Filtyp
In modern society, the consumption of fossil fuels has been increasing drastically, leading to significant emissions of carbondioxide (CO2), air pollution, global warming, and political and economic imbalances. This has increased the interest inrenewable and sustainable energy sources such as wind- and hydropower, solar energy, and in energy conversion by fuel celltechnology, and water electrolyse
Aims: Heart failure (HF) is a progressive condition that is becoming more prevalent in the ageing population. Pulmonary hypertension is a common complicating factor in HF and negatively impacts survival. Plasma biomarkers are a potential method for determining the prognosis of patients with left heart failure with pulmonary hypertension (LHF-PH). We aimed to analyse the prognostic capability of 33
The rational for studying health consequences of social determinants is to enable understanding of factors that affect population patterns of health, disease and well-being in order to produce knowledge useful for guiding policies and actions to reduce social inequalities in health and promote social well-being. The aims of this study have been to investigate the association between aspects of soc
Popular Abstract in Swedish De flesta cancerpatienter dör på grund av spridning av tumörceller till olika organ. Invasiv och metastaserande cancer svarar ofta inte på behandling och blir då i många fall dödlig. Leukemi är en elakartad sjukdom av blodceller, som påverkar blod-producerande organ. Den höga förekomsten av leukemi förekommer i äldre befolkningen och hos barn. Leukemi återfall och resiThe majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. Elevated expression of a cell cycle regulator cyclin A1 initiated leukemia
Popular Abstract in English Huntingtons sjukdom (HS), även kallad danssjukan, är en ärftlig och dödlig sjukdom som leder till ofrivilliga motoriska rörelser. Personer med HS får vanligtvis symtom i medelål- dern och avlider efter 15–20 år. Diagnosen ställs klinisk när de första ofrivilliga rörelserna uppträder. Dessa symtom kan kopplas till celldöd i de delar av hjärna som styr vår rörelse. SjukdoHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. The hypothalamus is an area in the brain involved in the regulation of emotions and m
Diabetes mellitus is a disease characterized by increased blood glucose levels. For overt type 2 diabetes to develop, both insulin action and insulin secretion must be perturbed. In the work presented in this thesis, two models were analyzed: hormone-sensitive lipase (HSL) null mice and a pancreatic clonal β-cell line to study the mechanisms underlying insulin resistance and insulin secretion pert
Popular Abstract in Swedish Bakgrund Den medicinska utvecklingen har varit stark under de senaste åren vad gäller akut omhändertagande av patienter med misstänkt hjärtinfarkt. Snabb teknisk utveckling inom området för kateterburen koronarkärlsintervention (PCI) och framsteg inom farmakologisk behandling har bidragit till allt bättre vårdresultat. Omedelbar och korrekt beslutsprocess har kommit attBackground In patients with symptoms compatible with acute myocardial infarction (MI), early triage by ECG in the pre-hospital phase by ST-segment elevation myocardial infarction (STEMI) criteria is important for direct transport of these patients to a regional center for primary percutaneous coronary intervention (pPCI). The time from first medical contact to pPCI should, due to present guideline
Non-state actors have been increasingly engaged in regulation, operating and setting rules outside of, and parallel to, existing legal institutions. These “alternative to legal rules” have been increasingly influential in domestic law and policy, with growing evidence of them penetrating legal, professional, as well as social orders. This thesis adopts the case of sustainability assurance to analy
The interfacial behaviour of polymers in relation to surface modification and polymer degradation was studied. In the first part the interfacial behaviour of amphiphilic poly(ethylene oxide)–poly(D,L-lactide) (EmLn) diblock copolymers at hydrophilic and hydrophobic substrates from aquous solution was studied. All copolymers showed a much higher saturation adsorption compared to that of the poly(et
Background: Attention deficit/hyperactivity disorder (AD/HD) and autism spectrum disorders (ASDs) are early-onset, but often life-time impairing, neurodevelopmental disorders. They are highly overlapping and seem to carry considerable risks of negative outcomes, psychiatrically and psychosocially. Childhood hyperactivity is a known risk factor for early-onset conduct disorder (CD), but details con
Popular Abstract in Swedish Mäns våld mot kvinnor är ett allt mer uppmärksammat folkhälsoproblem och ett brott mot de mänskliga rättigheterna. Kvinnor utsätts för våld i alla länder oberoende av utbildningsnivå och ekonomiska tillgångar. Partnervåld av en nuvarande eller tidigare partner är den vanligaste formen av våld som kvinnor utsätts för. Våld mot kvinnor leder till både negativa mentala ochViolence against women (VAW) is an increasing public health concern. Prevalence of such violence may potentially be greater among foreign-born women due to lack of empowerment and other contributing factors. Research concerning violence against foreign-born women in Sweden is scarce. Thus, the general aim of this thesis was to obtain increased knowledge of exposure to interpersonal violence among
This thesis deals with the empirical testing of trade theories, traditionally used to analyze international trade, using regional data on production and trade. This thesis consists of three main essays. In the first essay, we analyze Swedish regional production. In the first part, we focus on the effects of comparative advantage in predicting regional manufacturing production. In so doing, we use
An accurate molecular diagnosis of diabetes subtype confers clinical benefits; however, many individuals with monogenic diabetes remain undiagnosed. Biomarkers could help to prioritise patients for genetic investigation. We recently demonstrated that high-sensitivity C-reactive protein (hsCRP) levels are lower in UK patients with hepatocyte nuclear factor 1 alpha (HNF1A)-MODY than in other diabete
In the current work, we compared the ability of 17 beta-estradiol (E-2) and the selective estrogen receptor modulators (SERMs), tamoxifen (Tam), raloxifene (Ral) and ospemifene (Osp) to promote the survival of osteoblast-derived cells against etoposide-incluced apoptosis. In order to compare the roles of the two estrogen receptor (ER) isotypes, we created a U2OS human osteosarcoma cell line stably
This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA
The thesis concerns the development and application of two laser-based methods for combustion diagnostics: dual broadband rotational coherent anti-Stokes Raman spectroscopy (CARS) and laser-induced fluorescence (LIF). In efforts to increase the usefulness of the CARS technique, the applicability of a method involving a combination of the rotational CARS technique and the closely related vibration
Mould problems in buildings have become a growing concern during the past decades. The growth of mould fungi indoors deteriorates air quality, influences human health and causes economical losses. Preventing mould growth from occurring is a more cost effective option than cleaning and renovation of buildings with mould problems. Mould growth will occur in buildings when there are moisture problem
This report aims to communicate the process and result of the master’s thesis project that was accomplished at TePe Munhygienprodukter AB, with the title Development of a dental measuring instrument. The project had a timeframe of 18 weeks and consisted to a large extent of generating a foundation for developing a product that allows for simple measuring of interdental spaces. TePe develops denta
Sedan 2004, när förordning 1/2003 trädde ikraft, har kommissionen givits en möjlighet att ersätta sitt förfarande för överträdelsebeslut inom tillämpningen av konkurrensrätt, med ett förenklat förfarande där specifika åtaganden görs bindande gentemot företag. Den huvudsakliga skillnaden ligger i att istället för att behöva genomföra en grundlig utredning gällande ett eller flera företags agerandenAs of 2004, with the entry into force of Regulation 1/2003, the Commission has been granted a possibility to substitute its infringement procedure in competition law enforcement, for a simplified commitment procedure. The major difference lies in that instead of having to conduct a thorough investigation into the behaviour of one or more undertakings, and follow this investigation with a finding o
