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For radionuclide therapy, individual patient pharmacokinetics can be measured in three dimensions by sequential SPECT imaging. Accurate registration of the time series of images is central for voxel-based calculations of the residence time and absorbed dose. In this work, rigid and non-rigid methods are evaluated for registration of 6-7 SPECT/CT images acquired over a week, in anatomical regions f
The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based o
In this work, we present the fabrication and investigation of the properties of quasi-vertical gallium nitride (GaN) fin field effect transistors (FinFETs) on silicon carbide (SiC) substrates and the influence of a postgate metallization annealing (PMA). The devices reveal low subthreshold swings (SSs) down to around 70 mV/dec. For a 1- $\mu \text{m}$ -thick drift layer, a low ON-resistance below
Many people use conspiracy theories to make sense of a changing world and its ever more complexif social structures (e.g., international financial systems, global bodies of governance), tragic events (e.g., terrorist attacks, man-made catastrophes, or natural disasters), or socio-political and economic issues (e.g., security, migration, distribution of resources, health care). The widespread flour
The rapid technological advancements of modern times have brought about the need for an innovative and contemporary approach to medical waste management procedures. This arises from the inadequacy of conventional manual techniques in ensuring the safety of employees and the environment from infections. The increasing amount of waste produced each day can exacerbate the situation if no action is ta
This thesis unfolds a journey into the realm of cloud integrated systems. More specifically, it explores the transformational role of diverse cloud infrastructure, be it public or private, centralized or edge-based, when integrated into traditional systems. In this transformation, the cloud assumes the vital role of controllers. Inevitably, this shift towards cloud integration also brings into pla
This doctoral thesis investigates changes in the volume and character of Swedish manufacturing sector innovation output between 1970 and 2007, a time span composed of both extended periods of relative prosperity and decline. More specifically, it examines whether changes in the number of innovations, the character of the innovating firms, and the distribution of innovations across industries are g
Research focus in environmental pollution has recently been extended from more classical environmental pollutants such as PCBs or pesticides to pharmaceuticals and steroid hormones, which are designed to be biologically active and enter the environment primarily through regular domestic use. Consequently, it is important to monitor these substances concentrations in the effluents of sewage treatme
BACKGROUND: This phase 3 study further characterizes the efficacy and safety of reslizumab (a humanized anti-interleukin-5 monoclonal antibody) in patients aged 12-75 years with asthma inadequately controlled by at least a medium-dose inhaled corticosteroid, and blood eosinophils ≥400cells/μL.METHODS: Patients were randomized to receive reslizumab 0.3 or 3.0mg/kg or placebo once/every 4 weeks/16 w
Human lactoferrin is an iron-binding glycoprotein that is particularly prominent in exocrine secretions and leukocytes and is also found in serum, especially during inflammation. It is able to sequester iron from microbes and has immunomodulatory functions, including inhibition of both complement activation and cytokine production. This study used mutants lacking pneumococcal surface protein A (Ps
Radiative transfer (RT) is a key component for investigating atmospheres of planetary bodies. With the 3D nature of exoplanet atmospheres being important in giving rise to their observable properties, accurate and fast 3D methods are required to be developed to meet future multidimensional and temporal data sets. We develop an open-source GPU RT code, gCMCRT, a Monte Carlo RT forward model for gen
Given a directed graph as input, we show how to efficiently find a shortest (directed, simple) cycle on an even number of vertices. As far as we know, no polynomial-time algorithm was previously known for this problem. In fact, finding any even cycle in a directed graph in polynomial time was open for more than two decades until Robertson, Seymour, and Thomas (Ann. of Math. (2) 1999) and, independ
ObjectivesThis article aims to find country-level factors that explain the rise of populist parties in European democracies. While populism is often connected to inequality, we not that right-wing populist parties tend to thrive on fear, including fear of job loss. If flexible labor markets mean that unemployment is dedramatized because finding a new job is easier, labor market flexibility could d
Accurate monitoring of the spatiotemporal variations in the gross primary productivity (GPP) in coastal wetlands is essential for blue carbon quantification. However, the currently available moderate-spatial-resolution GPP algorithms and products may contain large uncertainties and may rarely meet the demands of tidal wetland research. In this paper, we examine two statistical methods, namely, sim
Control based on image information offers great possibilities for advanced automation. Here, a flexible system for study of visual servoing has been developed by extending a standard computer with commercially available instrumentation. A robot moving on the floor is controlled by image feedback. The conclusion is that an industrially useful behavior of automated guided vehicles (AGV) in flexible
Since the 1990s, it has often been argued that the earth is like an island in space and that its brittleness is most clearly reflected on small islands in the oceans. Easter Island, for instance, with its largely depleted resources and an indigenous population which almost became extinct in the 19th century, has been seen as a microcosmic warning about what may happen to our entire planet. However
Dermatitis herpetiformis has been investigated in the past; however, only a limited number of studies have reported its incidence based on validated nationwide population-based registries. To address this gap, the aims of this study are to estimate the incidence of dermatitis herpetiformis in Sweden and to validate the National Patient Register (NPR) for diagnosis of dermatitis herpetiformis. A po
Background: Umbilical cord clamping strategies at preterm birth have the potential to affect important health outcomes. The aim of this study was to compare the effectiveness of deferred cord clamping, umbilical cord milking, and immediate cord clamping in reducing neonatal mortality and morbidity at preterm birth. Methods: We conducted a systematic review and individual participant data meta-anal
Background: Some endocrine disrupting chemicals (EDC), are “obesogens” and have been associated with overweight and obesity in children. Daily exposure to different classes of EDCs demands for research with mixtures approach. Objectives: This study evaluates the association, considering sex-specific effects, between prenatal exposure to EDC mixture and children's body fat at seven years of age. Me
