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AbstractPURPOSE: To assess the relative influence of genetic and environmental factors on optic disc size and cup/disc ratio in healthy eyes. METHODS: A sample of 55 monozygotic and 50 dizygotic healthy twin pairs aged 20-46, all having the same sex within pairs (47 pairs were male) had optic discs measured from colour fundus photographs according to the Wisconsin Protocol. Structural equation mod
This paper discusses methods to test the performance of the adaptation layer in a self-adaptive system. The problem is notoriously hard, due to the high degree of uncertainty and variability inherent in an adaptive software application. In particular, providing any type of formal guarantee for this problem is extremely difficult. In this paper we propose the use of a rigorous probabilistic approac
We characterised patients with mantle cell lymphoma (MCL) with poor prognosis based on differences in immune infiltration. Different expressions of the tumour cell markers Cyclin D1 and sex-determining region Y-box transcription factor 11 (SOX11), and the immune markers cluster of differentiation 3 (CD3), CD4, CD8, CD25, forkhead box protein P3 (FoxP3), T-box transcription factor TBX21 (T-bet), pr
Previous studies have suggested that the development of diabetes in the BB rats does not require the expression of T lymphopenia. In order to derive non-lymphopenic diabetic rats and define the relationship between the T cell abnormalities, MHC genotype, and diabetes, we performed a cross between BB/H and diabetes resistant BB/control followed by an intercross of the F1. In the F2, the overall inc
Solar energy is an important source of clean energy to combat climate change issues that motivate the establishment of solar farms. Establishing solar farms has been considered a proper alternative for energy production in countries like Mozambique, which need reliable and clean sources of energy for sustainable development. However, selecting proper sites for creating solar farms is a function of
Basal cell carcinoma (BCC) is a common skin cancer type and affected individuals are known to be at risk of developing multiple consecutive tumours. Research into BCC multiplicity has, thus far, been challenging, due to a lack of national registration. This registry-based cohort study aimed to analyse the occurrence of multiple BCCs in Sweden, and risk factors for subsequent primary BCCs. Data reg
Effects of pilot H2 injection on the thermoacoustic instability of premixed CH4/air flames were experimentally investigated with varied hydrogen injection rates and different injection strategies. The flames were stabilized on a swirl burner with a central pilot-fuel injection tube. The flame structure was captured using high-speed OH* chemiluminescence and OH-PLIF methods, while the CO and NOx em
Around the world today, universities are expected to play a unique role as creators of regional growth and innovation. While there appears to be a consensus that the role of universities has been expanded, critiques show that the contribution of universities to their regions is still not well defined. There have been some developments in the literature on the concept of modern universities such as
Background: To examine rates of serious pneumococcal infections up to 10 years after vaccination with 7-valent conjugated pneumococcal vaccine (PCV7) in patients with arthritis compared to non-vaccinated arthritis patients.Methods: In total, 595 adult arthritis patients (rheumatoid arthritis; RA = 342, 80 % women and spondylarthropathy; SpA = 253, 45 % women) received one dose of PCV7. Mean age/di
Automated soil moisture systems are commonly used in precision agriculture. Using low-cost sensors, the spatial extension can be maximized, but the accuracy might be reduced. In this paper, we address the trade-off between cost and accuracy comparing low-cost and commercial soil moisture sensors. The analysis is based on the capacitive sensor SKU:SEN0193 tested under lab and field conditions. In a
Background: Hyperuricemia (HU) is in the causal pathway for developing clinical gout. There are few population-based assessments of the absolute and relative risk of clinically diagnosed incident gout in subjects with HU. We aimed to explore the long-term risk of developing incident gout among asymptomatic adults with different levels of serum urate (SU). Methods: Malmö Preventive Project was a po
Remote homology detection among proteins utilizing only the unlabelled sequences is a central problem in comparative genomics. The existing cluster kernel methods based on neighborhoods and profiles and the Markov clustering algorithms are currently the most popular methods for protein family recognition. The deviation from random walks with inflation or dependency on hard threshold in similarity
Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled
Purpose: The research community has focused on defining reliable biomarkers for the early detection of the pathological hallmarks of Alzheimer’s disease (AD). In 2017, the Geneva AD Biomarker Roadmap initiative adapted the framework for the systematic validation of oncological biomarkers to AD, with the aim to accelerate their development and implementation in clinical practice. The aim of this wo
Aims. We study the dynamics and growth of dust particles in circumstellar disks of different masses that are prone to gravitational instability during the critical first Myr of their evolution. Methods. We solved the hydrodynamics equations for a self-gravitating and viscous circumstellar disk in a thin-disk limit using the FEOSAD numerical hydrodynamics code. The dust component is made up of two
We report on the detection of a remarkable new fast high-energy transient found in the Chandra Deep Field-South, robustly associated with a faint (mR = 27.5mag, zph ~2.2) host in the CANDELS survey. The X-ray event is comprised of 115+12 -11 net 0.3-7.0 keV counts, with a light curve characterized by an ~100 s rise time, a peak 0.3-10 keV flux of ~5 × 10-12 erg s-1 cm-2 and a power-law decay time
PurposeTo present baseline characteristics and to present the perioperative corneal thickness during corneal crosslinking (CXL) treatment for progressive keratoconus and to describe how the addition of sterile water (SW) efficaciously can maintain the corneal thickness. The treatment efficacy will be evaluated when the 1-year follow-up is complete.MethodsA randomised clinical study using epitheliu
We propose drl-RPN, a deep reinforcement learning-based visual recognition model consisting of a sequential region proposal network (RPN) and an object detector. In contrast to typical RPNs, where candidate object regions (RoIs) are selected greedily via class-agnostic NMS, drl-RPN optimizes an objective closer to the final detection task. This is achieved by replacing the greedy RoI selection pro
Global gene expression analysis has been a major tool for urothelial carcinoma subtype discovery. This approach has revealed extensive complexity both in intrinsic features of the tumor cells and in the microenvironment. However, global gene expression cannot distinguish between gene expression signals originating from the tumor cells proper and from normal cells in the biopsy. Here, we use a larg
Background and purpose — With a rapidly increasing population in need of total knee arthroplasty (TKA), there is renewed interest in cost-saving all-polyethylene designs. Differences between metal-backed and all-polyethylene designs in initial component migration assessed by radiostereometric analysis (RSA), a proven predictor for late aseptic loosening, have been scantily reported. The purpose of
