Filtyp
A comparison between second language learners of Swedish, some of whom have an L1 with lexical tones, while the others do not, and their ability to produce adequate tonal word accents in Swedish is presented. The L1s in question are Farsi, Somali, Vietnamese and Thai. There is no clear evidence that it is easier to learn the correct Swedish word accent patterns and their correct application for sp
Popular Abstract in Swedish Immunsystemet skyddar oss mot de patogener (t ex bakterier eller virus) som vi dagligen utsätts för. Det består av flera olika samtidigt verkande system. De enklare består av vår hud och de olika slemhinnor som finns till exempel i halsen och i tarmsystemet. Vidare finns det olika typer av celler och blodproteiner som kan skydda oss mot många infektioner. Det mest utvecThis thesis focuses on molecular changes occuring during terminal B cell differentiation as well as on somatic hypermutation and the generation and maintenance of B cell memory. During T cell dependent immune responses the average affinity for the eliciting antigen increases with time. This affinity maturation is generated by somatic hypermutation and selection for B cells carrying a high-affinty
The reassignment technique is used to increase the localization for signals that have closely located time-frequency components. For Gaussian components the reassignment based on an optimal (matched) window spectrogram will result in a single point where all mass is located. For non-optimal windows, the reassignment procedure can be optimally rescaled to fulfill the single point mass location. Non
The humoral immune response to a T cell dependent protein antigen will over time generate antibodies with an increased affinity to the antigen. This is due to a process known as affinity maturation and proceeds in a, for this purpose, well designed micro-milieu within secondary lymphoid organs known as germinal centres. The increase in affinity of an antibody in, e.g. mouse and man is due mainly t
AIMS: The sural nerve is the commonest peripheral nerve biopsied to help in the diagnosis of peripheral neuropathy of unknown cause. However, associated complications limit its use. The aim was, as an alternative, to asses biopsy of the terminal branch of the posterior interosseous nerve (PIN) in the forearm. METHODS: PIN pathology was morphometrically quantified in 10 male patients with Type 2 di
Artikeln diskuterar en väsentligen nordamerikansk tanketradition som explicit eller implicit framställer den centrala antika filosofiska frågan – ”hur bör jag leva?” – som sin frågehorisont, och som gör det såväl teoretiskt, empiriskt som normativt. Det handlar om sociologer och andra samhällsvetare, men också om litteraturvetare och kulturkritiker, essäister och skönlitterära författare. ArtikelnThe article describes and analyses an essentially American intellectual tradition which explicitly or implicitly poses the central question of Hellenistic and Roman philosophy – ”how should I live?” – as its main theme and concern, and which discusses the matter theoretically, empirically, and normatively. The tradition includes sociologists and other social scientists, but also cultural theorists
beta 2-microglobulin (beta 2m) was found to interact with many group A streptococcal strains. The interaction appeared to require multipoint attachment, since monomeric beta 2m in solution showed no binding, whereas both beta 2m monomers bound to liposomes, and beta 2m in aggregates showed affinity for the bacteria. Aggregated HLA antigens (-A, -B and -C) and aggregated beta 2m exhibited the same
The formation of complexes in solutions of oppositely charged polyions has been studied by Monte Carlo simulations. The amount as well as the length, and thus, the absolute charge of one of the polyions have been varied. There is an increasing tendency to form large clusters as the excess of one kind of polyion decreases. When all polyions have the same length, this tendency reaches a maximum near
The nonobese diabetic mouse is highly susceptible not only to diabetes but to several autoimmune diseases, and one might suspect that these are controlled by a shared set of genes. However, based on various gene-segregation experiments, it seems that only a few loci are shared and that each disorder is influenced also by a unique set of genes.
Escherichia coli TolA is a cytoplasmic membrane protein required for outer membrane integrity and the translocation of F-specific filamentous (Ff) bacteriophage DNA. Both phage infection and membrane integrity depend on several TolA interactions, e.g. those of the TolA C-terminal domain (TolAIII). Membrane integrity involves interaction with two host proteins and phage translocation requires direc
