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En åpen og opplyst offentlig samtale er en forutsetning for et velfungerende demokrati. Dette idealet fordrer at borgere i stor grad tolererer meningsmotstandere fremfor å utvikle fiendtlige holdninger til dem man er uenig med. En rekke studier fra USA har imidlertid vist at borgere i økende grad er fiendtlig innstilt til velgere de er politisk uenig med (Iyengar et al., 2019). Dette fenomenet er

Asymptotics of Maximum Likelihood Parameter Estimates For Gaussian Processes: The Ornstein–Uhlenbeck Prior

This article studies the maximum likelihood estimates of magnitude and scale parameters for a Gaussian process of Ornstein-Uhlenbeck type used to model a deterministic function that does not have to be a realisation of an Ornstein- Uhlenbeck process. Specifically, we derive explicit expressions for the limiting values of the maximum likelihood estimates as the number of observations increases. The

GATA2 at the mitosis-to-G1 transition is critical for definitive hematopoiesis

In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role

Nonexistence of Subcritical Solitary Waves

We prove the nonexistence of two-dimensional solitary gravity water waves with subcritical wave speeds and an arbitrary distribution of vorticity. This is a longstanding open problem, and even in the irrotational case there are only partial results relying on sign conditions or smallness assumptions. As a corollary, we obtain a relatively complete classification of solitary waves: they must be sup

Intensivvård efter hjärtstopp

In Sweden 1600 patients/year survive cardiac arrest (30-day survival). Post-resuscitation care is complex and aims to stabilize organ function with focus on preventing secondary brain injury. In 2021 The European Resuscitation Council (ERC) and European Society of Intensive Care Medicine (ESICM) published joint guidelines on post-resuscitation care. In this article the Swedish Resuscitation Counci

Recommendations for Deprescribing of Medication in the Last Phase of Life : An International Delphi Study

Context: Medications may become inappropriate for patients in the last phase of life and may even compromise their quality of life. Objective: To find consensus on recommendations regarding deprescribing of medications for adult patients with a life expectancy of six months or less. Methods: Experts working in palliative care or other relevant disciplines were asked to participate in this internat

Evaluation of the cross-corrugated and some other candidate heat transfer surfaces for microturbine recuperators

To achieve high thermal efficiencies, 30 percent and higher, for small gas turbines a recuperator is mandatory. As the recuperator represents 25–30 percent of the overall machine cost, efforts are now being focused on establishing new low-cost recuperator concepts for gas turbine engines. In this paper the cross corrugated (CC), also called chevron pattern, heat transfer surface is reviewed to ass