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The Impact of Different Drying Techniques and Controlled Storage on the Development of Advanced Glycation End Products in Skim Milk Powders Using Isotope Dilution ESI-LC-MS/MS

The impact of different drying techniques and storage conditions on the formation of carboxymethyl lysine (CML) as an advanced glycation end product (AGE) was investigated in various pilot-scale produced skim milk powders (SMP). CML, an indicator of advanced stages of the Maillard reaction, was analyzed by isotope dilution ESI-LC-MS/MS after drying and at intervals during storage for 200 days. The

Design and Implementation of RF Kickers in MAX IV

The MAX IV facility in Lund, Sweden, consists of two storage rings for production of synchrotron radiation, and a full-energy LINAC for top-up injections. The LINAC also delivers short high-intensity electron bunches to a short pulse facility. MAX IV was inaugurated in June 2016, and the larger 3 GeV ring has been delivering light to users since November 2016. In this thesis, the design and implem

The city logistics-based business model: a series of components

PurposeEmpirical studies show that 96% of the city logistics projects failed to become permanent, mainly due to the lack of sustainable business models (Quak et al., 2014; Malhene et al., 2012). Accordingly, it was concluded that the need of business model specifically designed for city logistics is high (Benjelloun, 2010). However, researchers have yet to describe the components and their interre

Activation of complement by pigment epithelium-derived factor in rheumatoid arthritis

The aim of this study was to identify molecules that trigger complement activation in rheumatic joints. C4d, the final cleavage product of C4 activation, is found in the diseased joint and can bind covalently to complement-activating molecules. By using a highly specific Ab against a cleavage neoepitope in C4d, several molecules that were specifically bound to C4d were identified from pooled synov

Cloud droplet nucleation scavenging in relation to the size and hygroscopic behaviour of aerosol particles

The size distributions and hygroscopic growth spectra of aerosol particles were measured during the GCE cloud experiment at Great Dun Fell in the Pennine Hills in northern England. Hygroscopic growth is defined as the particle diameter at 90% RH divided by the particle diameter at 10% RH. The fraction of the aerosol particles scavenged by cloud droplets as a function of particle size was also meas

Early and exudative age-related macular degeneration is associated with increased plasma levels of soluble TNF receptor II

PURPOSE: We have recently identified homeostatic alterations in the circulating T cells of patients with age-related macular degeneration (AMD). In cultures of retinal pigment epithelial cells, we have demonstrated that T-cell-derived cytokines induced the upregulation of complement, chemokines and other proteins implicated in AMD pathogenesis. The purpose of this study was to test whether increas

Optimal Performance of Advanced Radiating Structures

Requirements on radiating structures are constantly increasing, demand for faster speed, smaller size, and higher reliability drives today's technical development. However, for electrically small structures, less than half-a-wavelength in size, performance is fundamentally limited by physical size. This thesis explores how to construct and calculate physical bounds for advanced antennas and comple

Protein-water interactions studied by molecular dynamics simulations

Most proteins have evolved to function optimally in aqueous environments, and the interactions between protein and water therefore play a fundamental role in the stability, dynamics, and function of proteins. Although we understand many details of water, we understand much less about the protein-water interface. In this thesis we use molecular dynamics (MD) simulations to cast light on many struct

A Method Proposal for Early Software Reliability Estimation

Presents a method proposal for estimation of software reliability before the implementation phase. The method is based upon a formal description technique and that it is possible to develop a tool for performing dynamic analysis, i.e. locating semantic faults in the design. The analysis is performed by applying a usage profile as input as well as doing a full analysis, i.e. locating all faults tha

Software Reliability Estimations through Usage Analysis of Specifications and Designs

This paper presents a method proposal for estimation of software reliability before the implementation phase. The method is based upon that a formal specification technique is used and that it is possible to develop a tool performing dynamic analysis, i.e., locating semantic faults in the design. The analysis is performed with both applying a usage profile as input as well as doing a full analysis

Seasonal Variation in Human Salivary Cortisol Concentration

Measurement of cortisol concentration can contribute important information about an individual's ability to adjust to various environmental demands of both physical and psychosocial origin. However, one uncertainty that affects the possibilities of correctly interpreting and designing field studies is the lack of observations of the impact of seasonal changes on cortisol excretion. For this reason

Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment

Most fractures heal uneventfully but some evolve into nonunions. Autologous bone graft is the gold standard for stimulating healing. However, donor site morbidity, and limited graft supply make alternatives interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are available in recombinant form for local application in nonunions and stimulate differenti

Analysis of strongly interfering slow frequency-hopping systems

In this report slow frequency-hopping systems are analyzed with respect to the probability of successful transmission of packets, and with respect to the throughput. It is assumed that collisions result in a loss of all information contained in the colliding packets, irrespective of the distance between the units of the system. Units transmit packets of different types with a certain probability,

The role of ultrasound in the management of women with acute and chronic pelvic pain

Pelvic pain (acute or chronic) is a common symptom in women of all ages. Ultrasonography is the least invasive investigative tool available to the clinician. Transvaginal probes produce high-resolution images of the pelvic organs, providing reliable and reproducible information without the need for a full bladder. Common gynaecological pathology involving the uterus, Fallopian tube and/or the ovar

Harmonic Modeling of the Motor Side of an Inverter Locomotive

An AC-voltage source feeding an electric network results ina periodic excitation of the network. In steady state, allcurrents and voltages will be periodic with cycle time corresponding to thefrequency of the voltage source. If the network is linear, all signalsare sinusoidal and the network is solved using traditional methods.If the network contains components with nonlinear or switchingdynamics,

Fluorescence Spectroscopy Measurements in Ultrasonic Navigated Resection of Malignant Brain Tumors

Background and Objective: Glioblastoma multiforme is a highly malignant primary brain tumor. It has no border but at best a marginal zone, however, invisible to the surgeon. An optical touch pointer (OTP) enabling differentiation of healthy and tumor tissue by means of fiber-optic fluorescence spectroscopy has been developed. In combination with an ultrasonic navigation system, the OTP may be used

Cassava Commercialization in Southeastern Africa

Purpose – Cassava production surged noticeably in Southeastern Africa beginning in the 1990s. The purpose of this paper is to examine the commercial responses and food security consequences of cassava production growth in the region. Design/methodology/approach – The paper incorporates a mix of quantitative analysis, based primarily on original analysis of national farm household survey data, toge

Ear Reconstruction. Clinical and physiological evaluations.

Popular Abstract in Swedish Mikroti är en medfödd avvikelse där ytterörat inte utvecklats normalt. Defekten kan variera från att örat nästan är normalt till att det saknas helt och hållet, s.k. anoti. I Sverige inträffar detta i c:a 2 fall per 100 000 nyfödda. Pojkar drabbas i större utsträckning och höger sida är den vanligaste. Båda sidor drabbas i c:a en tiondel av fallen. Förträngning av yttreMicrotia is a congenital malformation where the auricle is not fully developed. In some cases the malformation is complete and the auricle is absent. In Sweden the incidence of microtia is about 2 per 10,000 births. Reconstruction of the external ear is possible by using autologous rib cartilage in three surgical steps: rib cartilage transplantation, ear elevation and final adjustments. Although t

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells

The release gamma-aminobutyric acid (GABA) and ATP from rat beta cells was monitored using an electrophysiological assay based on overexpression GABAA or P2X2 receptor ion channels. Exocytosis of LDCVs, detected by carbon fiber amperometry of serotonin, correlated strongly (similar to 80%) with ATP release. The increase in membrane capacitance per ATP release event was 3.4 fF, close to the expecte

Menorrhagia and minor bleeding symptoms in women on oral anticoagulation.

Background Oral anticoagulation (OA) is a common treatment with a known risk of fatal or major bleeding, but also minor bleeding symptoms and menorrhagia can cause substantial discomfort and necessitate medical or surgical interventions. The extent of these side effects is however not previously reported. The objective of this study is to assess the frequency of minor bleeding symptoms and menorrh