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Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recom
Enzymes that affect glycoproteins of the human immune system, and thereby modulate defense responses, are abundant among bacterial pathogens. Two endoglycosidases from the human pathogen Streptococcus pyogenes, EndoS and EndoS2, have recently been shown to hydrolyze N-linked glycans of human IgG. However, detailed characterization and comparison of the hydrolyzing activities have not been performe
De novo differentiation of CD4(+) Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo following the transfer of naive CD4(+) CD45RB(high) T cells to strains of RAG2-defici
The skin is a barrier membrane that separates environments with profoundly different water contents. The barrier properties are assured by the outer layer of the skin, the stratum corneum (SC), which controls the transepidermal water loss. The SC acts as a responding membrane, since its hydration and permeability vary with the boundary condition, which is the activity of water at the outer surface
We propose an event-based account of the cognitive and linguistic representation of time and temporal relations. Human beings differ from nonhuman animals in entertaining and communicating elaborate detached (as opposed to cued) event representations and temporal relational schemas. We distinguish deictically based (D-time) from sequentially based (S-time) representations, identifying these with t
Objective: To describe and compare speech and phonology at age 3 years in children born with unilateral complete cleft lip and palate treated with three different methods for primary palatal surgery. Design: Prospective study. Setting: Primary care university hospitals. Participants: Twenty-eight Swedish-speaking children born with nonsyndromic unilateral complete cleft lip and palate. Interventio
The performance of new firms is important for economic development but research has produced limited knowledge about the key relationships among growth, profitability, and survival for new firms. Based on evolutionary theory, we develop a model about how new firms resolve uncertainty about their ability to prosper in a market by monitoring changes in profitability. Our model predicts selection pre
This study investigates the relationship between prosody and information/discourse structure in spon- taneous spoken folk tales in the tonal Mon-Khmer language Northern Kammu, a language that behaves as a typical phrase language where available boun- dary tones are enhanced to mark information struc- turing. Topic is always placed before Comment by syntactic movement if necessary. There is a proso
Exoplanet interior modelling usually makes the assumption that the elemental abundances of a planet are identical to those of its host star. Host stellar abundances are good proxies of planetary abundances, but only for refractory elements. This is particularly true for terrestrial planets, as evidenced by the relative differences in bulk chemical composition between the Sun and the Earth and othe
The introduction of total prostate-specific antigen (tPSA) testing in serum has revolutionized the detection and management of men with prostate cancer. This review will highlight some of the exciting new developments in the field of prostate cancer screening in general and from our SPORE research program at Memorial-Sloan Kettering Cancer Center. First, it is important to understand that the inhe
This chapter focuses on the relation between mass consumption and political consumerism. Mass consumption concerns the omnipresent role of consumption in contemporary societies with associated problems of excessive resource use in current practices of consumption. The late modern context and forces of mass consumption can both trigger and prevent political consumerism as well as shape its outcome.
