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Dominant-inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause CSF-1R related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r+/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit, is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r
BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and ao
In response to the challenges of their local environments, organisms produce of a large number of chemical diverse compounds with complex stereochemistry and reactive functional groups. These characteristics enable them to interact and bind specifically to biological target molecules and exert various biological activities, and have assured that Natural products continues to be an important source
Sammanfattning Problembeskrivning Konfektionsbranschen har problem med osålda produkter vilket resulterar i hög kapitalbindning. Modesvängningarna inom konfektionsbranschen blir allt snabbare vilket gör att felinköp av stora produktpartier kan bli avgörande för företagets lönsamhet. Produkter som inte säljs i ordinarie butiker måste avyttras och ett alternativ kan vara outletförsäljning. Syfte Syf
What is the significance of regulations of job contracts and wages when it comes to young people’s access to labour market? This is an issue that has attracted and continues to attract a great deal of interest in both research and politics. Proposals for deregulated employment protection and reduced entry-level pay recur regularly in public debate. In our view it is incomprehensiblehow sectors of
Introduction: Evidence-based practise is an increasing demand in occupational therapy, although multiple barriers can hinder the translation of research knowledge into practice. The article illuminates the transformation of results from a randomised controlled trial into a practice development project with future practice implementation in mind. Method: A case study was carried out, consisting of IntroductionEvidence-based practice is an increasing demand in occupational therapy (OT), although multiple barriers can hinder the translation of research knowledge into practice. The article illuminates the transformation of results from a randomised controlled trial into a practice development project with future practice implementation in mind.MethodA case study was carried out, consisting of
Amazonian ecosystems range from rainforest to open dryland vegetation, with a following decrease in biomass along the moisture gradient. Biomass can vary greatly at the ecological transition zone between grass dominated savannahs and the forest. It is not well understood if the transition zone could expand under climate change, and thereby reduce ecosystem stability and carbon storage in biomass.
Information and communication technology (ICT) is ubiquitous in tourism and this changes not only tourists’ immediate behaviour, but also what tourism is. In this way, digitalisation is shifting perceptions of when tourism starts and ends, and how we can understand the term in principal ways. The aim of this working paper is to contribute to the debate about the consequences of today´s fast digita
Design criteria for tissue-engineered materials in regenerative medicine include robust biological effectiveness, off-the-shelf availability, and scalable manufacturing under standardized conditions. For bone repair, existing strategies rely on primary autologous cells, associated with unpredictable performance, limited availability and complex logistic. Here, a conceptual shift based on the manuf
The use of participatory action research in media studies is under development and has the last years become notable as a new way of exploring changes that has taken place on the media market the last decades. Media corporations in Sweden continue shutting down local editorial offices and centralize local news reporting to the head editorials. An absence of local reporting in several rural areas iThe use of participatory action research in media studies is under development and has the last years become notable as a new way of exploring changes that has taken place on the media market the last decades. Media corporations in Sweden continue shutting down local editorial offices and centralize local news reporting to the head editorials. An absence of local reporting in several rural areas i
Hyperlocal news appears often in discussion about the future of the news media and potential alternative models. There is a strong need to analyse development of hyper-local news initiatives to better understand the needs of this sector, possibilities and challenges of collaboration between the community and media initiatives. It is important to study the phenomena in various cultural and social cHyper-local news appears often in discussion about the future of the news media and potential alternative models. There is a strong need to analyse development of hyper-local news initiatives to better understand the needs of this sector, possibilities and challenges of collaboration between the community and media initiatives. It is important to study the phenomena in various cultural and social
A series of worldwide projects concerning assessment, student outcomes and quality in higher education has revealed the need for a change in how higher education institutions assess student outcomes; however, many academics remain unconvinced. The success of assessment change arguably depends on the assessment culture within the institution. This qualitative investigation of assessment cultures dr
Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have developed a platform (
Purpose: Although persistent offenders with histories of imprisonment and violence have disproportionate high rates of psychiatric disorders, little is known of their psychiatric healthcare utilization (HCU) and HCU-associated factors. This study aimed to explore psychiatric HCU, psychiatric morbidity, and psychotropic prescription drugs in violent offenders with a history of incarceration. Method
BACKGROUND AND AIMS: The homeostatic chemokines CCL21 and CCL19 have been explored as biomarkers in cardiovascular disease prediction in patients with established cardiovascular disease, but associations between these chemokines and first-time coronary event incidence have not been investigated before. Here, we explored associations between CCL21 or CCL19 and first-time incident coronary events in
OBJECTIVE: To investigate the trajectories of work and activity impairments among people participating in a digital self-management program for osteoarthritis (OA).METHODS: We conducted an observational longitudinal study using data for baseline, 3, 6, 9 and 12 months follow ups from people participating in a digital OA treatment between June 2018 and September 2021. The Work Productivity and Acti
