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I mitt forskningsprojekt har jag studerat generna i ’the major histocompatibility complex’ (MHC). Generna i detta komplex kodar för molekyler som uttrycks på cellytan och dessa molekyler är avgörande för immunförsvarets förmåga att upptäcka och bekämpa patogener (sjukdomsalstrande mikroorganismer, som virus, bakterier och parasiter). Det övergripande syftet i min forskning har varit att undersöka Sex differences in immune responses have been observed across a wide range of animal species, with the generaltendency that males have weaker immune responses than females. These differences are at least partly caused by immune-regulating effects of sex hormones, and have been associated with an increased prevalence of autoimmune disorders in females and with a general tendency for males to be par

Radiation feedback is typically implemented using subgrid recipes in hydrodynamical simulations of galaxies. Very little work has so far been performed using radiation-hydrodynamics (RHD), and there is no consensus on the importance of radiation feedback in galaxy evolution. We present RHD simulations of isolated galaxy discs of different masses with a resolution of 18 pc. Besides accounting for s

Objective: To assess function using the Signals of Functional Impairment (SOFI) instrument over 8 years, to study clinical variables associated with the change, and to study change over time of the SOFI items. Methods: In total, 1,223 patients with early rheumatoid arthritis (RA) from the Better Anti-Rheumatic Farmacotherapy (BARFOT) cohort (mean ± SD age 56.9 ± 15.4 years, 67% women) were include

We analyze the sensitivity of hadronic τ decays to nonstandard interactions within the model-independent framework of the standard model effective field theory. Both exclusive and inclusive decays are studied, using the latest lattice data and QCD dispersion relations. We show that there are enough theoretically clean channels to disentangle all the effective couplings contributing to these decays

(E)valuative technologies such as standards and conventionalized (e)valuative practices, some including the use of technological devices, govern the production of food in the global north. Food supply chains consist of multiple interrelated markets, where goods are (e)valuated to distinguish their qualities and prices. Qualities and prices that are transformed as the raw materials move through the

We performed spatially resolved near-ambient-pressure photoemission spectromicroscopy on graphene-coated copper in operando under oxidation conditions in an oxygen atmosphere (0.1 mbar). We investigated regions with bare copper and areas covered with mono- and bi-layer graphene flakes, in isobaric and isothermal experiments. The key method in this work is the combination of spatial and chemical re

The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for modern-day populations, which are known to misrepresent the population structure. P

Gas-liquid mass transfer in wastewater treatment processes has received considerable attention over the last decades from both academia and industry. Indeed, improvements in modelling gas-liquid mass transfer can bring huge benefits in terms of reaction rates, plant energy expenditure, acid-base equilibria and greenhouse gas emissions. Despite these efforts, there is still no universally valid cor

The effect of insulin secretagogues on the incorporation of [32P]ortho-phosphate into phospholipids was studied in microdissected islets from obese-hyperglycemic mice. Increased 32P-labelling was observed after incubation for 60 min with 10 mM l-leucine, 10 mM l-arginine or 20 mM d-glucose. Most of the label occurred in the phosphatidyl inositol fraction. The effect of l-leucine was additive to th

Commodity prices and their secular trends are at the core of many different development theories, particularly relevant for the Latin American region, like the Prebisch-Singer hypothesis, the natural resource curse theory or the somehow malthusian scarcity prediction. In this article we review the international copper price indices available in the literature and we compare them with a new data se

Purpose: This paper sets out to examine how CEOs’ talk of sustainability has developed in a period of increased expectations from society for companies to step up their transformation towards more sustainable businesses andbetter account for their progress and performance within the sustainability area.Design/methodology/approach: By adopting an interpretive textual approach, this paper pr

Background: Cerebrospinal fluid (CSF) biomarkers have gained increasing importance in the diagnostic work-up of Alzheimer's disease (AD). The core CSF biomarkers related to AD pathology (Aβ42, t-tau and p-tau) are currently used in CSF diagnostics, while candidate markers of amyloid metabolism (Aβ38, Aβ40, sAPPα, sAPPβ), synaptic loss (neurogranin), neuroinflammation (YKL-40), neuronal damage (VIL

Legislation for dementia care needs to be continually rethought, if the rights of older persons and other persons with dementia are to be addressed properly. We propose a theoretical framework for understanding vulnerability and dependency, which enables us to problematize the currently prevailing legal conception of adults as always able-irrespective of health or age-to act autonomously in their

Running-in process of low metallic brake pads and cast iron discs are investigated using full scale inertia brake dynamometer designed for particle emission studies. The airborne particles are measured using ELPI+ and collected on filters. The pads and disc contact surfaces are studied using microscopy techniques. It is observed that the particle emissions from the new pads and discs are significa

One way to analyze the twists and turns in Swedish history politics regarding the Second World War and its legacy is to turn to a typol-ogy of uses of history. Despite differences in occupations, places, and times, uses of history are often joined together by certainneeds and functions that certain choices of history can provide. In this pa-per, I discuss how the images of the Second Worl

Species of Horismenus Walker associated with bruchid beetles are investigated and five new species are described. Some of the new species are very similar to already described species and have previously been misidentified. The new species include H. depressoides sp. nov. similar to H. depressus Gahan, H. stator sp. nov. similar to H. missouriensis (Ashmead), and H. dennoi & H. multistriatus s

Direct numerical simulations (DNS) of low and high Karlovitz number (Ka) flames are analysed to investigate the behaviour of the reactive scalar sub-grid scale (SGS) variance in premixed combustion under a wide range of combustion conditions (regimes). An order of magnitude analysis is performed to assess the importance of various terms in the variance evolution equation and the analysis is valida

A method to estimate the nonideal features of the transfer function of individual differential mobility analyzers (DMA) was developed and tested experimentally. This was up to now an unsolved problem, which is important for the precision in DMA measurements. The method involves three DMAs of unknown characteristics, which are used in three rounds of experiments with two DMAs according to a fixed s