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Proteome analysis of cultured fibroblasts from type 1 diabetic patients and normal subjects

Context: Protein profiling of diabetic tissues could provide useful biomarkers for early diagnosis, therapeutic targets, and disease response markers. Cultured fibroblasts are a useful in vitro model for proteome analysis and study of the molecular mechanisms involved in diabetes. Objective: The objective of the study was to isolate and characterize the proteins of cultured fibroblasts, obtained b

Exploring central and peripheral diversity in antibody evolution.

The antigen-binding site, the paratope, of an antibody can be seen as being composed of a central core and a more peripheral area situated at its rim. Naturally these regions acquire their diversity using different mechanisms and they also have dissimilar roles, as they contribute differently to the binding interaction. Also, antigens of different size utilize these regions differently; while hapt

Performance trade-offs in designing a dual-band CMOS IEEE 802.11A/B frontend

This paper describes trade-offs involved in designing a dual-band CMOS frontend for wireless local-area network (WLAN). Three 0.18μm CMOS frontends have been investigated, a single-band frontend at the 2.4 GHz ISM band, a single-band frontend at the 5 GHz U-NII band and a dual-band frontend. The study shows that employing a dual-band frontend yields satisfactory results, although some compromises

Skolledare i grundskolan : en fallstudie av biträdande rektorers möte med skolledning

Popular Abstract in Swedish Den svenska grundskolan har under de senaste åren genomgått och genomgår fortfarande en stark utveckling inom ramen för den allmänna decentraliseringen i samhället. Beslut och ansvar läggs allt längre ner i organisationen. De krav som ställdes på en skolledare tillbaka i tiden var i första hand att han skulle vara administratör och den som bevakade att skolans verk-samThe issues of the study are: How do the assistant principals face the work as school leaders? Which demands of competence do the new school leaders face? Which needs of competence development exist for new school leaders? In the school studied the organization of the management was changed from one principal and one director of studies to one principal and six assistant principals. All of these we

MAX 4, A 3 GEV light source

A proposal for a new synchrotron light source, MAX 4, is presented. The main components are two identical storage rings operated at different electron beam energies and equipped with superconducting insertion devices. Small beam emittances will yield high brilliance radiation over a wide spectral range. A small horizontal emittance is achieved by using a large number of cells with gradient dipoles