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Nothing but NETs : Cytokine adsorption correlates with lower circulating nucleosomes and is associated with decreased primary graft dysfunction

Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of

The historical process of commercialization of cities: the case of Stockholm 1900-2020

The aim of this paper is to outline a process-based approach to the historical trajectory of commercialising cities that can account for continuity and change in a city’s image. Previous research involving historical approaches to the commercialisation of places are typically underpinned by a view of history as linear and chronological. By contrast, the present study adopts a performative view of

Ethopoeia as a progymnasma

An ethopoeia is an imagined speech assigned to a certain character. As a rhetorical exercise it is known from the progymnasmata of Theon, Hermogenes, Aphthonius and Nicolaus as well as contemporary rhetorical theorists. The purpose of the exercise was to teach the student the appropriate use of ethos and pathos for the assigned character. The paper will present the function of the ethopoeia as a p

Nitric oxide synthase in female reproductive and urinary organs: Hormonal regulation and functional significance

Popular Abstract in Swedish Nobelpriset i fysiologi och medicin 1998 gick till tre forskare från USA som gjort forskningsinsatser för upptäckten av kväveoxid (NO) vilket är en viktig signalsubstans i våra kroppar. Upptäckten av att en så liten molekyl som NO har så många funktioner i kroppen anses som en av de mest överraskande i medicinhistorien. Redan 1876 började man använda nitroglycerin som eNitric oxide synthase (NOS) activity was studied in cytosolic and particulate fractions in reproductive organs from rabbit (uterus and vagina) and rat (uterus, vagina and cervix). NOS was found predominantly in cytosolic fractions in all tissues and the activity of NOS in both fractions was highly Ca2+ dependent. NOS activity in vagina and cervix were much higher (3-6-fold) than in the uterus. Est

The “Light” and the process of the cognition

This paper analyses the internal structure of the terminology of the Enlightenment, actually the process of forming the term “enlightenment” itself within the Indo-European languages and beyond this language family. We use the methodological concept found in the cognitive linguistics on the research of metaphorical extension of lexically meaning of the stem, light, and other morphemes forming the

The role of the MAP- and SAP- kinase pathways in the survival, proliferation and death of Schwann cells of the injured sciatic nerve.

Popular Abstract in Swedish Den här avhandlingen behandlar främst Schwannceller och hur de reagerar på en nervskada. Schwannceller omger alla nervtrådar i det perifera nervsystemet det vill säga det nervsystem som ligger utanför hjärna och ryggmärg och innerverar armar, ben, händer och fötter och så vidare. Schwannceller och ger dessa tillgång till de näringsämnen de behöver. De städar också upp sThis thesis concerns alterations in signal transduction in Schwann cells as a response to nerve injury as well as their survival, proliferation and death. Enzymes and transcription factors belonging to the mitogen activated protein kinase (MAPK) and the stress activated protein kinase (SAPK) pathways were studied. This included the extracellular-signal-regulated kinase 1/2 (ERK1/2), c-Jun N-termin

Neural Network Ensembles and Combinatorial Optimization with Applications in Medicine

Popular Abstract in Swedish Inom medicin, och inom många andra tillämpningar, är uppgiften ofta att utifrån en serie observationer ge ett jakande eller nekande svar på en viss fråga. Exempelvis måste en läkare avgöra om en patient med bröstsmärtor lider av akut hjärtinfarkt eller inte. Artificiella neurala nätverk är en sorts datorprogram som själv förmår "lära" sig att svara på sådana frågor. NäArtificial neural network (ANN) and combinatorial optimization algorithms are developed, and applied to the medical domain. A novel method for training an ensemble of ANN is presented, based on random weight updates alternated with replication of networks with low error. The evolution of the ensemble is explored, with particular emphasis on its diversity and internal correlation. The performance