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BACKGROUND: Blood-based biomarkers have the potential to reflect cerebrovascular signaling after microvascular injury; yet, the detection of cell-specific signaling has proven challenging. Microvesicles retain parental cell surface antigens allowing detection of cell-specific signaling encoded in their cargo. In ischemic stroke, the progression of pathology involves changes in microvascular signal

Popular Abstract in Swedish Inom hälso- och sjukvården betonas att vården ska ges utifrån ett patientorienterat sätt. Om sjuksköterskor skall kunna ge patienten god omvårdnad, måste de själva ha en god arbetssituation. Det blir allt vanligare att sjuksköterskor i arbetet utsätts för en mängd negativa psykiska påfrestningar, såsom hot och våld, som kan leda till stress. Stress kan också relateras tThe purpose of group supervision in nursing care is to understand nurses’ experiences from real care settings and to structure these in a professional and personal context. An interventional and longitudinal method of research was chosen in this study of group supervision in nursing care. The overall aim of the present study was to examine and investigate how psychiatric nurses’ professional compe

Popular Abstract in Swedish Varje år drabbas i världen ca 3 miljoner individer av cancer i mag-tarmkanalen. Stora skillnader finns i incidens med magsäckscancer och matstrupscancer särskilt vanliga i utvecklingsländer, medan tjock- och ändtarmscancer är en av de vanligaste tumörtyperna i västvärlden. Cancer i mag-tarmkanalen ger ofta diffusa symtom, vilket i många fall leder till att tumörerna uppEsophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. This thesis aimed to genetically profile esophageal cancer with c

Aims: We tested whether autoantibodies to all three ZnT8RWQ variants, GAD65, insulinoma-associated protein 2 (IA-2), insulin and autoantibodies to islet cell cytoplasm (ICA) in combination with human leukocyte antigen (HLA) would improve the diagnostic sensitivity of childhood type 1 diabetes by detecting the children who otherwise would have been autoantibody-negative. Methods: A total of 686 pat

This dissertation explores how son preference is constructed and renegotiated in light of social change in the People’s Republic of China (PRC). Based on secondary sources and interviews with women and men in rural Anhui Province as well as key informants, it addresses son preference from conceptual, methodological, empirical and ideological perspectives. The analysis centres around son preference

Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. The aim of this

ABSTRACT: We plan to conduct a case-control study to investigate whether exposure to nitrogen dioxide (NO2) increases the risk of stroke. In case-control studies, selective participation can lead to bias and loss of efficiency. A two-phase design can reduce bias and improve efficiency by combining information on the non-participating subjects with information from the participating subjects. In ou

The word “desertification” was introduced in 1949 by the French scientist Aubreville in his report “Climats, forêts et désertification de l´Afrique tropicale”. The concept, however, was discussed earlier by European and American scientists in terms of increased sand movements, desiccation, desert and Sahara encroachment and man made deserts. Desertification, at the beginning of last century, mea

AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts dev

To every analytic function $g$ in the unit disk $\bold D$ one associates the integral operator $T_g(f)(z)\coloneq z^{-1}\int^z_0f(\xi)g'(\xi)d\xi$ on spaces of analytic functions in $\bold D$. Operators of this form appear naturally in complex analysis. For instance, the choice $g(z)\equiv z$ leads to the integration operator, and the choice $g(z)=\log(1/(1-z))$ leads to the Cesàro operator. The

Popular Abstract in Swedish Den molekylära processen under vilken DNA-information förs över till RNA-information kallas transkription. Transkription styrs främst i samverkan med många speciella molekyler som kallas transkriptionsfaktorer. Zinkfinger proteiner är en av de vanligast förekommande klasserna av reglerande proteiner i eukaryota celler där de inverkar på en mängd av cellulära aktiviteterThe molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. A classical zinc finger is a small protein motif with a simple

Popular Abstract in Swedish I denna avhandling presenteras fyra nya metoder för att automatiskt mäta hjärtats förmåga att pumpa ut blod i kroppen, mäta storleken på en hjärtinfarkt samt mäta hur stor del av hjärtmuskeln som riskerade att dö vid hjärtinfarkten. Dessa nya metoder kan användas för att minska skillnader mellan mätningar gjorda av olika läkare, på olika sjukhus och i olika forskargruppIn this thesis four new algorithms are presented for automatic segmentation in cardiovascular magnetic resonance (CMR); automatic segmentation of the left ventricle, myocardial infarction, and myocardium at risk in two different image types. All four algorithms were implemented in freely available software for image analysis and were validated against reference delineations with a low bias and hig

It is easy when studying the literature on the current development toward closer more integrated business to business relationships to get the impression that a close integrated relationship is desired for all circumstances. Instead, this thesis shows that the nature of business relationship is very strongly correlated to product supplied. The focus of this thesis has been a case study between a s

Surfactant self-assembly is an important phenomenon that occurs in a number of processes in our everyday life. It is important to understand the forces and parameters that control and influence the self-assembly, as this knowledge can be used both in order to design surfactant systems with desired properties and for creating model systems, for example for biological processes. The papers of this t

The humoral immune response to a T cell dependent protein antigen will over time generate antibodies with an increased affinity to the antigen. This is due to a process known as affinity maturation and proceeds in a, for this purpose, well designed micro-milieu within secondary lymphoid organs known as germinal centres. The increase in affinity of an antibody in, e.g. mouse and man is due mainly t

This thesis is devoted to fundamental aspects, and to spectroscopic applications of radiative properties in free atoms and ions, as well as in ions doped into crystals. Using the time-resolved laser-induced fluorescence technique, measurements of radiative lifetimes for rare earth elements have been performed in neutral Pr, Nd, Tm, and in singly ionized Sm, Er, Nd, Tm, Yb, as well as in doubly io

Popular Abstract in Swedish Denna avhandling presenterar en metod som kan hantera generella tjocka frekvensselektiva strukturer (FSS). Metoden är baserad på modanpassning och finita elementmetoden (FEM). Avhandlingen är en sammanläggningsavhandling och består av en introduktion som följs av fem vetenskapliga artiklar. Frekvensselektiva strukturer fungerar som filter för elektromagnetiska vågor, sThis thesis presents a new method that can handle a general thick Frequency Selective Structure (FSS), that consists of an arbitrary number of aperture layers and dielectric layers. The method is based on the Mode Matching Technique (MMT) and the finite element method (FEM). The thesis consists of a General Introduction and five scientific papers. The General Introduction gives an overview of fil

Popular Abstract in Swedish I en komponent som utsätts för upprepande på- och avlastningar, d.v.s. cyklisk belastning, kan defekter i form av sprickor initieras och börja växa. Detta fenomen kallas utmattning och kan leda till haveri med potentiellt katastrofala följder. Det är därför viktigt att förstå fenomenen som ligger bakom utmattning och att ha tillförlitliga modeller för att förutsäga livsUnderstanding of the growth of fatigue cracks is of utmost importance since such growth often has a profound influence on the life of components subjected to cyclic loading. Thus, reliable fatigue life models enable a more efficient use of materials and improve the performance and efficiency in many applications. This thesis deals with the growth of fatigue cracks subjected to high load amplitude

Previous studies on the occurrence of catecholamines and serotonin in pancreatic islets using various histochemical and chemical methods have given widely different results. We therefore performed a comparative analysis of these amines in whole pancreas and islet tissue from hamster, guinea pig, rat, and mouse by the use of high performance liquid chromatography. Whole pancreas of guinea pig, hams

In this prospective, case-control study, femoral neck diameter, cross-sectional moment of inertia, or section modulus was an independent predictor of hip fracture risk after adjustment for BMD. However, the contribution of each of these indices to hip fracture prediction was modest in the presence of BMD. Introduction: The relative contribution of measures of hip strength to hip fracture predictio