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Bone morphogenetic proteins (BMP) are powerful regulators of cellular processes such as proliferation, differentiation, and apoptosis. However, the specific molecular requirements controlling the bioavailability of BMPs in the extracellular matrix (ECM) are not yet fully understood. Our previous work showed that BMPs are targeted to the ECM as growth factor-prodomain (GF-PD) complexes (CPLXs) via
Corporate net-zero emission pledges have multiplied in recent years, with estimates suggesting that more than 1000 companies have made such commitments. While seemingly indicative of companies stepping up to address climate change, critics have argued that pledges may be mere greenwashing if they rely on excessive offsetting and legitimise business-as-usual. Considerable grey and academic literatu
The lifetime of an enzyme is critical to prevent system failure and optimize maintenance schedules in biological and analytical chemistry. The lifetime metrics of an enzyme can be evaluated from enzyme activity in terms of catalytic cycles per enzyme at various storage times. Trypsin, which is a gold-standard enzyme in proteomics, has been known to decrease activity due to self-digestion. To impro
Nonintrusive temperature measurement is crucial in combustion research. Here, we propose a thermometric technique based on femtosecond two-photon laser-induced fluorescence of carbon monoxide (CO-fs-TPLIF). A femtosecond laser with a wavelength of 230 nm was used as an excitation source. Owing to its intrinsic broad bandwidth, dual vibrational bands of the B1Σ+ ← X1Σ+ transition of CO can be simul
Scattering amplitudes are often split up into their color (su(N) ) and kinematic components. Since the su(N) gauge part can be described using flows of color, one may anticipate that the su(2 ) ⊕ su(2 ) kinematic part can be described in terms of flows of chirality. In two recent papers we showed that this is indeed the case, introducing the chirality-flow formalism for standard model calculations
We use the superfluid tunneling model (STM) to calculate the half-lives of α decays of odd-A and odd-odd superheavy nuclei (SHN) with Z≥100 and A≥250. The experimental data are reproduced to accuracies comparable to other contemporary models of the α decay of the SHN. We then apply the STM to examine the influence of the quasiparticle structure on the properties of the chains of α decays arising f
Urgent water and food security challenges, particularly in continental and boreal regions, need to be addressed by initiatives such as the Horizon 2020‐funded project WATer retention and nutrient recycling in soils and streams for improved AGRIcultural production (WATERAGRI). A new methodological framework for the sustainable management of various solutions resilient to climate change has been dev
In this letter, we give an upper bound on the deviation from H-infinity optimality of a class of controllers as a function of the deviation from symmetry in the state matrix. We further suggest a scalar measure of symmetry which is shown to be directly relevant for estimating nearness to optimality. In connection to this, we give a simple analytical solution to a class of Lyapunov equations for tw
The Forward Physics Facility (FPF) is a proposal to create a cavern with the space and infrastructure to support a suite of far-forward experiments at the Large Hadron Collider during the High Luminosity era. Located along the beam collision axis and shielded from the interaction point by at least 100 m of concrete and rock, the FPF will house experiments that will detect particles outside the acc
Abstract α-Synuclein is a small neuronal protein that reversibly associates with lipid membranes. The membrane interactions are believed to be central to the healthy function of this protein involved in synaptic plasticity and neurotransmitter release. α-Synuclein has been speculated to induce vesicle fusion as well as fission, processes which are analogous to each other but proceed in different d
Jet impingement cooling was investigated on a flat heating surface placed in a flow channel, including single jet cooling, in-line double jet cooling, and combined crossflow and jet cooling; cross-flow cooling was a baseline for comparison. In addition, the in-line double jet cooling was explored with various jet distances. Local Nusselt number distribution was experimentally achieved by the liqui
Introduction: Research and healthcare services struggle to fulfil the desires and needs of nursing home residents, and there is a call for person-centredness in both research and healthcare practice. Involvement of people outside academia in research has been advocated in an effort to increase the relevance and impact of research findings for the public. However, little is known on how to involve
Heat exchanger network synthesis is an essential optimisation tool for Process Integration, particularly in energy-intensive industries. Proper design or retrofit of heat exchanger network can enable energy conservation, efficiency improvement, and process debottlenecking. Many earlier pieces of research have focused on the impact of the network structure and process features such as network topol
Visual opsins of vertebrates and invertebrates diversified independently and converged to detect ultraviolet to long wavelengths (LW) of green or red light. In both groups, colour vision largely derives from opsin number, expression patterns and changes in amino acids interacting with the chromophore. Functional insights regarding invertebrate opsin evolution have lagged behind those for vertebrat
The visual environment provides vital cues allowing animals to assess habitat quality, weather conditions or measure time of day. Together with other sensory cues and physiological conditions, the visual environment sets behavioral states that make the animal more prone to engage in some behaviors, and less in others. This master-control of behavior serves a fundamental and essential role in deter
Nanofiber-reinforced hydrogels have recently gained attention in biomedical engineering. Such three-dimensional scaffolds show the mechanical strength and toughness of fibers while benefiting from the cooling and absorbing properties of hydrogels as well as a large pore size, potentially aiding cell migration. While many of such systems are prepared by complicated processes where fibers are produc
The influence of the choice of process parameters in an industrial high-power impulse magnetron sputtering (HiPIMS) system on the surface roughness and crystallinity of Ti coatings is presented in this work. A current density of 1 A/cm2 was kept constant by varying the pulse frequency to control the average power. The films were characterised by scanning electron microscopy, atomic force microscop
