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BACKGROUND: Only around one-quarter of patients with cancer of the oesophagus and the gastro-oesophageal junction (GOJ) undergo surgical resection. This population-based study investigated the rates of treatment with curative intent and resection, and their association with survival.METHODS: Patients diagnosed with oesophageal and GOJ cancer between 2006 and 2015 in Sweden were identified from the

This paper addresses Jem Bendell’s concept of “deep adaptation” in the Anthropocene through the lens of everyday urban practices in contemporary Northern Europe. It proposes that this “deep adaptation” should be defined less in relation to a socio-ecological “collapse” and more through everyday occurrences in present- day urban environments.Entering into a critical conversation with Bendell’s conc

The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. Unfortunately, there is still a shortage of immune-compatible donors

Climate change poses an existential threat to humanity. It is now indisputable that the primary cause of this threat is human activity resulting in high greenhouse gas (GHG) emissions, which began during the Industrial Revolution and have continued to rapidly accelerate. The first warnings of impending and irreversible climate change were sounded decades ago, when governmental and intergovernmenta

Opening remarks – These guidelines are the result of dis-cussions within a diverse group of RSA researchers. They were approved in December 2023 by the board and selected members of the International Radiostereometry Society to update the guidelines by Valstar et al. [1]. By adhering to these guidelines, RSA studies will become more transparent and consistent in execution, presentation, reporting,

Understanding biodiversity patterns poses a persistent challenge due to the complex interconnections of ecological and evolutionary processes. The particular difficulty comes from the various processes influencing biodiversity patterns across different spatial scales. This thesis aims to enhance comprehension of community diversity patterns by employing theoretical models that are capable of gener

Online Raman scattering and in situ extinction measurement were combined in this work for qualitative and quantitative evaluations of various soot in the aerosol phase with different organic compounds.

Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are

Low-and-middle-income countries (LMICs) bear a high burden of intimate partner violence (IPV). However, there are no reviews assimilating the factors affecting risk of IPV in LMICs. This systematic review (2010–20) identifies risk and protective factors of IPV in LMICs. We followed the PRISMA guidelines to review 399 studies and included 32 studies. Studies were of ever-partnered women living in a

Sagarmatha (Everest) has long been recognised as one of the principal goals of global adventure tourism. Supported by high-altitude workers, paying climbers on Sagarmatha have the opportunity to tread in the footsteps of colonial pioneers such as George Mallory and Sir Edmund Hillary. Ever since the first attempt was made to summit Sagarmatha there has been an appreciation amongst the climbing com

Recent years have seen dramatic improvements in computer power, allowing ever more challenging problems to be approached. In light of this, it is imperative to have a quantitative model for examining chemical reactivity, both in the condensed phase and in solution, as well as to accurately quantify physical organic chemistry (particularly as experimental approaches can often be inconclusive). Simi

Non-metropolitan regions are considered more exposed to external shocks than their metropolitan counterparts, while having lower capacities to change. However, there is considerable variation among non-metropolitan regions. We argue that this variation can be captured theoretically by modelling the dynamic interplay between perceived and real opportunity spaces and agency. We empirically analyse r

This article provides a comprehensive overview of digital technologies for water use and management in agriculture, examining recent applications and future prospects. It examines key water-related challenges - scarcity, pollution, inefficient use and climate change - and shows how various digital technologies such as Remote Sensing, Artificial Intelligence, the Internet of Things, Big Data, Robot