework agreement on fixed-term work concluded by ETUC, UNICE and CEEP it has been questioned whether the Swedish Employment Protection Act is in accordance with the directive concerning the introduction of measures to prevent abuse of fixed-term employment contracts. The framework agreement between the social partners
The aim of this Master’s thesis is to study some of the consequences the collaboration model has brought about to public libraries in Skåne. Since the implementation of the model in 2011, the regions have obtained increased responsibilities in terms of both development work and allocation of funds to public libraries in the region. The regional cultural plan states that Kultur Skåne – The Administ
Abstract Almost nothing is known about the Tibetan wolf (Canis lupus chanco) apart from opportunistic anecdotes, notes in journals and conflict with humans. Taxonomic status of this canine has not been investigated so far for Nepal's wild population to state it as Tibetan wolf or Himalayan wolf. Furthermore, persecution of the wolf has been a major issue in the Himalayan region without any det
The hairdresser occupation is classified as probably carcinogenic to humans based on an excess risk for urinary bladder cancer, but it is unclear if current work as a hairdresser entails such a risk. The overall aim of this thesis was to investigate if hairdressers have an ongoing exposure to selected carcinogenic aromatic amines. We recruited 295 hairdressers, 32 consumers of hair dyes and 60 co
Many changes have occurred in the area of immunity for high state officials during the last century. States and their High Representatives, such as Head of State, Head of Government and Foreign Ministers were at the beginning of the last century granted absolute immunities for all acts they conducted. Evolution has, however, produced new rules based more on their need to function properly and less
I Sverige sker överprövning av valfrågor av en av riksdagen utsedd nämnd, Valprövningsnämnden. Valprövningsnämnden består av ordförande och sex ledamöter. Ordföranden ska vara eller ha varit ordinarie domare och får inte vara ledamot av riksdagen. För övriga ledamöter finns inga liknande kompetenskrav eller begränsningar. Samtliga Valprövningsnämnder har bestått av ledamöter med klar partipolitiskIn Sweden, a committee appointed by the Swedish parliament, the Election Review Board, handles the reviewing of electoral issues. The Election Review Board consists of a chairman and six members; the chairman shall be or have been a regular judge and may not be a member of parliament. For the other members there are no similar requirements or limitations. All Election Review Boards have consisted
Which expectations did leading debaters place on fiction as an instrument in achieving societal changes hoped for by introducing the Public library? How can the value of fiction be described in relation to the mission of the Public library, according to these moulders of public opinion? Place and timeframe for this thesis is Sweden around the years 1905-1912 (period of formation of the Public libr
Swedish Match is a global Group of companies with a broad assortment of market-leading brands in smokeless tobacco products, cigars, pipe tobacco and lights products. The South African organization comprises of three individual companies that were acquired between 1999 and 2001. This thesis was focused on two of these three companies, Leonard Dingler and Best Blend with pipe tobacco as the most im
I den svenska arbetsmarknadsmodellen sker kollektiv reglering av arbetsvillkoren genom frivilliga självständiga förhandlingar mellanarbetsmarknadens parter. I denna modell utgör stridsåtgärder det yttersta maktmedlet för arbetstagareorganisationerna, varigenom dessa tillförsäkra sig inflytande över arbetsvillkoren och tillser att ett monopol på arbetskraften upprätthålls. Den svenska rättsordningeThe Swedish labor market model is distinguished by the fact that working conditions are, to a large extent, regulated through voluntary autonomous collective bargaining between management and labor. Strike action and other collective measures constitute the leverage with which the labor organizations can influence working conditions and maintain a monopoly on the supply of labor. To facilitate the
Introduction. Cellfion is a company developing PFAS-free membranes based on chemically functionalized nanocellulose. The membranes are highly tuneable and exhibit favourable properties such as high selectivity, low resistance and low swelling. Cellfion’s membranes have shown potential for use in different applications such as electrodialysis, fuel cells, electrolyzers, humidification syste
BACKGROUND: Mitochondrial dysfunction is a hallmark of cancer. However, it is unclear whether it is a cause of cancer. This two-sample Mendelian randomization (MR) analyses, uses genetic instruments to proxy the exposure of mitochondrial dysfunction and cancer summary statistics as outcomes, allowing for causal inferences.METHODS: Summary statistics from 18 common cancers (2107-491,974 participant
Background: Musculoskeletal pain and its risk factors are rarely assessed in studies on adolescent athletes. The aim was to identify risk factors at baseline that were associated with the persistence or development of musculoskeletal pain at a two-year follow-up in adolescent sport school students, and to study cross-sectional associations at follow-up between musculoskeletal pain and sports perfo
As part of current efforts to work towards sustainable development, find solutions to curb greenhouse gas emissions, and adapt cities to the effects of climate change, such as floods and extreme heat, there are high hopes that nature-based solutions (NBS) can support the transformation needed. Based on the knowledge that implementation and governance of urban NBS is still emerging and constrained
Smooth muscle participates in forming the wall of hollow organs, tracts, and blood vessels. Therefore, it plays a critical role in mediating vital functions in the body including regulation of blood pressure. In response to changes in the surrounding microenvironment, smooth muscle cells can modulate their phenotype and dedifferentiate from being quiescent contractile to a more proliferative and m
How can we understand the multi-ethnic workplace as a social meeting place? And what happens if we do not 'frame' in advance the social meeting in the widespread anti-racist frame of understanding? These are the questions that are central to this thesis. Starting from a phenomenological methodology, it is the ambition of the thesis to challenge our usual preconceptions and not pre-define how inter
Popular Abstract in Swedish Denna avhandling ger en introduktion till laser-plasma acceleratorer, vilket även utgör ämnet för de vetenskapliga artiklar som ingår i avhandlingen. Det är en ny typ av acceleratorer som utnyttjar mycket kraftfulla lasrar för att accelerera elektroner och protoner. Partikelacceleratorer används för att ge partiklar hög rörelseenergi, vilket kan utnyttjas för många olikThis thesis presents experimental results related to laser plasma accelerators. These rely on very different principles from conventional particle accelerators. They are able to accelerate particles over a very short distance and produce synchrotron x-rays at the same time, potentially providing a compact particle accelerator and x-ray source for many future applications. The laser pulses used in
The cholesterol-lowering effect of oats is well established, but the crucial properties eliciting this effect need to be further investigated to optimize the use of oats as functional foods. Furthermore, there are almost no reports investigating the effect of oats on atherosclerosis development. This thesis describes our work with finding suitable mouse models to study cholesterol-lowering and ant
