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Background: The general population is exposed to phthalates, a group of chemicals with strong evidence for endocrine disrupting properties, commonly used in a large number of consumer products. Based on published research and evidence compiled by environmental agencies, certain phthalate applications and products have become restricted, leading to an increasing number of “new generation compounds”
Background: Pneumococcal vaccination is recommended to patients with rheumatoid arthritis (RA) and primary Sjögren’s syndrome (pSS). However, little is known whether the diseases influence pneumococcal vaccine response. This study aimed to investigate antibody response and functionality of antibodies following immunization with 13-valent pneumococcal conjugate vaccine (PCV13) in RA patients or pSS
Retail and cities have had a long and intertwined history together. Since the beginning of first cities established, being a hub for commercial exchange has been one of the main elements what makes a city (Söderlind, 2011). Nevertheless, since 1980s, there have been some substantial shifts at the global scale regarding the organization of retail, and in turn, its spatial manifestations in the citi
BACKGROUND: Caffeine is believed to be neuroprotective in preterm and term infants, despite the conflicting data on its effects on the developing brain in animal models. We aimed to conduct a systematic review with meta-analysis assessing the effects of caffeine on the prevention and treatment of neurological morbidity caused by hypoxic-ischemic encephalopathy (HIE) in preclinical studies.METHODS:
Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual
Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma eligible for both anti-IgE and anti-IL5/5R and to compare the effectiveness of both classes of treatment in real life. Methods: This was a prospective cohort s
Post-acute COVID-19 (PACS) are associated with cardiovascular dysfunction, especially postural orthostatic tachycardia syndrome (POTS). Patients with PACS, both in the absence or presence of POTS, exhibit a wide range of persisting symptoms long after the acute infection. Some of these symptoms may stem from alterations in cardiovascular homeostasis, but the exact mechanisms are poorly understood.
Background: Impaired gait can precede dementia. The associations between gait parameters and brain pathologies are therefore of interest. Objective: To explore how different brain pathologies (i.e., vascular and Alzheimer's) are associated with specific gait parameters from various gait components in persons with mild cognitive impairment (MCI), who have an increased risk of developing dementia. M
Purpose: With modern treatments, mantle cell lymphoma (MCL) patients more frequently experience long-lasting remission resulting in a growing population of long-term survivors. Follow-up care includes identification and management of treatment-related late-effects, such as secondary malignancies (SM). We conducted a population-based study to describe the burden of SM in MCL patients. Methods: All
We report here the complete genome sequence and characterization of Yersinia bacteriophage vB_YenP_ϕ80-18. ϕ80-18 was isolated in 1991 using a Y. enterocolitica serotype O:8 strain 8081 as a host from a sewage sample in Turku, Finland, and based on its morphological and genomic features is classified as a podovirus. The genome is 42 kb in size and has 325 bp direct terminal repeats characteristic
Background: Defining the origin of genetic novelty is central to our understanding of the evolution of novel traits. Diversification among fatty acid desaturase (FAD) genes has played a fundamental role in the introduction of structural variation in fatty acyl derivatives. Because of its central role in generating diversity in insect semiochemicals, the FAD gene family has become a model to study
Background: Bilberries from Sweden, rich in polyphenols, have shown cholesterol-lowering effects in small studies, and the cholesterol-lowering properties of oats, with abundant beta-glucans and potentially bioactive phytochemicals, are well established. Both may provide cardiometabolic benefits following acute myocardial infarction (AMI), but large studies of adequate statistical power and approp
Conjugation with poly(ethylene glycol) ("PEGylation") is a widely used approach for improving the therapeutic propensities of peptide and protein drugs through prolonging bloodstream circulation, reducing toxicity and immunogenicity, and improving proteolytic stability. In the present study, we investigate how PEGylation affects the interaction of host defense peptides (HDPs) with bacterial lipopo
Abstract. Objectives. To ascertain whether a relationship exists between the PiZ alpha1‐antitrypsin (α1AT) variant and antineutrophil cytoplasm antibodies (ANCA)‐positive vasculitis in a large group of Swedish patients, and whether analysis for the presence of the PiZ variant might be useful for diagnostic or prognostic purposes. Design. Retrospective cross‐sectional study. Setting. The Departmen
Background: There is a call for valid and reliable instruments to evaluate implementation of evidence-based practices (EBP). The 15-item Evidence-Based Practice Attitude Scale (EBPAS) measures attitude toward EBP, incorporating four lower-order factor subscales (Appeal, Requirements, Openness, and Divergence) and a Total scale (General Attitudes). It is one of a few measures of EBP attitudes evalu
Subsistence farmers in the developing world are one of the most vulnerable groups to the impacts of climate change. Strengthening their adaptive capacity requires information to inform their climate and agricultural-related decisions. Climate information services offer great potential to inform farmers’ decision-making, enabling households to strengthen their ability to manage climate-related risk
I Sverige finns det en nödvärnsrätt som ger en person rätt till ansvarsfrihet när denna försvarat sig mot ett brottsligt angrepp på sin person. Denna rätt har dock kritiserats för att vara utformad att fungera bättre i typiskt sett manliga våldssituationer, d.v.s. då en man attackeras av en annan för honom okänd man. Situationer då den fungerar sämre har ansetts vara då kvinnor använt dödligt våld
Den sakkunniges roll är att hjälpa domstolen vid bevisvärderingen genom att tillhandahålla sin sakkunnigkunskap. Det har i flera olika sammanhang framförts kritik mot att domstolar inte kritiskt granskar sakkunnigutlåtanden. Vid mål som rör våld med dödlig utgång utgör den rättsmedicinska obduktionsrapporten en viktig del i bevisningen. Ur rättssäkerhetssynpunkt är det viktigt den rättsmedicinska
Uppsatsen undersöker hur rättsfiguren ”urminnes hävd”, som enligt 1 § rennäringslag (1971:437) utgör grunden för samernas renskötselrätt, har hanterats i fem statliga utredningar om renskötande samers markrättigheter under perioden 1886 – 2006. Utredningarna betraktas som fem historiskt präglade uppfattningar om samers rätt, men inte som representationer av samtliga diskussioner som under tidsperiThis bachelor’s thesis investigates five government inquiries regarding property rights for reindeer husbandry during the period 1883 to 2006. It looks at how the legal entity “urminnes hävd” (prescription from time), which according to 1 § Reindeer Husbandry Act (1971:437) constitutes the legal basis for the Saami peoples’ husbandry rights, has been applied during the period. The aim is to resear
Sexleksaker är inget nytt fenomen. Det är en industri som har funnits länge och precis som med all annan industri så har den utvecklats. Även om sexdockan inte är ett nytt fenomen så har den kommit att få en helt ny innebörd. Utvecklingen har gått från den klassiska uppblåsbara ”Barbara” till en högteknologisk docka i material som ger en verklighetstrogen känsla och som ska ge maximal njutning tilSex toys are not a new phenomenon. It is an industry that has been around for a long time and just as with any other industry it has developed. Although sex doll as a toy is not a new phenomenon, it has come to have a whole new meaning. The development has gone from the classic inflatable "Barbara" to a high-tech doll in materials that give a real-life feeling and which is supposed to gi
