Sökresultat

Epigenetic code modifications by histone deacetylase inhibitors (HDACis) have recently been proposed as potential new therapies for hematological malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common form of aggressive lymphoma. At present, standard first line treatment for DLBCL patients is the antracycline-based chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristi

In today’s society more and more work is carried out with the help of dif- ferent computer systems. To benefit from the data, integration between the systems is needed. Saab has developed a solution to the problem, by the name WISE. With a modular design costs can be minimized, because a new integration does not necessarily require new software, but can be achieved with configuration of an existin

Detta examensarbete rör direktiv 2006/46/EG och dess överensstämmelse med den europeiska konventionen om skydd för de mänskliga rättigheterna och de grundläggande friheterna. Examensarbetet använder Sverige som ett exempel, och analyserar främst lagen (2003:389) om elektronisk kommunikation och dess tillkortakommanden vad gäller brottsbekämpande myndigheters tillgång till lagrade trafikuppgifter. This thesis concerns Directive 2006/46/EC and its compliance with the European Convention on Human Rights and Fundamental Freedoms. The thesis uses Sweden as an example, and mainly analyses the shortcomings in Swedish legislation on how traffic data may be accessed by law enforcement authorities, finding that the regulations under the Swedish Electronic Communications Act breaches Article 8 and 13

Studies of dog assisted interventions often focus on the effects they have on clients health or situation. In contrast, the aim of this study was to analyze supervisors descriptions of dog assisted interventions in daily activity centers and to discuss how these interventions might affect the client’s situation. The study was performed through six semi-structured interviews using a thematic interv

Provokation som grund för strafflindring regleras i 29 kap. 3 § första stycket 1 BrB och då domstolen anser att någon objektivt sett har blivit utsatt för ett uppenbart kränkande beteende kan detta få verkan i förmildrande riktning i påföljdsbestämningen. Domstolar har ett relativt stort utrymme att fastställa vad som kan utgöra provokation på grund av att det finns få uttalanden i förarbeten och Provocation as a basis for mitigation of a sentence is regulated in Chapter 29. 3 § first paragraph 1 of the Penal Code and this can have effect in mitigating direction when the court considers that someone has been a victim of a clearly degrading behavior from an objective point of view. Courts have a relatively broad discretion to determine what may constitute provocation because there are only

Introduction: Depression is frequent in ankylosing spondylitis (AS) patients. However, epidemiological data about the potential increase in risk are lacking. This study compares the rate of doctor-diagnosed depression in a well defined cohort of AS patients to the general population seeking care. Methods: The Skane Healthcare Register comprises healthcare data of each resident in Region Skane, Swe

Premixed turbulent flame-based technologies are rapidly growing in importance, with applications to modern clean combustion devices for both power generation and aeropropulsion. However, the gain in decreasing harmful emissions might be canceled by rising combustion instabilities. Unwanted unsteady flame phenomena that might even destroy the whole device have been widely reported and are subject t

Psykiskt störda lagöverträdare har länge särbehandlats i den svenska rättsordningen. I nästan alla rättssystem ingår ett krav på tillräknelighet som brottsförutsättning. Detta krav togs bort i den svenska straffrätten i samband med brottsbalkens ikraftträdande 1965. Att vara tillräknelig innebär att man har en viss förmåga att förstå vad man gör, och att man kan kontrollera sitt handlande. Endast Mentally disturbed offenders have for a long time been treated differently in the Swedish criminal law. In nearly all legal systems there is a requirement of accountability for criminal liability. In order to be accountable you have to possess the ability to understand your actions and to be able to control them. Only then you can be punished for a criminal act. The requirement was removed from th

The research field of middle management within elderly care in Sweden is fairly unexplored. Even more so, there is little to no research on communication or communicative leadership and its influence on middle management within elderly care. Therefore, this study aims to investigate managers perspective on communication by interviewing middle managers working with elderly care. Furthermore, the st

During the past few years the focus on bioprocess monitoring and control has increased. An area still under intensive development is the sampling methods for efficient and rapid analysis during fermentations. In this thesis, an online-sampling and monitoring scheme was developed using the versatile automated continuous flow system (VersAFlo) for recombinant protein production. From the implementat

Identifying and keeping track of different structural representations of functionally overlapping issues is important in order to keep a well maintained issue management corpus, establishing efficient and organized response ability to develop and code software patches repairing these issues and defects. This is normally achieved by manual, time-costly reviewing-processes by special teams put up to

Förskolorna måste göra mer på hälsoskyddsområdet än att lära barn tvätta händerna Samtliga förskolor i Lomma Kommun har under 2012 och 2013 inspekterats av miljökontoret för att följa upp Socialstyrelsens projekt om hygien och smittskydd i förskolan från 2009. Resultatet visar att de 24 förskolorna i Lomma Kommun har bra rutiner för hygien, smittskydd och städning. Andra områden som krävs enligStudies have showed that children that are spending their daytime at preschools suffer from more infections than children who stay at home. The indoor environment has a big impact on our health and therefore it must be good and suitable for the children in preschools. According to the Swedish environmental laws preschools must set- up preventive work to avoid environmental and health problems an

Varje år kommer ett stort antal barn och ungdomar i skolålder till Sverige. De har alla rätt till utbildning enligt Skollagen och Barnkonventionen. Många av dem börjar sin skolgång i förberedelseklasser eller på Språkintroduktionsprogram. Syftet med den här uppsatsen är att skapa förståelse för den betydelse dessa har för uppfyllandet av rätten till utbildning för nyanlända elever. I studien använEvery year a large number of children and youths of school-age immigrate to Sweden. They all have the right to education according to the Swedish education act and the Convention of the Rights of the Child. Many of them begin their schooling in preparatory classes or the gymnasium program "Språkintroduktion" (language introduction). The aim of this essay is to create an understanding of

Fabriksrevision används som ett verktyg för att kontrollera att leverantörer och underleverantörer uppfyller kraven i kontraktsvillkor och det är ett steg i uppföljningsprocessen. I decennier har det rapporterats om arbetsrättsliga- och människorättsliga kränkningar i globala leveranskedjor där fabriksrevision används som en mekanism för att säkerställa goda arbetsvillkor. Dock kritiseras fabriksrSocial audits are used as a tool for performing reviews on suppliers’ and sub-suppliers’ compliance towards contractual obligations and is a step in the review process. There have been reports of violation of labor- and human rights laws in the global supply chains where social audits are put in place to secure good working conditions. Business segments have been criticized to have failed on their

Att man blir trött och hängig av värme känner nog de flesta till, men de flesta av oss klarar det tack vare skugga, solskydd och vätska. Men under en intensiv och långvarig värmebölja kan det bli riktigt allvarligt om du är äldre och samtidigt har en i övrigt vacklande hälsa. Under senare år och inte minst under den senaste värmeböljan sommaren 2018 insåg många verksamhetsutövare för vård-/äldreboIn recent years, heat waves have begun to be perceived as one of the biggest problems due to climate change. The Public Health Agency, which is the national supervisory guidance regarding health effects, has therefore updated its guidelines to ensure that regions and municipalities have sufficient information to carry out inspections in accordance with the Environmental Code. This study focuses

Society relies on the continued operation of software systems, from healthcare to social media platforms. These systems can be engineered to be highly reliable, but complexity assures surprise. People have the ability to manage this complexity, filling gaps in design by recognizing, diagnosing and correcting anomalies. Rarely can surprises be managed by individuals alone. When engaged in anomaly r

An extensive variety of THAP1 sequence variants have been associated with focal, segmental and generalized dystonia with age of onset ranging from 3 to over 60 years. In previous work, we screened 1114 subjects with mainly adult-onset primary dystonia (Neurology 2010; 74:229-238) and identified 6 missense mutations in THAP1. For this report, we screened 750 additional subjects for mutations in cod

Reduction of energy use in buildings is an important measure to achieve climate change mitigation. It is essential to minimize heat losses when designing and building energy efficient buildings. For an energy-efficient building in a cold climate, a large part of the space heating demand is caused by transmission losses through the building envelope. Therefore, calculations of these must be carried

We describe a NOVel form of Adaptive softening (NOVA) for collisionless N-body simulations, implemented in the RAMSES adaptive mesh refinement code. In RAMSES - that we refer to as a 'standard N-body method' - cells are only split if they containmore than eight particles (amass refinement criterion). Here, we introduce an additional criterion that the particle distribution within each cell be suff