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Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen fibrils in vitro. We have examined whether such mAbs have detrimental effects on pre-existing cartilage. Bovine cartilage explants were cultured over 21 days in the presence of two arthritogenic mAbs to

This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples. This strategy involves using antibodies circulating in plasma to affinity-enrich antigenic proteins in biochemically fractionated pools of bacterial proteins, followed by their identification and quantification using mass spe

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

We describe a simple, yet practical and precise. way of measuring sorption isotherms with each sample in its own glass jar with a saturated salt solution. The measurements are done with below-balance weighing and with the sample kept inside the closed jar during the whole measurement period, providing constant relative humidity (RH) conditions. The technique has been tested on microcrystalline cel

Följderna av narkotikamissbruk kostar samhället stora summor pengar varje år. Att beräkna den exakta storleken på dessa summor är omöjligt, eftersom stora delar av den narkotikarelaterade verksamheten är olaglig. De kostnadsberäkningar man kan göra blir ungefärliga uppskattningar. Ändå är det viktigt att försöka, eftersom den kunskap man har om kostnaderna för narkotikamissbrukets konsekvenser utg

A simple second order feed-forward disturbance attenuation problem is analyzed. The problem has one free parameter, the control weight ρ in the loss function. It is found that controller structure and uniqueness for H∞ - control, in the optimal case, changes when ρ is varied. Sensitivity to initial conditions is also drastically changed. The example is simple enough to allow a solution by formula

Heusler compounds are a ripe platform for discovery and manipulation of emergent properties in topological and magnetic heterostructures. In these applications, the surfaces and interfaces are critical to performance; however, little is known about the atomic-scale structure of Heusler surfaces and interfaces or why they reconstruct. Using a combination of molecular beam epitaxy, core-level and an

Popular Abstract in Swedish Protein H - ett bakteriellt ytprotein med förmåga att binda till olika proteiner hos människa Bakgrund I vårt dagliga liv omges vi av bakterier av många olika slag. Flertalet av dessa är normalt ofarliga och många utgör den så kallade normalfloran hos människa. En del bakterier kan under vissa förhållanden ge upphov till infektion och sjukdom, men för att åstadkomma d

Time-domain fundamental solutions and Green dyadics for temporally dispersive, simple media are introduced. Second forerunner approximations to the electromagnetic fields from an electric point dipole in unbounded dispersive materials are obtained. Numerical results for two frequently used material models are presented. Moreover, surface integral representations of the electromagnetic fields in di