Filtyp
We review approaches to predicting carbon and nitrogen allocation in forest models in terms of their underlying assumptions and their resulting strengths and limitations. Empirical and allometric methods are easily developed and computationally efficient, but lack the power of evolution-based approaches to explain and predict multifaceted effects of environmental variability and climate change. In
Popular Abstract in Swedish Östrogen är ett av de viktigaste/ mest studerade kvinnliga könshormonerna som styr utvecklingen av våra fortplantningsorgan och deras reproduktionsförmåga. Östrogen påverkar dessutom många av kroppens andra organ, bland annat hjärnan, skelettet, och hjärt-kärlsystemet. Mängden östrogen som finns i kroppen varierar vanligtvis under menstruationscykeln och med kvinnans ålEstrogen effects are mediated either through genomic action involving the classical estrogen receptors, estrogen receptor alpha (ERα) and beta (ERß), which function as transcription factors in the nucleus, or through rapid non-genomic action via receptors associated with plasma membrane. Recently, a member of the G protein-coupled receptor family was ascribed estrogen receptor properties and propo
Background: SoPIP2;1 constitutes one of the major integral proteins in spinach leaf plasma membranes and belongs to the aquaporin family. SoPIP2;1 is a highly permeable and selective water channel that has been successfully overexpressed and purified with high yields. In order to optimize reconstitution of the purified protein into biomimetic systems, we have here for the first time characterized
Permafrost in peatlands of subarctic Sweden is presently thawing at accelerated rates, which raises questions about the destiny of stored carbon and nutrients and impacts on adjacent freshwater ecosystems. In this study we use peat and lake sediment records from the Stordalen palsa mire in northern Sweden to address the late Holocene (5,000 cal BP-present) development of the mire as well as relate
Background: The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. To further explore the mode of action of tasquinimod, in vitro and in vivo experiments with gene microarra
A carbon nanotube forest provides a unique non-stick surface for nanomanipulation, as the nanostructuring of the surface allows micro- and nanoscale objects to be easily removed after first being deposited via a liquid dispersion. A common problem for smooth surfaces is the strong initial stiction caused by adhesion forces after deposition onto the surface. In this work, carbon nanotube forests fa
Popular Abstract in Swedish Typ 2 Diabetes (T2D) räknas som en folksjukdom i Sverige vilket innebär att den är så vanlig att minst 4 % av befolkningen är drabbad. Förekomsten av diabetes ökar lavinartat över hela världen och man beräknar att så många som 300 miljoner människor har diabetes idag. Socker är en livsviktig energikälla, men lagom är bäst Socker i mat förs ut till blodet och används soType 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). The aim of this thesis has been to investigate functional and genetic events that
The 7th Ammendment to the Cosmetics Directive of the European Commission (Directive 76/768/EEC2) bans the marketing of cosmetics containing animal-tested ingredients since March 2009. Excepted are only tests for repeated dose toxicity, for which the animal ban will come into effect by 2013. One major concern for cosmetics, i.e. the risk of containing skin (contact) sensitizers, has in the past bee
Background Contact sensitisation has been identified as a factor associated with poor prognosis for patients with hand eczema. Objectives To study implications of contact sensitisation with respect to severity, quality of life (QoL) and subdiagnosis of hand eczema. Methods The study was performed as a multi-centre, cross-sectional study from 10 European clinics. All patients were patch tested, and
Purpose: To investigate detection performance for calcification clusters in reconstructed digital breast tomosynthesis (DBT) slices at different dose levels using a Super Resolution and Statistical Artifact Reduction (SRSAR) reconstruction method. Method: Simulated calcifications with irregular profile (0.2 mm diameter) where combined to form clusters that were added to projection images (1-3 clus
1. Within a single year, long-distance migrants undergo a minimum of four cycles of fuel storage and depletion because their migrations have at least one stopover. Each cycle includes an almost twofold change in body mass (m(b)). Pervasive predation threats beg the question whether escape flight abilities keep up with such large changes in m(b). 2. We derive aerodynamic predictions how pectoral mu
Introduction: Women with a history of preeclampsia have an increased risk for cardiovascular disease in later Life. We evaluated thrombogenic characteristics of women with a previous history of preeclampsia, expressed in levels of thrombin generation, number of micropartictes and related to menstrual cycle and endothelial function, measured as flow-mediated dilatation. Materials and methods: We in
OBJECTIVE: To compare the predictive accuracy of β-amyloid (Aβ)1-42 and total tau in CSF, hippocampal volume (HCV), and APOE genotype for Alzheimer disease (AD)-type dementia in subjects with amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI). METHODS: We selected 399 subjects with aMCI and 226 subjects with naMCI from a multicenter memory clinic-based coho
The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were p
The core protein of glypican-1, a glycosylphosphatidylinositol-linked heparan sulfate proteoglycan, can bind Cu(II) or Zn(II) ions and undergo S-nitrosylation in the presence of nitric oxide. Cu(II)-to-Cu(I)-reduction supports extensive and permanent nitrosothiol formation, whereas Zn(II) ions appear to support a more limited, possibly transient one. Ascorbate induces release of nitric oxide, whic
Abstract (1/2-em) Two-phase systems consisting of a polymer rich phase and polymer depleted phase, where the polymer is either ethyl(hydroxy ethyl)cellulose (EHEC) or Ucon (a random copolymer of ethylene oxide and propylene oxide), have been studied. Both of these polymers can be separated from an aqueous solution by either temperature increase or addition of cosolutes. The polymers are thermosepa
PURPOSE: To assess and analyze refractive outcome after cataract surgery in Sweden from 2008 though 2010. SETTING: Swedish cataract surgery units participating in outcome registration of National Cataract Register. DESIGN: Cohort study. METHODS: Planned and actual postoperative refractions were analyzed for cataract procedures and preoperative and postoperative corneal astigmatism for procedures p
Objective. To identify genetic factors driving pathogenic autoantibody formation in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA), in order to better understand the etiology of RA and identify possible new avenues for therapeutic intervention. Methods. We performed a genome-wide analysis of quantitative trait loci controlling autoantibody to type II collagen (anti-CI
OBJECTIVES: Numerous studies have shown associations between an on-going depression and elevated serum levels of the acute-phase reactant C-reactive protein (CRP). Also, in suicidal behaviour, a proinflammatory state has been suggested to be of importance for the pathophysiology. There is a genetic susceptibility to suicidal behaviour, but studies with respect to genes related to inflammation are
