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The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

Background: The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in many indications, the toxicities of the current treatment regimens may limit their use. Thus, there is a medical need for new CTLA-4 targeting therapies wit

The temple attitudes of John and Qumran in the light of Hellenistic Judaism

Den bortglömda socialgruppsindelningen

Kan historievetenskap se ut så här?

Om gåshud : Hopp om en värld av grannar

Till bildningens försvar

Ectodermal patterning in the avian embryo: epidermis versus neural plate

Ectodermal patterning of the chick embryo begins in the uterus and continues during gastrulation, when cells with a neural fate become restricted to the neural plate around the primitive streak, and cells fated to become the epidermis to the periphery. The prospective epidermis at early stages is characterized by the expression of the homeobox gene DLX5, which remains an epidermal marker during ga

Ptychographic Nano-Analytical Microscope (PtyNAMi) at PETRA III : Signal-to-background optimization for imaging with high sensitivity

The X-ray scanning microscope PtyNAMi at beamline P06 of PETRA III at DESY in Hamburg, Germany, is designed for high-spatial-resolution 3D imaging with high sensitivity. Besides optimizing the coherent ux density on the sample and the precision mechanics of the scanner, special care has been taken to reduce background signals on the detector. The optical path behind the sample is evacuated up unti

Synthesis of Surfactants Using Enzymes

Year-9 Students' Use of their Background Languages while Writing in English

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The impact and outcome of knowledge sharing: A study of IKEA´s efforts to (re-)enter the Japanese market

Dialogical Faithless

Handwriting or Typing : a comparative study

Innovation policy for knowledge production and R&D

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En åpen og opplyst offentlig samtale er en forutsetning for et velfungerende demokrati. Dette idealet fordrer at borgere i stor grad tolererer meningsmotstandere fremfor å utvikle fiendtlige holdninger til dem man er uenig med. En rekke studier fra USA har imidlertid vist at borgere i økende grad er fiendtlig innstilt til velgere de er politisk uenig med (Iyengar et al., 2019). Dette fenomenet er

Asymptotics of Maximum Likelihood Parameter Estimates For Gaussian Processes: The Ornstein–Uhlenbeck Prior

This article studies the maximum likelihood estimates of magnitude and scale parameters for a Gaussian process of Ornstein-Uhlenbeck type used to model a deterministic function that does not have to be a realisation of an Ornstein- Uhlenbeck process. Specifically, we derive explicit expressions for the limiting values of the maximum likelihood estimates as the number of observations increases. The

Novel miR-29 mitochondrial-associated gene pathways predicted to regulate beta cell insulin secretion

GATA2 at the mitosis-to-G1 transition is critical for definitive hematopoiesis

In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role