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Antibody-dependent allostery of the M1 protein

Den förrädiska antikroppen Streptokocker är en lömsk bakterie som har många olika sätt att ta sig runt vårt immunförsvar. Den kan låtsas vara en del av vår kropp genom att klä sig själv i en proteinkapsel som är väldigt likt ett mänskligt protein, bryta ned våra celler med hjälp av utsöndrade gifter och använda vårt immunförsvar mot oss genom att binda antikroppar till sig själv. En virulensfaktoThe Group A streptococcus (GAS) (Streptococcus pyogenes) is a significant human pathogen known for causing a diverse range of diseases, spanning from mild diseases such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. Its virulence comes from a plethora of immune evasion mechanisms, but the M protein with its hypervariable region and ability to bind human proteins, stands

Microscopy of stained smears of vaginal secretion in the diagnosis of recurrent vulvovaginal candidosis

This study was undertaken to determine the value of stained smears from the vaginal introitus and the posterior vaginal fornix for detection of candida morphotypes in the diagnosis of recurrent vulvovaginal candidosis (RVVC) in cases with an assumed novel attack of the condition, and to compare the value of microscopy of such smears in relation to candida culture, vaginal pH-determinations and leu

Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes

Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei

Methane and carbon dioxide fluxes over a lake : Comparison between eddy covariance, floating chambers and boundary layer method

Freshwaters bring a notable contribution to the global carbon budget by emitting both carbon dioxide (CO2) and methane (CH4) to the atmosphere. Global estimates of freshwater emissions traditionally use a wind-speed-based gas transfer velocity, kCC (introduced by Cole and Caraco, 1998), for calculating diffusive flux with the boundary layer method (BLM). We compared CH4 and CO2 fluxes from BLM wit

Determination of specific surface by the BET method

The theoretical background of the adsorption isotherm equation of Brunauer, Emmett and Teller is reviewed, together with the experimental techniques available for measuring physical adsorption of gases by solids. Examples are given to show how such measurements are used to determine the specific surface of constructional materials.

Cécile Brokelind

Professor Contact details Email: cecile [dot] brokelind [at] har [dot] lu [dot] se Phone: +46 46 222 33 67Organisation Department of Business Law Room number: EC2-359 Service point: 10 WebpageCécile Brokelinds profile in Lund University research portalOther affiliations Researcher Lund Tax Academy Publications Displaying of publications. Sorted by year, then title. Filter by type AllBookBook chapt

https://www.lusem.lu.se/cecile-brokelind - 2026-05-31

Brevmall

Brevmall 4 Kurslitteratur för FRAB05 La femme dans la littérature française, 7,5 högskolepoäng fastställd av Lärarkollegium 3 2011-06-29 för att gälla från HT11. Duras, Marguerite (1984). L’Amant . Paris: Minuit Ernaux, Annie (1981). La femme gelée . Paris: Folio Gallimard Gide, André (1973). L’École des femmes . Paris: Folio Gallimard Molière (1972). L’École des femmes . Molière OEuvres Complètes

https://www.sol.lu.se/media/utbildning/dokument/kurser/FRAB05/20112/FRAB05_fr_ht11.doc - 2026-05-31

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Rezension des Bandes „Die Rousseau-Frage – ökologisch definiert”, herausgegeben von Udo E. SimonisDer Band ist hervorgegangen aus einer öffentlichen Ausschreibung aus Anlass des zehnjährigen Jubiläums des „Jahrbuchs Ökologie” im Jahre 2001 zur Fragestellung: „Hat der Fortschritt der Wissenschaften und Künste dazu beigetragen, die Umwelt zu schützen und zu bewahren?” Diese Thematik lehnt sich an di

Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency

Homozygous C2 deficiency (C2D) is the most common deficiency of the classical complement pathway in Western countries. It is mostly found in patients with autoimmune disease or susceptibility to bacterial infections and in healthy persons. We wished to assess to what extent other immunological factors might explain differences of susceptibility to infections in C2D. For this reason, 44 Swedish pat

Analysis of the molecular interplay between Streptococcus pyogenes and its human host

The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl

The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease

In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses

BspK, a serine protease from the predatory bacterium Bdellovibrio bacteriovorus with utility for analysis of therapeutic antibodies

The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit

The derivation of first- and second-order backpropagation methods for fully-connected and convolutional neural networks

We introduce rigorous theory for deriving first and second order backpropagation methods for Deep Neural Networks (DNN) whilst satisfying existing theory in DNN optimization. We begin by formally defining a neural network with its respective components and state the first and second order chain rule with respect to its partial derivatives. The partial derivatives in the chain rule formula are rela