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Online engagement with criminal cases is often interpreted in either punitive or crowdsourcing terms, but interactionist and ethnomethodological analyses can disclose other and more fundamental aspects. This chapter looks closely at a particular practice among posters on the Swedish platform Flashback: that of summing up the discussion ‘so far’. To sum up is a delicate and vulnerable act of rhetorOnline engagement with criminal cases is often interpreted in either punitive or crowdsourcing terms, but interactionist and ethnomethodological analyses can disclose other and more fundamental aspects. This chapter looks closely at a particular practice among posters on the Swedish platform Flashback: that of summing up the discussion ‘so far’. To sum up is a delicate and vulnerable act of rhetor

Neuronal loss and axonal demyelination underlie long-term functional impairments in patients affected by brain disorders such as ischemic stroke. Stem cell-based approaches reconstructing and remyelinating brain neural circuitry, leading to recovery, are highly warranted. Here, we demonstrate the in vitro and in vivo production of myelinating oligodendrocytes from a human induced pluripotent stem

There have been previous studies comparing experimental methods for the purpose of capturing gaseous yields at a range of global equivalence ratios. However, no work has investigated the capability of the open controlled atmosphere cone calorimeter for collecting such data where its two modes of operation are directly compared. The aim of this study is to compare carbon monoxide yields collected u

Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un

OBJECTIVE: To explore the cerebrospinal fluid (CSF) proteome in systemic lupus erythematosus (SLE) and the associations between the CSF proteomic patterns and clinical manifestations.METHODS: CSF samples from 29 female outpatients with SLE were analyzed with label-free liquid chromatography tandem mass spectrometry. Inclusion and CSF collection were conducted irrespective of clinical manifestation

In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clin

Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh

Knowledge about food structures at different length scales is key for the continued development of sustainable, tasty and healthy foods. It is critical to control, model and predict the supramolecular architecture of foods along the whole value chain: from raw materials, to their changes during processing, all the way to how products form structures during consumption and digestion. Today, advance

Recent droughts from 2017 to 2020 induced significant stress on woodland canopies across eastern Australia, resulting in widespread tree browning and mortality. However, the trajectory of post-drought recovery remains unclear, with uncertainty about whether canopy conditions are improving or continuing to decline. Identifying the key local environmental and climatic factors influencing drought-ind

This essay introduces four principles of nationalist historical narration by using the narrative strategies of the political parties the Sweden Democrats and the Danish People’s Party as examples. These narrative strategies follow the following four principles: 1. Nationalists cannot invent historical narratives solely out of figments of their imaginations. The Sweden Democrats, for example, can u

BACKGROUND: Most COVID-19-related deaths and hospitalisations occurred among older people. Natural outdoor environments influence health outcomes, but the evidence of their effect on COVID-19 outcomes among older adults is limited. This study aimed to investigate associations between residential natural outdoor environment and COVID-19-related deaths or hospitalisations among community dwellers ag

AIMS: Although age-related immune deterioration has been implicated as a mechanistic contributor to cardiovascular disease (CVD), evidence for an impairment of adaptive immune function in individuals with clinically verified presence of atherosclerosis is lacking.METHODS AND RESULTS: To test the association between atherosclerosis and immune function, we evaluated SARS-CoV-2 vaccine responsiveness

The elastic properties of amorphous TiNiSn, a promising half-Heusler system for flexible and wearable devices, were investigated using experimental and theoretical methods. Nanoindentation measurements performed on amorphous TiNiSn thin film grown by magnetron sputtering yielded an elastic (Young’s) modulus value of 132 GPa. To corroborate this result, density functional theory (DFT) calculations

Sensory traits shape animal lifestyles due to the central role they play in retrieving and processing environmental information. However, being some of the most energetically expensive tissues to build and maintain, ecological demands often modulate investment in these organs. Evidence that ecology shapes the evolution of sensory traits is plenty but is heavily biased towards vertebrates and has o

Carbon sequestration in arable soils is gaining increasing attention in global policymaking initiatives for climate-change mitigation. Large-scale assessments of soil organic carbon development in arable land are affected by the scarcity of reliable time series of soil organic carbon monitoring data and often fail to replicate observed trends or appreciate any effects induced by changes in soil ma