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BackgroundThe relationship between sleeping habits and aortic stiffness remains inconclusive and is not fully explored in the European general population.MethodsWe examined cross-sectionally 8659 participants from the Swedish population-based cohort Swedish CArdioPulmonary bioImage Study (SCAPIS), mean age 57.5 years, 52.1% women. A self-administered questionnaire on sleeping habits (duration, qua

Objectives To determine the incidence rate (IR) of myocardial infarction (MI), relative risk of MI, and impact of incident MI on mortality in individuals with biopsy-confirmed giant cell arteritis (GCA). Methods MIs in individuals diagnosed with GCA 1998-2016 in Skåne, Sweden were identified by searching the SWEDEHEART register, a record of all patients receiving care for MI in a coronary care uni

Purpose: The postponement principle concerns defining when and where value is added, usually referring to hardware components for physical products. However, in modern supply chains, software’s importance is increasing, impacting the timing and location of value-adding operations. Lacking insights into software-driven implications for postponement, we aim at elaborating on the postponement princip

New synthetic hybrid materials and their increasing complexity have placed growing demands on crystal growth for single-crystal X-ray diffraction analysis. Unfortunately, not all chemical systems are conducive to the isolation of single crystals for traditional characterization. Here, small-molecule serial femtosecond crystallography (smSFX) at atomic resolution (0.833 Å) is employed to characteri

Stimuli-responsive polymers stand out for their ability to respond to small environmental changes. One of the most representative thermo-sensitive materials is poly(N-isopropyl acrylamide) (PNIPAm), which presents reversible phase transitions close to the human body temperature. However, previous studies observed that the copolymerization of NIPAm with small quantities of different monomers like a

BACKGROUND: Sustained intrauterine hypoxia causes some four million perinatal deaths annually worldwide. The condition is predicated by neonatal acidemia, as determined by pH in umbilical cord blood at birth. We aimed to evaluate the association between umbilical cord arterial pH and long-term outcomes up to 20 years of follow-up.STUDY DESIGN: Using a retrospective cohort design, umbilical cord ar

X-ray free electron laser (XFEL) microcrystallography and synchrotron single-crystal crystallography are used to evaluate the role of organic substituent position on the optoelectronic properties of metal–organic chalcogenolates (MOChas). MOChas are crystalline 1D and 2D semiconducting hybrid materials that have varying optoelectronic properties depending on composition, topology, and structure. W

We develop a multiscale coarse-grain model of the NIST Monoclonal Antibody Reference Material 8671 (NISTmAb) to enable systematic computational investigations of high-concentration physical instabilities such as phase separation, clustering, and aggregation. Our multiscale coarse-graining strategy captures atomic-resolution interactions with a computational approach that is orders of magnitude mor

Introduction Despite the improvements in diabetes management by continuous glucose monitoring (CGM) it is difficult to capture the complexity of CGM data in one metric. We aimed to develop a clinically relevant multidimensional scoring model with the capacity to identify the most alarming CGM episodes and/or patients from a large cohort. Research design and methods Retrospective CGM data from 2017

We have studied the development of phospholipase A2 (PLA2) and lysophosphatidylcholine (lysoPC)-metabolising enzyme activities in the neonatal rat intestine and its relation to the intestinal permeability of macromolecules. The permeability was determined by feeding young rats a mixture of bovine serum albumin, bovine immunoglobulin G and fluorescein-isothiocyanate-conjugated dextran 70,000, and a

Background: Myocardial fibrosis, expressed as late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), is an important risk factor for malignant cardiac events in hypertrophic cardiomyopathy (HCM). However, CMR is not easily available, expensive, also needing intravenous access and contrast. Objective: To determine if derived vectorcardiographic spatial QRS-T angles, an aspec

Poor survival for breast cancer in low- and middle-income countries is largely attributed to late-stage diagnosis and limited access to diagnostic tools. Therefore, we propose using point-of-care ultrasound (POCUS) as a low-cost diagnostic solution paired with a deep learning (DL) model for cancer detection. While using DL has shown great potential, it is crucial to ensure the trustworthiness of a

BACKGROUND: Human diets account for 30% of greenhouse gas emissions (GHGE). Reporting dietary GHGE with or without energy standardization yields different outcomes, often resulting in conflicting conclusions regarding associations with micronutrient intake.OBJECTIVES: To compare methods of reporting dietary GHGE, with and without consideration of energy intake, and their respective associations wi

During the Secret War in Laos, 1964-1973, the United States dropped approximately 2 million tons of bombs in Laos. However, 30% of the employed bombs failed to detonate. It is estimated that 78 million unexploded ordance (UXO) still contaminate the land of Laos. This paper therefore aims to explore how UXO affect the possibilities for the rural population in Houamoung district to attain a sustaina

Syftet med denna studie är att ur ett sociologiskt perspektiv undersöka hur det är att bo i Barcelona och arbeta i ett internationellt callcenter som ung europeisk medborgare. Vad är det som motiverar individer att migrera och arbeta i Barcelona? Hur upplever de förutsättningar i arbetet, social gemenskap och hur uppfattar de sin tillhörighet? Dessa frågeställningar sätts sedan i en bredare kontexThe aim of this study is from a sociological perspective understand how it is to live in Barcelona while working in an international call centre as a young European citizen. What motivates these individuals to migrate to Barcelona? What is their perspective of work, social community and notion of belonging? These questions are later to be examined together with theories of migration, modernization

Prisons encourage criminal activity and have negative impacts on sentenced individuals according to studies. Meanwhile the three largest political parties in Sweden work towards implementing tougher sentences. The three largest parties have in common their position on law enforcement which disputes what the research is saying and as a consequence, the objective of achieving less criminal activity

Behövs kemiska bekämpningsmedel inom jordbruket? I Sverige finns ekologiska jordbruk, detta betyder bland annat att kemiska bekämpningsmedel inte används för att bespruta grödorna inom dessa jordbruk. Ekologiska lantbrukare använder sig istället av biologisk kontroll, vilket betyder att naturliga rovdjur till skadeinsekter introduceras i jordbrukslandskapet för att äta skadeinsekterna. För att unChemical pesticides have long been used to keep crops free from pests, but in modern agriculture biological control is viewed as a viable alternative to pesticides. The concept of biological control is to implement predators that feed upon the pests. It can however be difficult to follow the effects of the biological control in the field, which is why a theoretical mathematical model has been desi

A simpler version of a shock-testing machine was developed and built. This allows engineers at Verisure to test prototypes and early versions of new products before the product is certified. An independent company shock tests the product as part of the process to certify it as an approved home alarm security product. During the shock test, the product is subjected to a high acceleration during a s

I januari 2008 trädde två nya lagar ikraft i Sverige. Lagen (2007:978) om hemlig rumsavlyssning gav de brottsbekämpande myndigheterna rätten att använda en ny metod, rumsavlyssning för att utreda redan begångna brott och lagen (2007:979) om åtgärder för att förhindra vissa särskilt allvarliga brott introducerade en möjlighet för myndigheterna att använda hemliga tvångsmedel som teleavlyssning, telIn January 2008 two new legislations entered into force in Sweden. The law (2007:978) on bugging gave the crime fighting authorities the right to use a new method, bugging, to investigate already committed crimes and the law (2007:979) on measures to prevent particularly serious crimes introduced a possibility for the authorities to use secret surveillance as telephone tapping, wire monitoring, fi

Of increasing interest in the field of protein modelling and simulation is the effects of crowding. In a living cell, large molecules can take up 30% of the cell plasma volume, and affects the folding and dynamics of proteins. Computer simulations have so far focused mainly on simple spherical crowders, but recent simulations with protein crowders have shown effects beyond what can be replicated u