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Insulin resistance causes compensatory insulin production, which in humans can eventually progress to β-cell failure and type 2 diabetes (T2D). This disease progression involves multi-scale processes, ranging from intracellular signaling to organ and whole-body level regulations, on timescales from minutes to years. T2D progression is commonly studied using overfed and genetically modified rodents

Background: Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposited in the respiratory tract. Knowledge of the underlying mechanisms behind observed symptoms is still partly lacking, although inflammation is suggested to play a central role. Th

The road safety barriers are today designed and installed in compliance with the European standards for Road Restraint Systems (EN 1317), which lays down common requirements for the testing and certification in all EU countries. The introduction of the European Union (EU) regulation for safety barriers, which is based on performance, has encouraged European road agencies to perform an upgrade of t

Objective: The objective of this study was to compare short-term outcomes in patients who underwent thoracic endovascular aortic repair (TEVAR) with stent grafts alone or with a composite device design (stent graft plus bare-metal aortic stent) for acute type B aortic dissection in the setting of malperfusion. Methods: This retrospective analysis included patients with acute (≤14 days of symptom o

Purpose – The purpose of this paper is to increase understanding of the use of standards and modularity for improving responsiveness in the humanitarian context. Design/methodology/approach – Based on a conceptual framework and a systematic literature review, the authors conducted a longitudinal, explorative case on the Emergency Response Unit (ERU) concept in the International Federation of Red C

AIMS: There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology.METHODS: We conducted a 2-round, 33-question, web-based Delphi survey on perioperative management (preoperative work-up, surgical procedure

PURPOSE: To evaluate clinical practice in the diagnosis and treatment of progressive keratoconus with corneal crosslinking (CXL) in four Nordic countries.METHODS: A questionnaire was sent to all centres at which keratoconus patients are evaluated and CXL is performed in Sweden, Denmark, Norway and Iceland. Nineteen of 20 centres participated.RESULTS: CXL is performed approximately 1300 times per y

Clofarabine has been shown to effectively induce remission in children with refractory leukemia. We conducted a prospective trial (clinicval.trials.gov NCT01025778) to explore the use of clofarabine-based chemotherapy as a bridge-to-transplant approach. Children with refractory acute leukemia were enrolled to receive two induction courses of clofarabine, etoposide, and cyclophosphamide (CloEC). Re

We compute strain distributions in core-shell nanowires of zinc blende structure. We use both continuum elasticity theory and an atomistic model, and consider both finite and infinite wires. The atomistic valence force-field (VFF) model has only few assumptions. But it is less computationally efficient than the finite-element (FE) continuum elasticity model. The generic properties of the strain di

Objectives To study the effect of insulin treatment in combination with metformin or an insulin secretagogue, repaglinide, on glycaemic regulation in non-obese patients with type 2 diabetes. Design Randomised, double blind, double dummy, parallel trial. Setting Secondary care in Denmark between 2003 and 2006. Participants Non-obese patients (BMI <= 27) with preserved beta cell function. Interventi

PLC-system (Programmable Logic Controller) är robusta realtidssystem som används för att styra fysiska processer i krävande miljöer. Moderna PLC-system är väldigt kapabla, men skulle systemet mot förmodan gå på knä, kan man alltid installera ännu ett PLC-system i mån av plats. En lyx som inte finns ombord på ubåtar, där man istället behöver hushålla med befintliga system. Med hjälp av två matematiThis master’s thesis is commissioned by SAAB Group with the purpose of developing a model which can be used to estimate the margin for expansion of devices in PLC systems. Although commercial PLC systems are hard real-time systems, they have inherited unpredictable characteristics due to off-the-shelves components. This makes it difficult to measure the impact on performance when a new device is c

Rennet coagulation ability of milk is of utmost importance in cheese manufacturing industry since it is directly related to cheese quality and yield, then translated into economic benefit. This study examined the rennet coagulation ability and composition of milk from individual Swedish Red (SR) cows, the second most common dairy breed in Sweden. Additionally, the study explored how the presence o

Abstract: The food consumption of today’s world has led to an overconsumption of the earth resources. It is easy to forget that when we consume we do not only consume a product we are also consuming other peoples labour and landscapes in, many times, far off places. With daily news on environmental damages, people are becoming more aware. Consequently, people are getting more interested in the ori

Hållbar stadsutveckling är ett viktigt och allt mer prioriterat fokus inom samhällsplanering. Inom ramen för detta har gröna lösningar (ny eller upprustad grönyta, så som parker, gröna stråk, och regnträdgårdar) på senare tid fått ökad uppmärksamhet. Grönska och naturmiljöer utgör viktiga inslag i stadsmiljön och bidrar till att göra den täta staden trivsam, levnadskraftig och attraktiv, samtidigtIn the realm of urban planning, urban greening – the creation or restoration of green spaces in cities – has risen as an attractive approach for policy-makers and planners engaged in sustainability. As the benefits of urban greening are many, from social and cultural to environmental and economic, it has become positioned as a win-win solution to several urban challenges related to sustainable dev

Denna uppsats undersöker hur fem icke-statliga organisationer (NGO) framställer händelserna kring Sea-Watch 3-fallet sommaren 2019. Räddningsfartyget hölls kvar till havs i över två veckor efter att ha undsatt migranter utanför Libyens kust, utan att någon stat erbjöd en säker hamn. Studien utgår från en kombination av två teoretiska ramverk: normmodellen och liminalitet. Normmodellen används för This thesis examines how five non govermental organisations (NGO) represent the events surrounding the Sea-Watch 3 case in the summer of 2019. The rescue vessel remained at sea for over two weeks after saving migrants off the coast of Libya, without any state offering a safe port of disembarkation. The study draws on a combination of two theoretical frameworks, the norm model and liminality. The n

This study presents a transformative advancement in water-energy nexus management by developing a hydrostatic pressure wheel (HPW) system that simultaneously optimizes water level regulation and hydropower generation in open-channel irrigation systems (OCISs)—a dual functionality not achieved by existing technologies. While conventional waterwheels focus solely on energy production, our HPW design

Objective: Drug-coated balloons (DCB) might improve the results of below the knee (BTK) angioplasty, but sufficient randomized data comparing DCB and conventional angioplasty in treating patients with chronic limb threatening ischemia (CLTI) are lacking. This study aimed to perform a randomized comparison between a paclitaxel-coated angioplasty balloon catheter and a conventional balloon angioplas

More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), the most important factor for directing anti-estrogenic endocrine therapy (ET). Recently, mutations in ESR1 were identified as acquired mechanisms of resistance to ET, found in 12% to 55% of metastatic breast cancers treated previously with ET. We analyzed 3217 population-bas

4MOST,1 the 4m Multi-Object spectrographic Survey Telescope, is an upcoming optical, fiber-fed, MOS facility for the VISTA telescope at ESO's Cero Paranal Observatory (Chile). The preliminary design of 4MOST features 2,400 fibers split into a low-resolution (1,600 fibers, 390-900 nm, R > 5; 000) and a high-resolution channel (800 fibers, three arms, ∼20-25 nm coverage each, R > 18; 000) with an Ec

Introduction: Monoaminergic activity modulates nociceptive transmission in the central nervous system (CNS). Although pain is the most disabling symptom of osteoarthritis (OA), limited knowledge exists regarding the CNS mechanisms that amplify pain and drive sensitization processes in humans.Objectives:The main objective of this study was to evaluate associations between cerebrospinal fluid (CSF)