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Observations in vivo in patients, supported by guinea-pig in vivo data, take centre stage in this perspective. Its objective is to highlight dichotomies between asthma features observed in vivo and accepted views involving cell/molecular biology research paradigms. For example, increased bronchial epithelial permeability is now considered a major paradigm and trait of asthma, yet, absorption of in

Objectives: To assess the health-related quality of life (HRQOL) of patients with mucopolysaccharidosis (MPS) and their caregivers and to quantify the disease-related costs from a societal perspective. Methods: In the context of a multi-country study of rare diseases (BURQOL-RD project), a cross-sectional survey was performed among MPS patients in seven European countries. Data on demographic char

The Augustan poet Ovid (43 BC – AD 17/18) is mentioned by Seneca the elder for his oratorical skills as a school boy. If we are to believe Seneca, Ovid excelled to such a degree that he even surpassed his teachers. He took special interest in exercises concerning ethos, and is said to have transferred what he learned into his own verse. The influence from rhetorical training is indeed visible in O

Abstract not available

Historia förmedlas ofta på ett inflytelserikt sätt på film. I "World War II at 24 Frames a Second" jämförs filmiska representationer av andra världskriget i Danmark, Norge och Sverige med fokus på den senaste tioårsperioden.

The erection of roadside memorials in Sweden is commonly considered a novel practice, appearing during the last 10-15 years. Nevertheless similar precedent practices can be found in the history of Sweden. Stories about marking the site of an unexpected death with a cross could be said to date back to the eleventh century legend of Saint Sigfrid, telling of the first English missionary to spread C

We propose a new dynamic and efficient bounding volume hierarchy for breakable objects undergoing structured and/or unstructured motion. Our object-space method is based on different ways to incrementally update the hierarchy during simulation by exploiting temporal coherence and lazy evaluation techniques. This leads to significant advantages in terms of execution speed. Furthermore, we also show

Background: People with psychosis have a reduced life expectancy of 10-20years, largely due to cardiovascular disease. This trial aimed to determine the effectiveness of a modular health promotion intervention (IMPaCT Therapy) in improving health and reducing cardiovascular risk in psychosis. Methods: A multicentre, two arm, parallel cluster RCT was conducted across five UK mental health NHS trust

The introduction of paid holidays during the interwar years democratized travel and laid the foundation for modern mass tourism. In European democracies, the right to paid leave found supporters from across the political spectrum who viewed it a means to improve the health of the labor force, increase industrial output, and safeguard family values. Workers also gained new leisure opportunities in