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Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3
Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i
In the present study, two types of micro-pin–fin configurations were fabricated on silicon surfaces by a dry etching method, i.e., staggered pin fins (#1) and aligned pin fins with empty areas (#2). The micro-pin–fin surfaces were then further modified by depositing FeMn oxide nanoparticles (∼35 nm) electrostatically for 8 h and 16 h, respectively, namely #1-8h, #1-16h, #2-8h and #2-16h. Subcooled
Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that
This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo
Our research is focused on epilepsy and the pathophysiological changes that may occur in the brain before and after epileptic seizures. About 0,7 % of the community has epilepsy and more than 30 % are resistant to any known medical therapy. We have a particular interest in the immune reaction in the brain and how it can be modulated in epilepsy. Recently, we were the first to describe an immune r
hacon.dvi Structural Mechanics OLA DAHLBLOM and JONAS LINDEMANN HACON A PROGRAM FOR SIMULATION OF TEMPERATURE AND STRESS IN HARDENING CONCRETE Detta är en tom sida! Copyright © 2000 by Structural Mechanics, LTH, Sweden. Printed by KFS i Lund AB, Lund, Sweden, May 2000. For information, address: Division of Structural Mechanics, LTH, Lund University, Box 118, SE-221 00 Lund, Sweden. Homepage: http:
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm3000/web3057.pdf - 2026-07-07
Uppsatsen har undersökt huruvida spelföretaget Star Stable Entertainment AB marknadsföring av virtuella valutor och produkter till barn bryter mot EU:s konsumentskyddslagstiftning i ljuset av Sveriges Konsumenters anmälan mot företaget. Uppsatsen har även diskuterat om direktivet om otillbörliga affärs-metoder är anpassat för den digitala miljön med hänsyn till kommissionens aktuella fitness checkThe essay analyses whether the gaming company Star Stable Entertainment AB´s marketing of virtual currencies and other virtual products against chil-dren violates EU consumer law, considering the Swedish Consumers Associ-ation’s complaint against the company. The paper also discusses whether the Unfair Commercial Practice Directive (UCPD) is fit for the digital environ-ment, given the European Com
Popular Abstract in Swedish Vår forskningsgrupp har tidigare påvisat kraftiga förändringar i genuttryck för neurotrofiner, en familj av tillväxtfaktorer för nervceller, och deras receptorer i kortikala och hippokampala nervceller vid olika hjärnskador. Det är till stora delar okänt vilken funktion neurotrofiner har efter hjärnskador, men neurotrofinsvaret skulle kunna vara en skyddande mekanism ocThis study explores the role of brain-derived neurotrophic factor (BDNF) for neuronal vulnerability and neurogenesis following cerebral ischemia in the rat. Cerebral ischemia results in selective neuronal cell loss in specific brain regions. We here demonstrate the rank order of vulnerability in two regions affected by global forebrain ischemia, i.e., hippocampus and striatum, by combining specifi
ORIGINAL PAPER Achieving Standardized Medication Data in Clinical Research Studies: Two Approaches and Applications for Implementing RxNorm Rachel L. Richesson & Susan B. Smith & Jamie Malloy & Jeffrey P. Krischer Received: 16 December 2008 /Accepted: 15 March 2009 /Published online: 3 April 2009 # Springer Science + Business Media, LLC 2009 Abstract The National Institutes of Health has proposed
https://www.teddy.lu.se/sites/teddy.lu.se/files/06032016_679_07_richesson_jms_2010.pdf - 2026-07-09
Prekonceptionell hälsa och rådgivning Kvinnor och mäns levnadsvanor inför graviditet påverkar fostret och det blivande barnets hälsa. Under våren 2019 ges en utbildning i Prekonceptionell hälsa och rådgivning vid Lunds universitet. Utbildningen är den första kursen i Sverige inom prekonceptionell hälsa, vilket gör den unik i sitt slag. Den riktar sig till barnmorskor generellt, och i synnerhet til
https://www.medicin.lu.se/sites/medicin.lu.se/files/prekonceptionell_halsa_20181218.pdf - 2026-07-09
The heterodinuclear mixed-valence complex [FeMn(ICIMP)(OAc)(2)Cl] (1) {H2ICIMP = 2-(N-carboxylmethyl)-[N-(N-methylimidazolyl-2-methyl)aminomethyl]-[6-(N-isopropylmethyl)-[N-(N-methylimidazolyl-2-methyl)]aminomethyl-4-methylphenol], an unsymmetrical N4O2 donor ligand} has been synthesized and fully characterized by several spectroscopic techniques as well as by X-ray crystallography. The crystal st
Purpose: The purpose of this thesis is to provide an understanding of how consumer-brand relationships are affected by a radical rebranding strategy of a football club’s logo. This further leads the paper to contribute to the literature of consumer-brand relationships in the special context of football. Methodology: The interpretative nature of this research calls for a qualitative research appro
A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient
Background: Malaria kills almost 1 million people every year, but the mechanisms behind protective immunity against the disease are still largely unknown. Methodology/Principal Findings: In this study, surface plasmon resonance technology was used to evaluate the affinity (measured as kd) of naturally acquired antibodies to the Plasmodium falciparum antigens MSP2 and AMA1. Antibodies in serum samp
