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OBJECTIVES: To define the clinical spectrum time-course and prognosis of non-Asian patients positive for anti-MDA5 antibodies.METHODS: We conducted a multicentre, international, retrospective cohort study.RESULTS: 149 anti-MDA5 positive patients (median onset age 53 years, median disease duration 18 months), mainly females (100, 67%), were included. Dermatomyositis (64, 43%) and amyopathic dermato
AIMS: According to the 2019 European Society of Cardiology (ESC) guidelines on chronic coronary syndromes (CCS), adding a P2Y12 inhibitor or rivaroxaban to aspirin should be considered in high-risk patients. We estimated the proportion of patients eligible for treatment with the ESC criteria and examined if a recently validated risk score (CHADS-P2A2RC) could improve risk prediction. METHODS AND R
The purpose of this systematic review and meta-analysis is to determine the effect of lockdowns on COVID-19 mortality based on available empirical evidence. Lockdowns are defined as the imposition of at least one compulsory, non-pharmaceutical intervention (NPI). We employ a systematic search and screening procedure in which 19,646 studies are identified that could potentially address the purpose
Rising demand for food production poses a major threat to biodiversity by placing competing pressures on land. Diversified farming systems are one widely promoted nature-based solution to this challenge, which aim to integrate biodiversity-based ecosystem services into agricultural production. The underlying theory behind this approach is that diverse communities enhance ecosystem service provisio
During the last decade it has been increasingly acknowledged that carbon (C) contained in root exudates can accelerate decomposition of soil organic matter (SOM), a phenomenon known as rhizosphere priming effect (RPE). However, the controlling factors and the role of different soil microorganisms in RPE are not yet well understood. There are some indications that the response of the soil microbial
Cell culturing methods are increasingly used to reduce and replace the use of live animals in biomedical research and chemical toxicity testing. Although live animals are avoided when using cell culturing methods, they often contain animal-derived components of which one of the most commonly used is foetal bovine serum (FBS). FBS is added to cell culture media among other supplements to support ce
Background: Several studies described the cross-sectional characteristics of systemic sclerosis patients and coexisting primary biliary cholangitis, but longitudinal prognostic data are lacking. Aims: To describe the systemic sclerosis–primary biliary cholangitis phenotype, including baseline characteristics and outcomes. Methods: We performed a multicentre the European Scleroderma Trials and Rese
Background: Since the first version of the dietary inflammatory index (DII®) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation. Objective: We aimed to investigate the relationship between four dietary inflammatory scores [DII, two energy-adjus
The vast majority of students at universities in Sweden are members of student unions. Universities strongly encourage students to enter unions as they give access to discounts, social events, clubs, and internships. Student unions are tasked with representing students towards the university. In addition, union membership in Sweden is rarely believed to have a political connotation. While often be
Dynamic Global Vegetation Models (DGVMs) provide a state-of-the-art process-based approach to study the complex interplay between vegetation and its physical environment. For example, they help to predict how terrestrial plants interact with climate, soils, disturbance and competition for resources. We argue that there is untapped potential for the use of DGVMs in ecological and ecophysiological r
Carbon dioxide (CO2) uptake by plant photosynthesis, referred to as gross primary production (GPP) at the ecosystem level, is sensitive to environmental factors, including pollutant exposure, pollutant uptake, and changes in the scattering of solar shortwave irradiance (SWin) − the energy source for photosynthesis. The 2020 spring lockdown due to COVID-19 resulted in improved air quality and atmos
PurposeThis study aimed to characterize the Swedish cohort of surgically treated patients with TSC and explore differences in preoperative investigation and outcome over time.MethodsData on patient and seizure characteristics were retrieved from the Swedish National Epilepsy Surgery Register. Two-year follow-up results were compared between the years 1997–2010 and 2011–2018. Preoperative investiga
Popular Abstract in Swedish Vi lever i en tid och i ett samhälle där kemikalier har blivit en naturlig del av vår industrialiserade vardag. Till stor del ligger kemikalieindustrin bakom flera av de stora tekniska framsteg som gör att västvärlden har den levnadsstandard den idag har. Tyvärr har den stora spridningen av icke naturligt förekommande kemikalier ibland också negativa effekter både på miThe modern world is increasingly dependent of the use of chemicals. The chemical industries have greatly contributed to the high standard of living in industrialised societies, and chemical compounds surround us in everyday life. Unfortunately, a vast number of chemicals cause adverse effects on the environment and human health. One such concern is chemical hypersensitivity, which is a state cause
Popular Abstract in Swedish Den rykande startpistolen eller Konsten att ta tid på en flygande elektron Flygande elektroner kan berätta mycket om hur världen sitter ihop. Elektroner som lämnar ytan av något material avslöjar både vilka atomer som finns i materialet och hur de kemiska bindingarna ser ut. Allt detta är nödvändigt att förstå när man vill utveckla nya material – till exempel för kretTime-of-flight (TOF) techniques for energy analysis have been common in electron spectroscopy for many decades. TOF-based electron spectrometers benefit from higher transmission and information rate compared to their main competitor: the hemispherical analyser; the drawback being their lower energy resolution. However, the advent of angle-resolved TOF spectrometers for electron energy analysis cha
Objective: To evaluate long-term oncological outcome and surgical quality of robotic radical hysterectomy for cervical cancer. Methods: Consecutive women with stage IA2 to IIA operated between March 2006 and May 2012 with a robotic radical hysterectomy and pelvic lymphadenectomy were prospectively followed up until five years after surgery or until death. Details regarding clinical results, recurr
Gene therapy for inherited retinal diseases has been shown to ameliorate functional and structural defects in both animal models and in human clinical trials. X-linked retinoschisis (XLRS) is an early-age onset macular dystrophy resulting from loss of an extracellular matrix protein (RS1). In preparation for a human clinical gene therapy trial, we conducted a dose-range efficacy study of the clini
BACKGROUND: Physciosporin (PHY) is one of the potent anticancer lichen compound. Recently, PHY was shown to suppress colorectal cancer cell proliferation, motility, and tumorigenesis through novel mechanisms of action.PURPOSE: We investigated the effects of PHY on energy metabolism and tumorigenicity of the human breast cancer (BC) cells MCF-7 (estrogen and progesterone positive BC) and MDA-MB-231
