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Building a map of the breast cancer proteome - Strategies to increase coverage

Popular Abstract in Swedish Uppsättningen av gener i DNA, genomet, kan betraktas som drivande för konstruktionen av varje levande varelse, medan motsvarande proteiner, proteomet, är materiellt ansvariga för de flesta biologiska processer. Kort sagt, gener bestämmer vad celler ”ska kunna göra” medan proteiner definierar vad varje cell "gör" ur en funktionell synvinkel. Aktiviteten hos dessa molekylAmongst the various –omics sciences, proteomics has the highest potential for functional characterization and consequently can contribute significantly to the field of cancer research. In particular, the focus of this thesis is on breast cancer. Alas, since state-of-the-art technologies cannot meet the complexity of upper eukaryotic proteomes, a complete resolution of clinical samples is still una

SOFC modeling at the cell scale including hydrogen and carbon monoxide as electrochemically active fuels

Fuel cells are promising for future energy systems, because they are energy efficient and able to use renewable fuels. A fully coupled computational fluid dynamics (CFD) approach based on the finite element method (with the software COMSOL Multiphysics) in two-dimensions is developed to describe an intermediate temperature solid oxide fuel cell (SOFC) single cell. Governing equations covering heat

Implicit acquisition of tone-suffix connections in L2 learners of Swedish

Swedish native speakers (NSs) unconsciously use tones realized on word stems to predict upcoming suffixes during speech comprehension. The present response time study investigated whether relatively proficient second language (L2) learners of Swedish have acquired the underlying association between tones and suffixes without explicit instruction, internalizing a feature that is specific to their L

Producing anxiety in the neoliberal university

This paper presents a theoretical analysis of the neoliberal production of anxiety in academic faculty members in universities in Northern Europe. The paper focuses on neoliberalization as it is instantiated through audit and ranking systems designed to produce academia as a space of economic efficiency and intensifying competition. We suggest that powerful forms of competition and ranking of acad

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Abstract in Arabic مع بداية النصف الثاني من القرن الماضي أو تحديدا نهاية العقد الخامس وبداية العقد السادس، انطلقت بدايات الكتابة النسائية الإبداعية في عدد من الدول العربية حتى فرضت الكاتبات العربيات وجودهن بقوة في المشهد الثقافي الإبداعي وتألقن في تقديم التجربة النسوية لاحقا، ليجسدن لنا واقع المرأة ويعبرن عن خصوصيتها الأنثوية وأحاسيسها وتجربتها الاجتماعية آأنثى، فأسمعتنا صوتها عبر شخصيتها المحورية

Religion in post-disaster recovery

Religion is particularly important in times of crises; it is commonly linked to the search for meaning behind disasters and it promotes a social interconnectedness. After a disaster, religious beliefs can give the survivors a sense of control. Rituals and ceremonies have proved to have healing capacities both individually and collectively. The focus of this paper is on religion in the recovery pro

Prosodic signaling of information and discourse structure from a typological perspective

This study investigates the relationship between prosody and information/discourse structure in spon- taneous spoken folk tales in the tonal Mon-Khmer language Northern Kammu, a language that behaves as a typical phrase language where available boun- dary tones are enhanced to mark information struc- turing. Topic is always placed before Comment by syntactic movement if necessary. There is a proso

Legal and Social Norms for Development:Why legal reform of the informal economy failed to influence vulnerable groups in developing countries

Using the concepts of social norms and social reality, this chapter explores why legal reforms that aimed to facilitate the formalization of informal workers have largely failed to influence vulnerable groups in developing countries. It explores the use of legal reforms in order to achieve development and poverty reduction. Using empirical material from a qualitative study conducted in Colombia am

Covariance Analysis, Positivity and the Yakubovich-Kalman-Popov Lemma

This paper presents theory and algorithms for covariance analysis and stochastic realization without any minimality condition imposed. Also without any minimality conditions, we show that several properties of covariance factorization and positive realness hold. The results are significant for validation in system identification of state-space models from finite input-output sequences. Using the R

A Novel Approach to Predict the Likelihood of Specific Ovarian Tumor Pathology Based on Serum CA-125: A Multicenter Observational Study.

BACKGROUND: The CA-125 tumor marker has limitations when used to distinguish between benign and malignant ovarian masses. We therefore establish likelihood curves of six subgroups of ovarian pathology based on CA-125 and menopausal status.METHODS: This cross-sectional study conducted by the International Ovarian Tumor Analysis group involved 3,511 patients presenting with a persistent adnexal mass

Application of frequency and sample entropy to discriminate long-term recordings of paroxysmal and persistent atrial fibrillation

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. At an early stage of the disease, AF may terminate spontaneously and is then referred to as paroxysmal AF. On the other hand, when external intervention is required for the arrhythmia to terminate, it is referred to as persistent AF. In this work, a method to discriminate between paroxysmal and persistent AF in the long-t

Words that go together well: developing test formats for measuring learner knowledge of English collocations

This paper describes the development of two test formats, COLLEX and COLLMATCH, measuring receptive recognition knowledge of English verb +NP collocations, and reports findings from pilots and initial test administrations involving Swedish upper-secondaryschool and university level learners. Administrations of the test formats produced highly reliable scores and the performance of native speakers

A 12-bit 125-MHz segmented current-steering DAC for communication application

A 12-bit 125-MHz digital-to-analog converter (DAC) for communication application is designed. It is based on current-steering segmented architecture and modified Q2 random walk switching scheme to obtain 12-bit accuracy. A new voltage swing reduced driver (VSRD) is implemented to promote the dynamic performance. The DAC uses 0.18 µm 1.8 V standard digital CMOS technology. The die area (core) is 2.

Complement inhibitor C4b-binding protein in primary Sjögren's syndrome and its association with other disease markers.

A subgroup of patients suffering from primary Sjögren's syndrome (pSS) display unexplained low levels of complement components C3 and/or C4 which is associated with increased risk of non-Hodgkin's lymphoma. C4b-binding protein (C4BP) is a major fluid-phase complement inhibitor which can influence C4 and C3 levels. Therefore we analysed C4BP levels in the sera of patients with pSS to better underst