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Background How DNA repair enzymes find the relatively rare sites of damage is not known in great detail. Recent experiments and molecular data suggest that individual repair enzymes do not work independently of each other, but interact with each other through charges exchanged along the DNA. A damaged site in the DNA hinders this exchange. The hypothesis is that the charge exchange quickly libera
AIMS/HYPOTHESIS: Islet autoantibodies are important in diabetes classification and risk assessment, and as endpoints in observational studies. The Diabetes Autoantibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report results for glutamic acid decarboxylase autoantibodies (GADA) and islet antigen-2 autoantibodie
PURPOSE To evaluate the early treatment response in children with acute myeloid leukemia (AML) using a response-guided induction strategy that includes idarubicin in the first course. PATIENTS AND METHODS All Nordic children with AML younger than 15 years (n = 151) were treated on the Nordic Society for Pediatric Hematology and Oncology (NOPHO) AML 2004 protocol. After the first course of idarubic
Land use change from agricultural intensification has been highlighted as one of the major drivers of global declines in insects, reducing species diversity and abundance and shifting community composition towards generalist species. However, it remains a challenge to determine how land use change impacts the genetic diversity of species and populations even if this diversity is vital to their lon
We investigated the mRNA expression of G protein-coupled receptors (GPCRs) in cells from four human vascular beds: umbilical vein (HUVEC), microvasculature (MVEC), aorta (HAEC), and coronary artery (CAEC). Our study revealed that the orphan receptor ELTD1 (ADGRL4) was the most abundantly expressed GPCR mRNA in all four EC types. When recombinantly expressed in U87 cells, ELTD1 receptors activated
Swedish National Board of Housing, Building and Planning reported in "Energi i bebyggelsen"that 80 % of the detached houses in Sweden were under-ventilated, and had a flow of 0.23 l/(s·m2) on average instead of, by the code, required 0,35 l/(s·m2). Well known concerns here are lacking indoor environmental quality and a risk of moisture problems in certain rooms and in the envelope. The naturally v
Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. While limited anti-viral therapies exist, there is a paucity of direct therapies to directly attenuate viral pneumonia-induced lung injury, and management therefore remains largely supportive.
BackgroundThe optimal ways of using aromatase inhibitors or tamoxifen as endocrine treatment for early breast cancer remains uncertain.MethodsWe undertook meta-analyses of individual data on 31 920 postmenopausal women with oestrogen-receptor-positive early breast cancer in the randomised trials of 5 years of aromatase inhibitor versus 5 years of tamoxifen; of 5 years of aromatase inhibitor versus
In recent years, there has been a wave of opposition to feminism, gender equality, and minority rights in various national and international contexts. While there is a growing number of works that examine anti-gender campaigns, less attention has been devoted to the potential consequences of the anti-gender mobilizations for the internal relations within socially progressive (feminist and LGBTQ+) In recent years, there has been a wave of opposition to feminism, gender equality, and minority rights in various national and international contexts. While there is a growing number of works that examine anti-gender campaigns, less attention has been devoted to the potential consequences of the anti-gender mobilizations for the internal relations within socially progressive (feminist and LGBTQ+)
Light-chain (LC) monoclonal gammopathy of undetermined significance (MGUS) is a precursor of multiple myeloma (MM) and related conditions. LC-MGUS is characterized by free light-chain (FLC) levels outside defined reference intervals, indirectly indicating underlying plasma cell (PC) monoclonality. Next-generation flow cytometry (NGF) was used to evaluate clonal PC presence in bone marrow (BM) samp
BACKGROUND: Despite absence of level 1 evidence on the long-term oncological safety of non-operative management for rectal cancer (watch and wait), increased implementation has occurred globally over the past decades. In Sweden, a pan-national prospective non-randomized study was initiated in 2017 to assess its implementation.METHOD: Patients with biopsy-proven rectal cancer receiving neoadjuvant
Both the external oxidation of NADH and NADPH in intact potato (Solanum tuberosum L. cv. Bintje) tuber mitochondria and the rotenone-insensitive internal oxidation of NADPH by inside-out submitochondrial particles were dependent on Ca2+. The stimulation was not due to increased permeability of the inner mitochondrial membrane. Neither the membrane potential nor the latencies of NAD+-dependent and
To further clarify the mechanisms maintaining chronic atrial fibrillation (CAF), a method identifying preferable activation patterns of the atria during fibrillation, by time averaging of multiple discrete excitation vectors, was developed. Repeated recordings, each of 56 atrial bipolar electrograms simultaneously acquired during 8 s, were made at multiple sites in the right atrial free wall and t
In recent decades, the prognosis of Mantle Cell Lymphoma (MCL) has been significantly improved by intensified first-line regimens containing cytarabine, rituximab and consolidation with high-dose-therapy and autologous stem cell transplantation. One such strategy is the Nordic MCL2 regimen, developed by the Nordic Lymphoma Group. We here present the 15-year updated results of the Nordic MCL2 study
In order to obtain information on genes specifically expressed in the ectomycorrhizal symbiosis, 3,555 expressed sequence tags (ESTs) were analyzed from a cDNA library constructed from ectomycorrhiza formed between the basidiomycete Paxillus involutus and birch (Betula pendula). cDNA libraries from saprophytically growing fungus (3,964 ESTs) and from axenic plants (2,532 ESTs) were analyzed in par
Some large ecological studies have noted a significant association of testicular cancer (TC) with maternal smoking during pregnancy, while several more controlled studies have been negative. It has been difficult to obtain reliable data on exposure because of the long lag time to cancer diagnosis. We performed a case-control study nested within Finnish, Swedish and Icelandic maternity cohorts expl
Introduction: Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to estimate the annual person-level incidence for a wide spectrum of clinically diagnosed soft tissue knee injuries, and their distribution by age, sex, and season. Methods: In Sweden,
Tvister mellan arbetsgivare och arbetstagarparter är ett ständigt pågående fenomen och vilken parts mening som gäller till dess tvisten slutligt prövats är av betydelse och utgör denna uppsats frågeställningar. Den tillfälliga bestämmanderätten benämns tolkningsföreträde och uppsatsen syftar till att tydliggöra dess konstruktion, sanktionssystem, funktion och inverkan på arbetsledningsrätten. UtgåDisputes between employers and employee parties is a recurring phenomenon and which party´s opinion applies until the dispute is finally settled is of relevance and constitutes the purpose of this essay. The temporary authority of decision is known as preferential right of interpretation and this essay aims at clarifying its construction, sanctions, function and how it affects the employer´s manag
