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Nanosecond to Microsecond Protein Dynamics Probed by Magnetic Relaxation Dispersion of Buried Water Molecules
Large-scale protein conformational motions on nanosecond – microsecond time scales are important for many biological processes, but remain largely unexplored because of methodological limitations. NMR relaxation methods can access these time scales if protein tumbling is prevented, but the isotropy required for high-resolution solution NMR is then lost. However, if the immobilized protein molecule
Biomolecular hydration: from water dynamics to hydrodynamics.
Thermally driven rotational and translational diffusion of proteins and other biomolecules is governed by frictional coupling to their solvent environment. Prediction of this coupling from biomolecular structures is a longstanding biophysical problem, which cannot be solved without knowledge of water dynamics in an interfacial region comparable to the dry protein in volume. Efficient algorithms ha
Cell intrinsic alterations underlie hematopoietic stem cell aging
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties of highly purified long-term hematopoietic stem cells (LT-HSCs) from young and old mice. We found t
Allman-studieplan-klinisk-medicin-2015-01-01
Microsoft Word - Allm studieplan klin med 2015.doc Postadress Box 117, 221 00 LUND Telefon växel 046-222 00 00 Telefax 046-222 41 70 E-post info@med.lu.se Internet http://www.med.lu.se Medicinska fakultetsstyrelsen Allmän studieplan för utbildning på forskarnivå i klinisk medicin (Fastställd av Medicinska fakultetsstyrelsen 2007-‐05-‐24) Studieplanen träder ikraft
https://www.intramed.lu.se/sites/intramed.lu.se/files/2022-12/allman-studieplan-klinisk-medicin-2015-01-01.pdf - 2026-05-30
Forsakringsvillkor-diners-club-tac
– 1 (5)– D C 1 06 1 12 -0 1 Försäkringsvillkor för kompletterande rese försäkring för Diners Club TAC utfärdad av Trygg Hansa Gäller för resor köpta från och med den 1 januari 2012. Försäkring nr: TH0107-1 Information Försäkringsförmånerna gällande för Diners Club TAC nedan kallat Resekontot. När du som resekontoinnehavare använder Resekon- tot för att betala en resa, och betalar minst 75% av resa
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/forsakringsvillkor-diners-club-tac.pdf - 2026-05-30
Patterns of Prominence in L2 : Observations from Learners of Swedish with L1S of Diverse Prominence Properties
Swedish has – like other Germanic languages – flexible stress placement, which underlies morphological rules and is also based on the individual word’s origin. The achievement of the correct usage when learning Swedish is challenging. As second language learners of Swedish in the classrooms present speakers of a variety of first languages (L1s), the opportunity has been taken to have a closer look
Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. Since galectins have been implicated in mechanisms of both chronic inflammation and cancer, we have inves
The heart of metaphysical pluralism and the consistency dilemma – a critical analysis of the possibility of incompatible truths
Time Scales of Conformational Gating in a Lipid-Binding Protein
Lipid-binding proteins Sequester amphiphilic molecules in a large internal : cavity occupied by similar to 30 water molecules, some of which are displaced by the ligand. The role; of these internal water molecules in lipid binding and release is not understood. We use magnetic relaxation dispersion (MRD) to directly monitor internal-water dynamics in apo and palmitate-bound rat intestinal fatty ac
Vowel-to-vowel coarticulation in Japanese: The effect of consonant duration (L)
This paper examines vowel-to-vowel lingual coarticulation in sequences of vowel-bilabial consonant-vowel, where the duration of the oral closure for the consonant is either long or short. Native speakers of Japanese served as subjects. The linguistic material consisted of Japanese word pairs that only differed in the duration of the labial consonant, which was either long or short. Recordings were
Prescribing, Recording, and Reporting External Beam Therapy a Summary of ICRU Reports Nos 29, 50, 62 and 71
This presentation is a summary and a discussion of the ICRU Reports Nos 29, 50, 62 and 71.
Does the Dynamic Stokes Shift Report on Slow Protein Hydration Dynamics?
The time-dependent fluorescence frequency shift of protein-attached probes has a much slower decay than that for the free probe. The decay times, ranging from 10 ps to several nanoseconds, have been attributed to hydration water motions several orders of magnitude slower than those in the hydration shell of small solutes. This interpretation deviates strongly from the prevailing picture of protein
A comparison between human perception and a speaker verification system score of a voice imitation.
The international policy and regulatory challenges of food security: An overview
Quantum-Optical Signatures of Stimulated Emission
Joining Forces to Save the Nation : Corporate Educational Governance in Republican China
This chapter reassesses the modernization processes at work in Republican China during the Warlord period between 1911 and 1927 by focusing on corporate, public action by non-state interest groups and organizations. In particular, it looks at modes of corporate governing at the interface of business/economy and education: the realm of vocational education. The chapter examines a particularly illum
