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The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently altered in various human cancers, including melanomas. Despite its important roles in translation and splicing, how DDX3X dysfunction specifically rewires gene expression in melanoma remains completely unknown. Here, we uncover a DDX3X-driven post-transcriptional program that dictates melanoma phenotype and poor dise

This longitudinal study examined the relationship between flexibility-activity and blood-pressure (BP) change among older adults in Japan. Our study included 452 older adults who took part in our survey in both 2012/2013 and 2017/2018. The seated systolic blood pressure (SBP) and diastolic BP (DBP) were measured both at baseline and at the 5 years follow-up. The frequencies of the different physic

Purpose: A degenerative meniscus lesion is a slowly developing process typically involving a horizontal cleavage in a middle-aged or older person. When the knee is symptomatic, arthroscopic partial meniscectomy has been practised for a long time with many case series reporting improved patient outcomes. Since 2002, several randomised clinical trials demonstrated no additional benefit of arthroscop

OBJECTIVE: To build mathematical models to evaluate the individual risk of endometrial malignancy in women with postmenopausal bleeding and sonographic endometrial thickness ≥ 4.5 mm using clinical data, sonographic endometrial thickness and power Doppler ultrasound findings. METHODS: Of 729 consecutive patients with postmenopausal bleeding, 261 with sonographic endometrial thickness ≥ 4.5 mm and

OBJECTIVES: To evaluate the long-term benefits of progressive resistance training in chronic stroke. DESIGN: A 4-year follow-up of a randomized controlled trial of progressive resistance training. SUBJECTS: Eighteen women and men (mean age 66 (standard deviation 4) from the original group of 24 post-stroke participants. METHODS: The training group (n = 11) had participated in supervised progres

Background: It has been shown previously that an anterior cruciate ligament injury may affect postural control, measured by balance in single-limb stance. To our knowledge, no studies have reported the influence of measures of impairment on postural control after such an injury. Purpose: To assess the influence of knee laxity, proprioception, and muscle strength on balance in single-limb stance an

Professional cycling combines extensive endurance training with non weight-bearing exercise, two factors often associated with lower bone mineral density (BMD). Therefore BMD was measured with dual-energy x-ray absorptiometry in 30 professional road cyclists (mean (SD) age: 29.1 (3.4) years; height: 178.5 (6.7) cm; weight: 71.3 (6.1) kg; %fat mass: 9.7 (3.2)%; (V) over dotO(2) max: 70.5 (5.5) ml .

Various proteases in the brain contribute to ischemic brain injury. We investigated the involvement of the asparaginyl endopeptidase legumain after experimental stroke. On the basis of gene array studies and in situ hybridizations, we observed an increase of legumain expression in the peri-infarct area of rats after transient occlusion of the middle cerebral artery (MCAO) for 120 mins with a maxim

Inflammation and ischemia have a synergistic damaging effect in the immature brain. The role of tumor necrosis factor (TNF) receptors 1 and 2 in lipopolysaccharide (LPS)-induced sensitization and tolerance to oxygen-glucose deprivation (OGD) was evaluated in neonatal murine hippocampal organotypic slices. Hippocampal slices from balb/c, C57BL/6 TNFR1(-/-), TNFR2(-/-), and wild-type (WT) mice obtai

OBJECTIVE: To study the information gained by extending a well-established instrument of dependence/independence in activities of daily living with a self-rating of difficulty, and to illustrate the relevance and usefulness of this combined approach with cross-national data. DESIGN AND SUBJECTS: Cross-sectional survey study data collected with 1918 very old persons in 5 European countries. METHODS

DocHdl1OnPREADYtmpTarget 119 ORNIS SVECICA 25:119–130, 2015 Abstract Introduction This study of a population of Pied Flycatchers Ficedula hypoleuca breeding in nest boxes in sub- alpine birch forest habitats at Ammarnäs, northern Sweden, was carried out in 1965–1976. When the study started it was the first to explore the breed- ing biology of the Pied Flycatcher in subalpine habitats. The species

https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-1502015nyholmeggs.pdf - 2026-05-11

NGEM01_Master_thesis_Felix_Martin_Hofmann Student thesis series INES nr Glacial history of the upper Drac Blanc catchment (Écrins massif, French Alps) Felix Martin Hofmann 2018 Department of Physical Geography and Ecosystem Science Lund University Sölvegatan 12 S-223 62 Lund Sweden Felix Martin Hofmann (2018). Glacial history of the upper Drac Blanc catchment (Écrins massif, French Alps) Glaciatio

https://www.nateko.lu.se/sites/nateko.lu.se/files/ngem01_master_thesis_felix_martin_hofmann_1.pdf - 2026-05-11

Bilingualism has become increasingly prevalent globally, with about half of the world's population being bilingual by 2012. This growing trend has prompted cognitive research to explore the effects of bilingualism on executive functions. The Bilingual Advantage (BA) theory posits that bilingual individuals experience enhanced cognitive abilities due to their practice in managing multiple langu

dc120111_pap 1..5 Performance of HbA1c as an Early Diagnostic Indicator of Type 1 Diabetes in Children and Youth KENDRA VEHIK, PHD 1 DAVID CUTHBERTSON, MS 1 DAVID BOULWARE, MS 1 CRAIG A. BEAM, PHD 1 HENRY RODRIGUEZ, MD 2 LAURENT LEGAULT, MD 3 MILA HYYTINEN, PHD 4 MARIAN J. REWERS, MD, PHD 5 DESMOND A. SCHATZ, MD 6 JEFFREY P. KRISCHER, PHD 1 THE TEDDY, TRIGR, DIABETES PREVENTION TRIAL-TYPE 1, AND T

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/20%2006032016_679_20_Vehik_Diab%20Care_2012.pdf - 2026-05-11

Problem analysis Remote sensing of drought: Sentinel data for monitoring and quantitative assessment of impacts Mitro Müller Department of Physical Geography and Ecosystem Science, Lund University Supervisors: Jonas Ardö, Lars Eklundh, Sadegh Jamali, Per-Ola Olsson Summary: A drought is an extended period when the balance between rainfall, evapotranspiration, surface flow, and subsurface flow diff

https://www.nateko.lu.se/sv/sites/nateko.lu.se.sv/files/2021-11/Mitro_Muller_Problem_Analysis.pdf - 2026-05-11

Employing the Foucauldian term ‘conduct’, this article explores how social resilience and morale became a target of state intervention in Denmark during the Cold War. ‘Psychological defence’ was a Cold War phenomenon designed to bring an imagined future war into a space of control as well as a tool for the authorities’ exercise of power in case another world war became a reality. Advocating a meth

This thesis is trying to identify and give solutions for the problems occurring in polyurethane sport surfaces in Iraq where the climate is extremely warm and dusty. One of the most important problems (called the ‘maintenance’ problem) is that the polyurethane sport surface looks very dirty because of the dust, a couple of weeks after installation of the surface the dust particles penetrates the s

Systematic data collection in high-income countries has demonstrated a decreasing burn morbidity and mortality, whereas lack of data from low- and middle-income countries hinders a global overview of burn epidemiology. In low- and middle-income countries, dedicated burn registries are few. Instead, burn data are often recorded in logbooks or as one variable in trauma registries, where incomplete o

Following the claim in Fides et Ratio that »[m]etaphysics … plays an essential role of meditation in theological research« (John Paul II 1998), I examine how the neuroscientists Christof Koch and Giulio Tononi's Integrated Information Theory (IIT) challenges a physicalist view on consciousness and even life. I discuss IIT in relation to the mathematician Norbert Wiener's Augustinian view on the orFollowing the claim in Fides et Ratio that »[m]etaphysics … plays an essential role of meditation in theological research« (John Paul II 1998), I examine how the neuroscientists Christof Koch and Giulio Tononi's Integrated Information Theory (IIT) challenges a physicalist view on consciousness and even life. I discuss IIT in relation to the mathematician Norbert Wiener's Augustinian view on the or