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Coagulation and inflammation-close allies in health and disease.

The integrity of our bodies is under constant threat by external forces. Blood coagulation and inflammatory pathways are important, highly efficient defence systems that support health and well-being in both normal and challenged conditions. Being potentially dangerous for the own organism, they are kept under strict control by anticoagulant and anti-inflammatory mechanisms. Coagulation and inflam

Negation and approximation as configurational construals in SPACE

This article is a window into conceptual space through antonyms, negated antonyms and antonyms modified by degree modifiers. It investigates native speakers’ understanding of negation in combination with BOUNDED antonymic adjectival meanings and also in relation to their interpretations of the approximating degree modifier, ‘almost’ in Swedish. The results of the investigation are compared with a

Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins

Pathogenic microbes have evolved sophisticated molecular strategies to subvert host defenses. Here we show that virulent bacteria interfere directly with Toll-like receptor (TLR) function by secreting inhibitory homologs of the Toll/interleukin-1 receptor (TIR) domain. Genes encoding TIR domain containing–proteins (Tcps) were identified in Escherichia coli CFT073 (TcpC) and Brucella melitensis (Tc

Balde, Jacobus

In the frame of an encyclopedic article, a surview of the famous baroque Jesuit author Jacob Balde's life and his diverse oeuvre of Latin poetry is given.

The Tie that Binds: Cosmopolitan Obligation and the Primacy of Institutions

I identify what I see as three aspects of contemorary cosmopolitan philosophy: A certain moral consciousness, a commitment to moral universalism, and an institutional implication of the first two. The third of these is often regarded as a fall-out or consequence of the other two. I argue instead that the institutional aspect should be regarded as primary and that a distinctive feature of cosmopoli

The Metonymic Access of Emotion Concepts

Examples from the affective domain have been plentifully employed for illustrating and sustaining the claims of the conceptual metaphor theory (Lakoff 1980, 1992, Kövecses 1986, 1990, 2000, King 1989, Yu 1995, Matsuki, 1995, Soriano-Salinas 2003, etc.). According to this position, affective concepts (as many other abstract concepts) are metaphorically structured, i.e. conceptualized in terms of mo

Knowledge spillover agents and regional development

It is widely recognised that knowledge and highly-skilled individuals as “carriers” of knowledge (i.e. knowledge spillover agents) play a key role in impelling the development and growth of cities and regions. In this chapter we discuss the relation between the mobility of talent and knowledge flows. In this context, several issues are examined, including the role of highly-skilled labour for regi

Black widow pulsars: the price of promiscuity

The incidence of evaporating `black widow' pulsars (BWPs) among all millisecond pulsars is far higher in globular clusters than in the field. This implies a special formation mechanism for them in clusters. Cluster millisecond pulsars in wide binaries with white dwarf companions exchange them for turnoff-mass stars. These new companions eventually overflow their Roche lobes because of encounters a

The unstable Almanac : Transformations of the Almanac in Denmark in the Eighteenth and Nineteenth Centuries

Printed almanacs in the Danish language are preserved from the sixteenth century. The production of almanacs increased from the 1570’s just as that of news sheets, pamphlets, and chapbook stories. From the beginning the almanac covered a sheet of paper consisting of 16 leaves, or 32 pages. As a supplement, four or eight leaves of paper contained the Practica Astroligica. This form – 40 or 48 pages