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Large-Eddy Simulations of Thermal Ribbed Duct Flows

Ribbed channel flows are encountered in numerous engineering applications to promote turbulence and enhance heat transfer in various cooling passages, e.g., in turbine blades and at combustor walls. Numerical simulations have become an increasingly useful tool for providing insights into complex turbulence and flow separation, which are critical to the design and optimization of such channels. In

How are children's best interests expressed during their hospital visit?-An observational study

Aims and objectives: To describe ways in which children's best interests were observed to be expressed in paediatric settings during their hospital visit.Background: The best interests of the child are embodied in national and international legal systems, although the definition remains problematic. The child's limited autonomy mandates duty bearers to have both a child perspective and the child's

Proposing "sustainable meetings" : international convention bureaus positionings in the post covid time

Proposing “sustainable meetings”: convention bureaus marketing of destinations as ethicalIn the wake of a crisis and restrictions on physical interactions, the importance of meetings is emphasized more than ever. The meetings industry has gone from unprecedented down-sizing to higher booking rates than ever, and attracting meetings is an important part of municipalities place brandingstrategies. A

Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases

OBJECTIVE: Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory myopathies (myositis) are complex conditions characterized by shared circulating autoantibodies and clinical manifestations, including skin rashes, among others. This study was aimed at elucidating the genetics underlying these common f

Nationwide observational study of incidence, management and outcome of spontaneous coronary artery dissection : a report from the Swedish Coronary Angiography and Angioplasty register

Objectives The aim of this study was to conduct a nationwide all comer description of incidence, contemporary management and outcome in Swedish spontaneous coronary artery dissection (SCAD) patients. The incidence of SCAD as well as the management and outcome of these patients is not well described. Design A nationwide observational study. Participants and setting All patients with SCAD registered

Kinetics of human soluble and membrane-bound catechol O- methyltransferase : A revised mechanism and description of the thermolabile variant of the enzyme

Human soluble (S) and membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1.1.6) enzymes have been expressed at sufficiently high levels in Escherichia coil and in baculovirus-infected insect cells to allow kinetic characterization of the enzyme forms. The use of tight-binding inhibitors such as entacapone enabled the estimation of actual enzyme concentrations and, thereby, comparison of

On the dosimetric behaviour of photon dose calculation algorithms in the presence of simple geometric heterogeneities: comparison with Monte Carlo calculations

A comparative study was performed to reveal differences and relative figures of merit of seven different calculation algorithms for photon beams when applied to inhomogeneous media. The following algorithms were investigated: Varian Eclipse: the anisotropic analytical algorithm, and the pencil beam with modified Batho correction; Nucletron Helax-TMS: the collapsed cone and the pencil beam with equ

Antikorruptionsförebyggande tredjepartsbesiktning och GDPR

Tredjepartsbesiktning innebär att blivande eller befintliga affärspartners undersöks i syfte att säkerställa att verksamhetsutövarens verksamhetsled utgör en låg risk för korruption, vilket i vissa länder krävs genom lag. Faktorer som i regel anses som varningsflaggor i riskbedömningen inför en affärstransaktion är till exempel om en affärspartner har dömts för något brott av korruptiv karaktär elThird party due diligence is an investigation of prospective or existing business partners in order to ensure a low risk of corruption. In certain countries such an investigation is required by law. Factors to consider in the risk assessment are for example whether a potential or existing business partner has been convicted of any corruption related crime or is associated with political circles. S

Regulation of HPV16 splice sites located in the E6/E7 oncogene coding region

Kan cellers proteiner bota HPV- sjukdomar? Livmoderhalscancer är en av de vanligaste cancersjukdomarna som drabbar kvinnor världen över. Varje år, diagnostiseras ungefär 500 000 kvinnor och 270 000 dör i sjukdomen, varav de flesta dödsfallen sker i utvecklingsländer. Livmoderhalscancer orsakas av det vanligt förekommande viruset humant papillomvirus (HPV) och för att hitta bättre behandling mot sHuman papillomaviruses (HPVs) are small DNA viruses that have evolved over millions of years and are well-adapted to humans. Persistent infections with HPVs, can result in cancer development. There are over 200 different HPV types that can be divided into high- and low risk types based on their ability to cause cancer. HPV16 is the most common high- risk type that accounts for more than 50 % of al

Wisdom in absence of a crowd

Purpose: The purpose of this study is to investigate what factors, if any, are most prevalent in the valuation of small cap stocks, with limited ownership as compared to their fundamental values, where crowd based trading and insights do not necessarily prevail. Methodology: A deductive and comparative study realized in quantitative research based upon a sample selection of smaller companies. Find

Dynamic Mapping of Diesel Engine through System identification

From a control design point of view, modern diesel engines are dynamic, nonlinear, MIMO systems. This paper presents a method to find low-complexity black-box dynamic models suitable for model predictive control (MPC) of NOx and soot emissions based on on-line emissions measurements. A four-input-five-output representation of the engine is considered, with fuel injection timing, fuel injection dur

Genes involved in muscle contractility and nutrient signaling pathways within celiac disease risk loci show differential mRNA expression

Background: Risk gene variants for celiac disease, identified in genome-wide linkage and association studies, might influence molecular pathways important for disease development. The aim was to examine expression levels of potential risk genes close to these variants in the small intestine and peripheral blood and also to test if the non-coding variants affect nearby gene expression levels in chi

Soil surface CO2 efflux measurements in Norway spruce forests: Comparison between four different sites across Europe - from boreal to alpine forest

Extensive measurements of soil surface (including vegetation cover) CO2 efflux were carried out on 80 positions at four different forest sites (Sweden, Germany, Czech Republic and Italy) using a closed dynamic chamber technique. The period of measurement was 4-5 consecutive days per site. Two approaches were used to analyze the measured data, the Q(10) parameter and the Arrhenius relationship. Bas

Turbulence Modelling and Parallel Solver Development Relevant for Investigation of Gas Turbine Cooling Processes

To enhance the performance of gas turbine engines, high top-cycle temperatures are desired. However, the temperature is limited by current materials. To achieve the higher performance, and meanwhile maintain the metal temperatures of the combustors, vanes and blades below the allowable limits, sophisticated cooling techniques, such as impingement cooling, film cooling and convective internal cooli

Copy number variants in the kallikrein gene cluster.

The kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases. We searched for copy number variants in all KLK genes using quantitative PCR analysis and analysis of inheritance patterns of single nucleotide polymorphisms. Two deletions were identified: one 2235-bp deletion

Importance of healthcare utilization and multimorbidity level in choosing a primary care provider in Sweden.

Abstract Objective. To study the associations between active choice of primary care provider and healthcare utilization, multimorbidity, age, and sex, comparing data from primary care and all healthcare in a Swedish population. Design. Descriptive cross-sectional study using descriptive analyses including t-test, correlations, and logistic regression modelling in four separate models. Setting and

On observation distributions for state space models of population survey data.

1. State space models are starting to replace more simple time series models in analyses of temporal dynamics of populations that are not perfectly censused. By simultaneously modelling both the dynamics and the observations, consistent estimates of population dynamical parameters may be obtained. For many data sets, the distribution of observation errors is unknown and error models typically chos