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Background and purpose — Backside wear of the polyethylene insert in total knee arthroplasty (TKA) can produce clinically significant levels of polyethylene debris, which can lead to loosening of the tibial component. Loosening due to polyethylene debris could theoretically be reduced in tibial components of monoblock polyethylene design, as there is no backside wear. We investigated the effect of

In this work, 22 sets of cutting data and tool life for longitudinal turning of steel are analyzed using the Colding equation. When modeling tool life with a limited number of tool performance data points, the model error may be low for these points. Evaluating the model for test points not used when computing the model coefficients may give larger errors for these points. This work proves that th

This paper describes an ascending evacuation model based on physical work capacity, when exhaustion may play a key role during evacuation. The experiment was carried out on a stair machine (StairMaster, SM5, USA) which involved 13 male and 12 female subjects. Individual climbing speeds at 50 and 70 % of their maximal aerobic capacity (% VO2max) level (L1 and L2) were selected for 3 minutes, and 90

This study attempts to apply computational methods to the Twitter Election Integrity Datasets in order to derive a basic descriptive overview of this disinformation data, and to suggest some possible routes for developing these methods to address future research questions. The results indicate substantial variations in tweet frequency over time and geographical regions, as well as differences in r

Within cognitive science, “blindness” to choice is commonly treated as typical of human cognition, implying unreliable agents who essentially lack any awareness of their own choices (e.g. Johansson et al., 2005, 2008; Hall et al., 2010, 2013). Within cognitive semiotics, however, choice awareness is seen as a continuous phenomenon, which is susceptible to the influence of a variety of factors. Man

Popular Abstract in Swedish I mitt doktorandprojekt har jag studerat den fästingspridda bakterien Borrelia och dess värddjur skogssork. Det övergripande syftet har varit att kartlägga den genetiska variationen i den delen av immunförsvaret som tar hand om bakterieinfektioner, som till exempel borrelia. I alla ryggradsdjur finns ett specifikt immunförsvar som kan identifiera små proteinbitar från eThe major histocompatibility complex (MHC) class IIB genes exhibit extensive allelic polymorphism, most likely maintained by pathogen-mediated balancing selection (PMBS). PMBS may operate in the form of heterozygote advantage (HA), and/or through the interaction of pathogens and specific MHC alleles via fluctuating selection (FS) or negative frequency-dependent selection (NFDS). In particular, NFD

Streptococcus pyogenes, an important human pathogen, expresses several proteins that interact with the immune system of the host. Among the proteins isolated from different bacterial strains are antiphagocytic M proteins, Ig Fc-binding proteins and exotoxins that act as superantigens. Here we report a novel interaction between S. pyogenes and the human immune system, the ability of most S. pyogene

Observations of binaries containing pairs of neutron stars using the upcoming space-based gravitational wave observatory, LISA, have the potential to improve our understanding of neutron star physics and binary evolution. In this work, we assess the effect of changing the model of the Milky Way’s kinematics and star formation history on predictions of the population of double neutron stars that wi

Protein dynamics on the micro- to millisecond time scale is increasingly found to be critical for biological function, as demonstrated by numerous NMR relaxation dispersion studies. Methyl groups are excellent probes of protein interactions and dynamics because of their favorable NMR relaxation properties, which lead to sharp signals in the H-1 and C-13 NMR spectra. Out of the six different methyl

After a brief discussion on the varying nomenclature applied to the field, this article discusses the two basic orientations: academic and applied. From there, the discussion takes up the sprawling character of the field, underscoring that the field can be conceptually organized in a variety of ways. The main part of the discussion consists of a presentation of four major schools of thought. These