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Popular Abstract in Swedish Prostatacancer är en mycket vanlig form av cancer, och det har visats att cirka hälften av alla män över 70 år har tumör i prostata. Prostatacancer är ofta en latent form av cancer, vilket innebär att den sällan ger kliniska symtom förrän i ett framskridet stadium. Sedan PSA testet började användas på 90-talet har antalet diagnostiserade fall av prostatacancer blivit alProstate cancer is currently the most common form of cancer in Sweden. Currently, the only biomarker used in the clinic is serum PSA, and there is a great need for new biomarkers that may increase the diagnostic and prognostic information so that better predictions can be made, and treatment may be tailored. Here, we have investigated two proposed biomarkers microseminoprotein-β (MSMB) and cystein

Several risk factors for severe non-proliferative and proliferative retinopathy in type 1 diabetes mellitus have been proposed without explaining the rapid progression of retinopathy in some patients. Since GAD65 autoantibodies (GAD65Abs) are detected against glutamic acid decarboxylase (GAD), which is mainly expressed in islets and nervous tissue in type 1 diabetic patients, the aim of the presen

Acute cellular rejection (ACR) the first year after heart transplantation (HT) and its impact on survival was investigated. All 215 HT-patients at our centre 1988-2010, including 219 HTs and 2990 1(st) -year endomyocardial biopsies (EMBs), were studied. "Routine"-EMBs obtained 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24, 32, 40 and 52 weeks after HT, and "additional clinically indicated" (ACI) EMBs, were

The thesis examines various aspects of "electricity hypersensitivity" (EH). An empirical investigation of a group of persons suffering from EH was carried out, a part of the group being treated psychologically according to cognitive- behavioural principles in a controlled outcome study. The major findings concern an explanatory-model of EH, the the assessment of characteristics of EH-sufferers and

Popular Abstract in Chinese 在世界許多地方蛾類幼蟲是主要的農業害蟲，但也有蛾類養殖業為獲取其絲綢蠶繭，例如家蠶。其實它也是第一個也是最好的研究揮發性有機分子用於傳遞信息的昆蟲研究模型。一般來說是雌蛾釋放信息素通過很長的距離來吸引雄性同類，而且具有出色的靈敏度和特異性。至今有記載的蛾類信息素都屬於同一類化合物(脂肪酸衍生物), 在信息素腺體內合成。信息素的生物合成涉及到脂肪酸的脫飽合，碳鏈縮短，並最終還原，乙酰化或氧化成醛等。這些反應過程中的酶已經進化到具有專一性，專門用於生產複雜的化學信號，使得蛾類的信息素存在豐富的化學多樣性。在本論文中，首先對幾個脫飽和酶進行研究。第一篇文章對冬尺蠖的脫飽合酶進行克隆並在酵母中通過異源表達證明了它具有把順十一,順十四,順十七-二十碳三烯酸轉化成順十一,順十四,順十七,十九-二十碳四烯酸的能力。這是有史以來第一個對甲基端脫飽合酶Moth caterpillars are major agricultural pests in many parts of the world. In general female moths attract male mates with their pheromone over long distance. Most of the described moth pheromones belong to the same class of chemical compounds, fatty acid derivatives that are produced de novo in the pheromone gland. The pheromone biosynthesis involves desaturation, chain-shortening by β-oxidation

Popular Abstract in Swedish Medfödda hjärtfel (congenital heart defects,CHD) förekommer hos nästan 1 % av alla födda barn. En del lindriga hjärtfel spontanläker, men de flesta hjärtfel måste opereras i läkande eller lindrande syfte. Stora kirurgiska framsteg har gjorts på senare år. Hjärtfel som tidigare icke ansågs möjliga att åtgärda kan nu opereras, och många operationer utföres tidigt i livet,The aim of this study was to evaluate new MR techniques permitting qualitative and quantitative analysis of cardiac function and measurement of velocity and flow, and later on contrast-enhanced MR angiography, techniques largely unexplored in children with CHD. Infants with tetralogy of Fallot and pulmonary atresia with ventricular septal defect were examined pre-operatively. MRI was found to be a

Activating mutations of codon 816 of the Kit gene have been implicated in malignant cell growth of acute myeloid leukemia (AML), systemic mastocytosis and germ cell tumors. Substitution of aspartic acid with valine (D816V) renders the receptor independent of ligand for activation and signaling. Wild-type c-Kit is a tyrosine kinase receptor that requires its ligand, stem cell factor (SCF), for acti

Popular Abstract in Swedish Polyklorerade bifenyler (PCB) är ett samlingsnamn för ett antal kemiska föreningar. De utmärker sig genom att de har en god elektrisk isoleringsförmåga och tålighet för höga temperaturer, och de har därför använts i bl.a. transformatorer och kondensatorer men även som mjukgörare i plaster och färger. Sedan det visat sig att exponering för PCB innebar allvarliga hälsoeffPersistent organochlorine compounds (POC), such as polychlorinated biphenyls (PCB) and dioxins, are long-lived and highly lipophilic compounds which are present in all biota today. In Sweden, one of the major exposure routes for POC is through the consumption of fatty fish from the Baltic Sea, which is off the east coast of Sweden, and one of the most highly exposed populations is the fishermen's

History plays an important role in the philosophy of human rights, more so than in philosophical discussions on related concepts, such as justice. History tends to be used in order to make it credible that there is a tradition of rights as a moral idea, or an ethical ideal, that transcends national boundaries. In the example that I investigate in this chapter, this moral idea is tightly spun aroun

Introduction: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors.Methods: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standa

Purpose: Although advances in Hodgkin lymphoma (HL) treatment have led to improved disease-free survival, this has been accompanied by an increased risk of second cancers. We sought to quantify the second cancer risks and to investigate the impact of family history. Patients and Methods: Using the Swedish Family-Cancer Project Database, we identified 9,522 individuals with primary HL diagnosed bet

Desert vernacular architecture is a product of a sustainable building cycle. Desert local inhabitants inherited the traditional way of building from their ancestors developed and then transferred knowledge from one generation to another. This building and cultural cycle is about to disappear in many desert vernacular settlements of the world. Global ambitions and socio-economic developments are so

Background: Causes and consequences of mesenteric embolization after endovascular aorto-iliac procedures have not been studied adequately. Methods: Consecutive patients with mesenteric embolization after endovascular aorto-iliac intervention between 2011 and 2015 (case-group, n = 9) were investigated and compared with age, gender and procedure-matched random controls (n = 36). Results: Compared to

The 2010 population and housing census in Ghana revealed that more than half of the Ghanaian population lived in urban centers. Critical to the phenomenon of urbanization is the question of how to sustainably feed the urban population especially the urban poor as rapid urbanization has the tendency to urbanize poverty. This has led to renewed policy debate about the implications of farming in citi

Introduction: Clinical trials have shown promising results for extended half-life factor VIII concentrates but little is known about individuals' valuation of haemophilia treatment attributes. Aim: To assess patient/caregiver and population valuation of treatment attributes of prophylactic regimens for people with severe haemophilia A. Methods: Members ≥16 years of the Swedish Haemophilia Society

Background: In several studies, patients with alcohol dependence treated with the opioid antagonist naltrexone have shown fewer relapses to heavy drinking than those receiving placebo. An interaction between the naltrexone effect and the type of psychological therapy has been observed. Methods: A 6-month, double-blind, placebo-controlled, parallel-group study was performed at 10 different investi

Clonality studies of mature cells suggest that the primary transformation event in myelodysplastic syndrome (MDS) most frequently occurs in a myeloid-restricted progenitor, a hypothesis supported by recent studies of purified CD34(+)Thy1(+) hematopoietic stem cells (HSCs) in cases with trisomy 8 (+8). In contrast, we recently demonstrated that a lymphomyeloid HSC is the target for transformation i

Structural and mechanistic aspects of orthoplatination of acetophenone and benzaldehyde oximes by the platinum(II) sulfoxide and sulfide complexes [PtCl2L2] (2, L = SOMe2 (a), rac-SOMePh (b), R-SOMe(C6H4Me-4) (c), and SMe2 (d)) to afford the corresponding platinacycles cis-(CS)-[Pt-II(C6H3-2-CR'=NOH-5-R)CI(L)] (3, R, R' = H, Me) have been investigated. The reaction of acetophenone oxime with sulfo