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The purpose of this thesis is to evaluate the compatibility of the current dominant approach in international taxation for intragroup transactions, based on arm’s length principle, with international agreements on development. In this sense, the thesis aims to explore the viability of formulary apportionment as an alternative that could reduce contradictions between international tax law and devel
High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, often discovered in advanced stages and linked to poor survival. Due to high mortality rates, there is a need for novel treatment strategies. A promising new strategy is induction of ferroptosis, which has recently been shown to synergistically induce cell death in HGSOCs in combination with MTDH-SND1 protein
Ovarian cancer is the most lethal gynecological malignancy, with treatment heavily relying on platinum-based chemotherapy. However, resistance frequently develops, posing a major clinical challenge that underscores the need for new approaches. In this study, we investigated the phosphoproteomic landscape underlying cisplatin resistance, which remains poorly understood. A parental CAOV3 ovarian can
The incorporation of electron-withdrawing B←N coordination units has emerged as an effective strategy to enhance n-type charge transport in conjugated polymers. However, the orientation of these units, whether perpendicular or parallel to the polymer backbone, profoundly influences effective conjugation, molecular packing, and ultimately charge transport properties. To address this structure-prope
Nerve surgery for unmeasurable upper extremity neuropathophysiology - such as pronator syndrome, supinator syndrome/radial tunnel syndrome, lacertus syndrome, and neurogenic thoracic outlet syndrome - remains a subject of ongoing debate due to the lack of objective reference tests confirming the diagnoses. This round table discussion outlines the perspectives of five expert surgeons navigating the
Background Increased airflow is reported as helpful in reducing the sensation of breathlessness. This systematic review aimed to assess the effectiveness of airflow on breathlessness (primary outcome, measured using a validated tool at rest or during exercise) and health-related quality of life (secondary outcome) in people with serious respiratory illness. Methods We searched Ovid MEDLINE, Embase
Organizations responsible for maintaining critical societal functions must be able to handle both events that can be foreseen and events that come more or less as surprises. Therefore, proactive risk management strategies that build on capacity to adapt to new and unforeseen circumstances must complement strategies that build on the ability to plan for events that can be anticipated on beforehand.
Biochar has a very wide range of uses in industrial processes, wastewater treatment, agriculture and soil remediation. Scaling up biochar deposits in soils has been proposed for carbon sequestration in the context of climate mitigation strategies. Although certain contaminants in feedstock can be eliminated through pyrolysis, others persist, and the process itself produces additional hazardous sub
Background: Seasonal allergic rhinitis (AR) impacts public health by affecting work productivity and quality of life. The Swedish tree pollen season starts in February with alder and hazel pollination, followed by birch and ends with oak in May. Systemic corticosteroids are often prescribed when topical treatments fail, despite limited evidence supporting their efficacy. Objective: To compare the
Excessive daytime sleepiness (EDS) is a common complaint in the general population and is associated with cardiovascular disease and increased mortality. We aimed to investigate whether sleep duration is related to excessive daytime sleepiness in the general population, both in itself and in combination with other factors. We performed a cross-sectional analysis in the population-based Swedish CAr
Introduction: Dementia remains incurable, and treatment trials are typically conducted after the symptoms manifest, potentially too late in the disease process to alter its course. Early identification and intervention during the pre-diagnosis phase offer the potential to introduce more cost-effective strategies and enhance quality of life. This review aims to scrutinise emerging evidence and pres
Research on business models for sustainability (BMfS) has primarily focused on the conceptual aspects and sustainability potential of BMfS rather than their actual impact. There is a need to understand whether BMfS have less environmental impact on society than conventional business models and in what context and conditions they can reduce impact. This research conducted a systematic literature re
In numerical combustion research, accurate chemical reaction mechanisms for heavy hydrocarbons are essential to investigate the flame dynamics of Sustainable Aviation Fuels (SAF) relative to conventional jet fuels. However, accounting for hundreds or thousands of reactions makes Finite-Rate Chemistry (FRC) Large Eddy Simulations (LES) impractical for realistic engineering scenarios. In the present
Background: In the Malmö Breast Tomosynthesis Screening Trial (MBTST), digital breast tomosynthesis (DBT) increased the detection rate of breast cancer compared to currently used digital mammography (DM). This study evaluated the cost effectiveness of DBT versus DM in Sweden using data from MBTST. Materials and method: A health economic model was used to compare a breast cancer screening programme
Optimization of machining processes, such as milling, is essential for industrial efficiency and product quality. To achieve greater efficiency, it is necessary to understand how tools wear down in different conditions in order to anticipate possible undesirable events like sudden breakage or unpredictable degradation. This study focuses on understanding tool wear in dry milling of compacted graph
Background: MR-generated acoustic noise may be particularly concerning at 7-Tesla (T) systems. Noise levels can be reduced by altering gradient output using software optimization. However, such alterations might influence image quality or prolong scan times, and these optimizations have not been well characterized. Purpose: To evaluate image quality, sound pressure levels (SPLs), and perceived noi
Accurate prediction of crack growth and strength in glued timber joints and components can be achieved by using cohesive laws in constitutive models. These laws represent the traction-separation relationship that measures the stress transmitted between crack faces in a cohesive zone, and can be obtained directly from experiments. However, studies on measuring the cohesive laws of wood adhesive bon
BACKGROUND: Neuromuscular exercise is commonly used in knee injury prevention programs and in rehabilitation following knee injury, and can also be used to address functional impairments is middle-aged and older individuals with knee and hip osteoarthritis (OA). CLINICAL QUESTION: What is neuromuscular exercise for OA? Why should clinicians use it? And how? Nine themes of common questions from exe
Pedagogical development programmes (PDPs) are important for developing teaching skills for university teaching staff. Due to participants’ different teaching roles, their professional development needs and interests may also be different. However, little is known regarding the immediate needs of university teaching staff when they enter PDPs and how these may differ according to their roles. This
The construction of heterojunctions between catalysts and cocatalysts is a widely recognized strategy to enhance catalytic activity. The precise placement of cocatalysts is widely understood to optimize charge transfer pathways and catalytic active sites. In this study, we demonstrate that site-selective decoration on an anisotropic catalyst, achieved by modulating solvent polarity and precursor r
