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Bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukaemia: updated results of a randomized phase III trial
The efficacy of bendamustine versus chlorambucil in a phase III trial of previously untreated patients with Binet stage B/C chronic lymphocytic leukaemia (CLL) was re-evaluated after a median observation time of 54months in May 2010. Overall survival (OS) was analysed for the first time. At follow-up, investigator-assessed complete response (CR) rate (21.0% vs 10.8%), median progression-free survi
Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations of IKZF1.
Supermacroporous poly(hydroxyethyl methacrylate) based cryogel with embedded bilirubin imprinted particles
Molecular imprinted polymers are artificial, template-made materials with the ability to recognize and to specifically bind the target molecule. The aim of this study is to prepare supermacroporous cryogel with embedded bilirubin-imprinted particles which can be used for the selective removal of bilirubin from human plasma. N-methacryloyl-(L)-tyrosinemethylester (MAT) was chosen as the pre-organiz
Deamidation and disulfide bridge formation in human calbindin D-2gk with effects on calcium binding
Calbindin D-28k (calbindin) is a cytoplasmic protein expressed in the central nervous system, which is implied in Ca2+ homeostasis and enzyme regulation. A combination of biochemical methods and mass spectrometry has been used to identify post-translational modifications of human calbindin. The protein was studied at 37 degrees C or 50 degrees C in the presence or absence of Ca2+. One deamidation
Coadsorption of Cu(II) and glyphosate at the water-goethite (alpha-FeOOH) interface: molecular structures from FTIR and EXAFS measurements
The coadsorption of Cu(II) and glyphosate (N-(phosphonomethyl)glycine, abbreviated to PMG) at the water-goethite interface was studied by means of batch adsorption experiments, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, and extended X-ray absorption fine structure (EXAFS) spectroscopy. The system was investigated over the pH range 3-9 and at total concentratio
Treatment with cyclosporin A during sensitization with trimellitic anhydride attenuates the airway responses to allergen challenge three weeks later
The present studies examined the effects of oral treatment with cyclosporin A, betamethasone or azelastine administered over the time of sensitization with trimellitic anhydride on allergen-induced airway responses, compared to those of control animals given corn oil alone. Drugs were given for 8 days. The animals were sensitized with trimellitic anhydride (0.1 ml of 0.3% w/v) in corn oil given in
Mycelial uptake, translocation and assimilation of nitrogen from N-15-labelled ammonium by Pinus sylvestris plants infected with 4 different ectomycorrhizal fungi
The uptake and assimilation of 15N-labelled ammonium was followed in Pinus sylvestris L. plants infected with four different ectomycorrhizal fungi, Rhizopogon roseolus Fr. Suillus bovinus (Fr.) O. Kuntze, Pisolithus tinctorius (Fr.) Fr. and Paxillus involutus (Mich. ex Pers.) Cohen & Couch. Plants were grown in flat perspex observation chambers or in Petri dishes containing non-sterile peat; i
Vitamin D receptor 3 ' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: The MrOS study in Sweden and Hong kong
The VDR is a prime candidate gene for osteoporosis. Here, we studied three common VDR haplotypes in relation to bone phenotypes in 5014 participants of the global MrOS Study. We also studied the relative expression of the haplotypes in human bone cells. One haplotype was associated with increased fracture risk and differently expressed in primary human bone cells. Introduction: Vitamin D plays an
Fe II emission spectra in AGN: observations and theoretical interpretation
The enrichment of Fe, relative to alpha elements such as O and Mg, represents a potential means to measure the ages of quasi-stellar object (QSO) host galaxies and probe nucleosynthesis in the early universe. QSOs exhibit prominent Fe II features and Mg II 2800 angstrom resonance doublet emission in the ultraviolet. Although chemical evolutionary models predict that the Fe/Mg abundance ratio decre
Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy
Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below the age of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorour
Ethics and vaccination
Background: Immunization programmes are ethically defensible and society has a significant role to play in providing vaccination against measles and safeguarding herd immunity to optimize its individuals' capabilities. Since preventive actions interfere with individuals who consider themselves as healthy, public health strategies - as distinct from advice in a clinical consultation - require somet
Synthesis of boronate-contaming copolymers of N,N-dimethylacrylamide, their interaction with poly(vinyl alcohol) and rheological behaviour of the gels
Cross-linking of polyvinylalcohol (PVA) by boronate-containing copolymer of N,N-dimethylacrylamide (DMAA, 1) was studied and compared to cross-linking of PVA by borate buffers in weakly alkaline solutions. The copolymer of M-w = 19,000 g mor(-1) containing 9 mol% N-acryloyl-m-aminophenylboronic acid (NAAPBA, 2) was prepared by free radical polymerization of the monomers, exhibiting copolymerizatio
Facilitation and interference among three predators affect their consumption of a stream-dwelling mayfly
1. We experimentally tested if a multiplicative risk model accurately predicted the consumption of a common mayfly at risk of predation from three predator species in New Zealand streams. Deviations between model predictions and experimental observations were interpreted as indicators of ecologically important interactions between predators. 2. The predators included a drift-feeding fish [brown t
(De)coding Modality : The Case of Must, May, Måste and Kan
This study investigates the mechanisms of (de)coding modality, focusing on the interpretation of utterances containing the modals must, may, måste, and kan. The main research question posed in this study is what enables the interlocutors to interpret modal expressions so that communicative goals are achieved. To answer this general question, Coates's (1983) study on modal contexts is initially rep
Optimal stopover decisions under wind influence: the effects of correlated winds
Wind speed and direction have a significant effect on a flying bird's ground speed. Migrants are therefore expected to be sensitive to wind conditions and this should have consequences for optimal strategies of stopover and refuelling. Based on an earlier model of time-minimizing migration which includes wind condition, we investigate the consequences of the temporal correlation of wind conditions
Effects of bioturbation on recruitment of algal cells from the "seed bank" of lake sediments
Effects of different bioturbators on recruitment of several nuisance algae, Anaboena spp. (Cyanophyta), Microcystis spp. (Cyanophyta), and Gonvostomum semen (Raphidophyta), from sediment to water were studied in a long-term laboratory experiment. Natural sediment, where macrofauna larger than 1 mm had been removed, was added to 18 aquaria. To each of six aquaria, individuals of Asellus aquaticus (
Dimerisation and an increase in active site aromatic groups as adaptations to high temperatures: X-ray solution scattering and substrate-bound crystal structures of Rhodothermus marinus endoglucanase Cel12A
Cellulose, a polysaccharide consisting of beta-1,4-linked glucose, is the major component of plant cell walls and consequently one of the most abundant biopolymers on earth. Carbohydrate polymers such as cellulose are molecules with vast diversity in structure and function, and a multiplicity of hydrolases operating in concert are required for depolymerisation. The bacterium Rhodothermus marinus,
Activity report 2019
SASNET Activity Report 2019 SWEDISH SOUTH ASIAN STUDIES NETWORK 2 SASNET ACTIVITY REPORT 2019 3SASNET ACTIVITY REPORT 2019 Table of Contents SASNET ACTIVITY REPORT 2019 5 SEMINARS AND PUBLIC EVENTS 6 WORKSHOPS AND CONFERENCES 8 Symposium on the Indo-Pacific in Singapore 8 South Asia across the Nordic Region (SANR) 2019 8 Workshop on Challenges to Media in South Asia 9 Workshop on Afghanistan: Migr
https://www.sasnet.lu.se/sites/sasnet.lu.se/files/activity_report_2019.pdf - 2026-05-08
Agrifood rapport 20172 impacts direct payments
Impacts of Direct Payments Lessons for CAP post-2020 from a quantitative analysis REPORT 2017:2 Mark Brady Jordan Hristov Sören Höjgård Torbjörn Jansson Helena Johansson Cecilia Larsson Ida Nordin Ewa Rabinowicz AgriFood Economics Centre Impacts of Direct Payments – Lessons for CAP post‐2020 from a quantitative analysis Mark Brady, Jordan Hristov, Sören Höjgård, Torbjörn Jansson, Helena J
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/agrifood_rapport_20172_impacts_direct_payments.pdf - 2026-05-08
