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Living as a person using a lower-limb prosthesis in Nepal

Purpose: The purpose of this study is to explore experiences of persons in Nepal using lower-limb prostheses, in relation to specific articles in the Convention on the Rights of Persons with Disabilities that consider mobility, education, health, rehabilitation, and work and employment. Method: Qualitative interviews were conducted with 16 persons using lower limb prostheses. Content analysis was

Which advanced heart failure therapy strategy is optimal for patients over 60 years old?

BACKGROUND: The optimal advanced heart failure (HF) therapy strategy for patients aged 60 or older with end-stage HF refractory to optimal medical therapy remains uncertain. This study compares outcomes of three advanced HF therapy strategies in this patient population. METHODS: A single-center retrospective study was conducted in 95 patients aged 60-73 years who had undergone isolated heart trans

Human IgM monoclonal antibodies block HIV-transmission to immune cells in cervico-vaginal tissues and across polarized epithelial cells in vitro

The importance of natural IgM antibodies in protection against infections is still emerging and these antibodies have a potential role in the maintenance of homeostasis through clearance of apoptotic bodies, complement-dependent mechanisms, inflammation and exclusion of misfolded proteins. Natural IgM act as a first line of defence against unknown hazardous factors and are present in most vertebra

The stellar mass-halo mass relation of isolated field dwarfs : A critical test of ΛCDM at the edge of galaxy formation

We fit the rotation curves of isolated dwarf galaxies to directly measure the stellar mass-halo mass relation (M*-M200) over the mass range 5 × 105 ≲ M*/M⊙ ≲ 108. By accounting for cusp-core transformations due to stellar feedback, we find a monotonic relation with little scatter. Such monotonicity implies that abundance matching should yield a similar M*- M200 if the cosmological model is correct

UV and IR Absorption Cross-sections of HCHO, HCDO, and DCDO

UV (240-370 nm) and IR (3200-1500 cm-1) absorption cross-sections of HCHO, HCDO, and DCDO in abath gas of N2 at atmospheric pressure and 296 K are reported from simultaneous measurements in the twospectral regions. Cross-sections were placed on an absolute scale through quantitative conversion offormaldehyde to CO and HCOOH by titration with Br atoms, also monitored by FTIR. The integrated UVabsor

On the coherence properties of FEL

FELs are well known for generating highly coherent light with excellent brilliance. In order to improve FEL coherence we have to follow how coherence evolves along the undulator and determine the factors that influence it the most. This paper presents qualitative coherence features that shine new light on the importance of coherence studies in the design of an FEL. By simulating and then analyzing

Chemical composition and in vitro starch digestibility of pigmented corn tortilla

BACKGROUND: Tortillas were prepared from two (blue and regular white) maize varieties and compared with regard to chemical composition and in vitro starch digestibility, i.e., available starch (AS), total (RS) and retrograde (RRS) resistant starch contents, amylolysis rate and predicted glycemic index (pGI). The impact of cold storage (4°C) on digestibility was also investigated. RESULTS: Despite

Subtilisin inhibitors in Canavalia and Vicia faba seeds. A comparative study

Subtilisin isoinhibitors (SI) were isolated from jack bean (Canavalia ensiformis L) and broad bean (Vicia faba L) seeds. Jack beans contain three isoinhibitors (pI 6.6, 6.3 and 6.0) that constitute 0.021 g per 100 g of dry seeds, while the two active proteins from broad beans (pI 5.7 and 5.1) represent 0.028%. The molecular weight, determined by gel filtration, is around 8000 D in both legumes. La

Linking lean to green – energy efficiency as a value stream

Over the past few decades, lean management philosophies have penetrated various sectors of industry. At same time, dynamic environmental, or green, management is needed to succeed in the current green conscious market. Some research has already been conducted on the potential synergy gains of the two management philosophies, since both are known to strive towards efficient use of resources, elimin

Galectin-8 in IgA Nephritis: Decreased Binding of IgA by Galectin-8 Affinity Chromatography and Associated Increased Binding in Non-IgA Serum Glycoproteins.

BACKGROUND: Immunoglobulin A nephritis (IgAN) is the most common primary glomerulonephritis worldwide. It is caused by accumulation of IgA1-containing immune complexes in the kidney resulting in renal failure, which is thought to be due to altered glycosylation of IgA with a decrease of 2-3-sialylated galactosides (NeuAcα2-3Gal). PURPOSE: The purpose of this study was to analyze whether altered gl

Decreasing Blood Pressure Over Time is the Strongest Predictor of Depressive Symptoms in Octogenarian Men.

OBJECTIVE: The aim of this study was to examine the longitudinal impact of blood pressure variations and vascular risk factors on depressive symptoms in the elderly. DESIGN: Longitudinal and cross-sectional cohort study. SETTING: Urban population of elderly men, city of Malmö, Sweden. PARTICIPANTS: A total of 809 randomly included men took part in a prospective cohort study, "Men born in 1914", an

Radiative lifetime measurements and transition probabilities of astrophysical interest in ErIII

Radiative lifetimes of seven excited states of Er iii have been measured using time-resolved laser-induced fluorescence following two-photon excitation. Relativistic Hartree-Fock calculations taking core-polarization effects into account are found to be in excellent agreement with the experimental results. A large set of new calculated transition probabilities is presented for many transitions of

A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion.

The influential role of Wnt5a in tumor progression underscores the requirement for developing molecules that can target Wnt5a-mediated cellular responses. In the aggressive skin cancer, melanoma, elevated Wnt5a expression promotes cell motility and drives metastasis. Two approaches can be used to counteract these effects: inhibition of Wnt5a expression or direct blockade of Wnt5a signaling. We hav

Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society.

Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays are being developed for these purposes, it is important to optimize and standardi

Do some languages sound more beautiful than others?

Italian is sexy, German is rough—but how about Páez or Tamil? Are there universal phonesthetic judgments based purely on the sound of a language, or are preferences attributable to language-external factors such as familiarity and cultural stereotypes? We collected 2,125 recordings of 228 languages from 43 language families, including 5 to 11 speakers of each language to control for personal vocal

Preventing falls with the LIVE-LIFE program: Pilot outcomes of a multicomponent OT-led intervention addressing health-related and home-related fall risks in community-living older adults

Introduction: There are multiple contributors to falls in older adults. Both health-related (poor balance, polypharmacy, and poor vision), and home-related (home hazards). However, most fall risk interventions only address one or two. The successful Lifestyle Intervention Functional Exercise (LiFE) program could likely be developed into a multicomponent intervention. Objectives: The objectives wer

The Villa - A sacred space?

A fundamental difference between ordinary and leisure time is for many the ability to indulge in extra-ordinary activities of both body and mind. Rooted in antiquity, the renaissance villas were often used as spaces for indulgence of artistic endeavors, be it philosophical discussions, poetry-writing or lavish parties. Of indulgence, Aristoteles wrote: ‘The self-indulgent man craves for all pleasa