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The identification of starting points for compound development is one of the key steps in early-stage drug discovery. Information-rich techniques such as crystallographic fragment screening can potentially increase the efficiency of this step by providing the structural information of the binding mode of the ligands in addition to the mere binding information. Here, we present the crystallographic

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Control based on image information offers great possibilities for advanced automation. Here, a flexible system for study of visual servoing has been developed by extending a standard computer with commercially available instrumentation. A robot moving on the floor is controlled by image feedback. The conclusion is that an industrially useful behavior of automated guided vehicles (AGV) in flexible

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ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente

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In the debate on how to make democracy strong against terrorism, it has been suggested that the Western democracies need new protective measures. This paper argues that, far from protecting democracy, such measures may in fact undermine the very values and virtues that make democracy possible. Information freedom, the right to due process and the protection of privacy are all fundamental for the

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Although a substantial body of theoretical as well as empirical work emphasizes the role of the mass media in constructing what could serve as a political public sphere at the European level, strikingly little is known, in qualitative terms, about opinion-making journalists’ underlying views and orientations on the European integration process. The point of departure in the present paper is that o

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In the cinemas of small European nations, infrastructural support systems aimed at endorsing and strengthening audiovisual production, tend to play an increasingly pivotal role. Since additional systems have been added, with the intent to, for instance, encourage co-production or to attract filming and post-production work to assorted places – and always coming with various provisions attached – o

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The purpose of the present study was to study associations between self-assessed alexithymia and sleep disorders. Five groups of patients with different sleep disorders were compared on the Toronto Alexithymia Scale (TAS-20). The prevalence of alexithymia, as defined by the cut-off score of TAS >60 was 17% among all patients, but differed among the groups: Primary Insomnia (PRI, n = 119) 6.7%, Ins

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The overall aim of the research presented in this thesis was to gain increased knowledge and understanding of aspects and actors that contribute to the preconditions and outcomes for proactive health and safety managementregarding vibration exposure. The main objectives were: 1) to investigate carpenters´ perceptions of the proactive health and safety management at their work sites, and 2) to carr

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This study aimed to deepen and refine the understanding of the responsibility burden that children may need to navigate in a family where a parent is grappling with alcohol abuse. Our research questions included “How is the responsibility that a child may need to assume for a parent with alcohol abuse portrayed in the autobiographies of adult children?” and “How is the responsibility one may need

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This project presents the design and development of “Breathe Right,” a wearable AI-powered device and app aimed at promoting a regulated and healthy breathing pattern. Our breathing pattern plays a significant role in both our physical and mental health. Even if we don’t realize it, there are proper and improper ways to breathe, and an unregulated breathing pattern can unconsciously harm our healt

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De så kallade ränteavdragsbegränsningsreglerna trädde ikraft 1 januari 2009 för att få bukt med den skatteplanering med räntor som koncernbolag använde sig av och som inte kunde kommas åt med skatteflyktslagen. Eftersom det även med dessa regler fanns stora möjligheter för koncernbolag att skatteplanera med interna lån skärptes reglerna från och med 1 januari 2013. I den lagstiftningen tillkoThe so-called interest deduction restriction rules entered into force on 1 January 2009 in order to overcome the tax planning regarding interest deductions used by group companies, that was not covered by the Tax Avoidance Act. Since these rules also provided opportunities for group companies to plan their taxes with internal loans the rules were tightened from 1 January 2013. In this new leg

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Described as a “paradigm shift” event (Michelson, 2020), the Covid-19 pandemic is challenging all humans activities worldwide. Such disruptive event can be labelled as a crisis, which is described as an episode of uncertainty threatening high priority goals (Sellnow & Seeger, 2013). Despite this critical situation, 206 different relevant elections has been held globally since February 2020 (ID

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Birds living in temperate regions face an energetically demanding period in winter, when food availability becomes reduced and unpredictable. In order to conserve energy, wintering passerines reduce their metabolic rate (MR) and body temperature (Tb) during the night to enter into a state of hypothermia. The effect of food predictability on the energy budget of birds is not fully understood. There

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Over the past few decades, employee engagement has been increasingly recognised as a key driver of organisational success. Although previous research has examined psychological and organisational factors influencing engagement, few studies have examined how it varies over time. This study explores the dynamic and sustainable aspects of employee engagement in Swedish organisations, focusing on how

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The structure-agency debate in the social sciences is pervasive in policymaking; in recent policy paradigms and in their consequent macro-level policies. The present study attempts to study how in the latest two policy paradigms, neoliberalism and social investment respectively, the structure-agency debate has undergone changes in Swedish Government Official Reports, which investigate the integrat

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This thesis attempts to study and explain Swedish school principals’ reactions to and perceptions of the auditing process of the Swedish School Inspectorate. Guided by two strands of institutional theory, rational choice and sociological institutionalism, the author identifies certain factors that can potentially affect how principals react and think about the auditing process. The study follows a