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OBJECTIVE: Describe the clinical course and predictors of change in self-reported outcomes and objectively assessed physical function over time in middle-aged subjects at high risk of, or with knee osteoarthritis (OA). METHODS: We examined 259 subjects (mean age 52.6 [SD 10.4]) at mean 18 and 25 years after previous meniscectomy and 50 population-based age- and sex-matched reference subjects with

The new clusters [Ru-3(CO)(9)(mu-dppf){P(C4H3E)(3)}] (1, E = O; 2, E = S) have been prepared from the Me3NO-induced decarbonylation of [Ru-3(CO)(10)(mu-dppf)] in the presence of PFu(3) (E = O) and PTh3 (E = S), respectively. Upon thermolysis in benzene, the major products are the cyclometalated clusters [(mu-H) Ru-3(CO)(7)(mu-dppf){mu(3)-(C4H3E)(2)P(C4H2E)}] (3, E - O; 4, E - S). This thermolytic

The need to reduce CO2 emissions from fossil-fuel based power production creates the need for new power plant solutions where the CO2 is captured and stored or reused. Different concepts to capture CO2 fall into the three main categories: 1. Precombustion decarbonization 2. Oxy-fuel combustion 3. Post-combustion removal of carbon. In the first two types of processes Oxygen Transport Membrane (OTM)

Aim: To study the relationship between hyperglycaemia and the onset/progression of retinopathy, blindness/moderate visual impairment or death, as well as the impact of improved glycaemic control on retinopathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). Methods: Between January 1990 and October 1995 a total of 3,220 diabetic patients were enrolled in a programme for control

To present concept, methods and use of a knowledge database providing assessments of potential fetal risks for all drugs on the Swedish market. Assessments of fetal risks are made primarily by analyzing prospective epidemiological data from the Swedish Medical Birth Register on drug intake in relation to birth outcome. This is complemented by evaluation of the scientific literature. Following stan

Rising atmospheric carbon dioxide (CO2) may alleviate the toxicological impacts of concurrently rising tropospheric ozone (O-3) during the present century if higher CO2 is accompanied by lower stomatal conductance (g,), as assumed by many models. We investigated how elevated concentrations of CO2 and O-3, alone and in combination, affected the accumulated stomatal flux of O-3 (AFst) by canopies an

The presented study deals with the off-line coupling of preparative isotachophoresis (pITP) with on-line combination of capillary zone electrophoresis with electrospray mass spectrometric detection (CZE-ESI-MS) used for the analysis of therapeutic peptides (anserine, carnosine, and buserelin) in complex matrix (urine). Preparative capillary isotachophoresis, operating in a discontinuous fractionat

Despite the fact that large welfare states are vulnerable to free-riding, the idea that universal welfare states lead to higher trust levels in the population has received some attention and support among political scientists recently. This paper argues that the opposite direction of causality is more plausible, i.e. that populations with higher trust levels are more prone to creating and successf

The climate impact of new cars in Sweden 2009 has been evaluated by the Swedish Transport Administration. Their report takes into account reduction factors to attribute the positive impact of renewable fuels on CO2 emissions. The Swedish Transport Administration recommends the public to buy cars that can run on biofuels. Besides acknowledging prevailing uncertainties for many of the input paramete

Recent years molecular imprinting has received considerable attention as an excellent and simple approach to recognize small molecules and bioactive substances. The aim of this study is to prepare the bilirubin-imprinted supermacroporous cryogels which can be used for the adsorption of bilirubin from human plasma. N-methacryloyl(L)-tyrosinemethylester (MAT) was chosen as the preorganization monome

Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet a

BackgroundRetinal ischemia results in a progressive degeneration of neurons and a pathological activation of glial cells, resulting in vision loss. In the brain, progressive damage after ischemic insult has been correlated to neuroinflammatory processes involving microglia. Galectin-3 has been shown to mediate microglial responses to ischemic injury in the brain. Therefore, we wanted to explore th

Objectives To investigate the possible impact of maternal obesity on ultrasonographic dating of pregnancy. Methods The Swedish Medical Birth Registry was used to identify 842 083 singleton pregnancies for which the estimated date of deliver), (EDD) according to last menstrual period (EDD-LMP) and according to ultrasound examination (EDD-US) and maternal body mass index (BMI) in early pregnancy wer

Activated sludge model (ASM) is now widely used for wastewater treatment plant design, optimization and operation. Values for parameters to be used are vital for the accuracy of the modeling approach. This study aims to establish the scientific link between typical treatment and biodegradability of different chemical oxygen demand (COD) fractionation of palm oil mill effluent (POME), by means of r

Global concerns about climate changes and their association with the use of fossil fuels have accelerated research on biological fuel production. Biological hydrogen production from hemicellulose-containing waste is considered one of the promising avenues. A major economical issue for such a process, however, is the low substrate conversion efficiency. Interestingly, the extreme thermophilic bacte

We analyze a similar to 70 ks Chandra Advanced CCD Imaging Spectrometer exposure of the globular cluster omega Cen (NGC 5139). The similar to 17' x 17' field of view fully encompasses three core radii and almost twice the half-mass radius. We detect 180 sources to a limiting flux of similar to 4.3 x 10(-16) erg cm(-2) s(-1) (L-x = 1.2 x 10(30) erg s(-1) at 4.9 kpc). After accounting for the number

Hemoglobin is the major oxygen-carrying system of the blood, but has many potentially dangerous side effects due to oxidation and reduction reactions of the heme-bound iron and oxygen. Extracellular hemoglobin, resulting from hemolysis or exogenous infusion, is shown to be an important pathogenic factor in a growing number of diseases. This review briefly outlines the oxidative/reductive toxic rea

While only about 30% of California's usable water storage capacity lies at higher elevations, high-elevation (above 300 m) hydropower units generate, on average, 74% of California's in-state hydroelectricity. In general, high-elevation plants have small man-made reservoirs and rely mainly on snowpack. Their low built-in storage capacity is a concern with regard to climate warming. Snowmelt is expe

Benzimidazole units have been grafted onto a polysulfone (PSU) backbone via long alkyl thio–ether chains using a two-step procedure. In the first step, lithiated PSU was reacted with 10-undecenoyl chloride to graft PSU with undecenoyl side chains. The second step involved a free-radical thiol–ene coupling reaction between the C=C bonds of the pendant undecenoyl chains and 2-(2-benzimidazolyl)ethan