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BspK, a serine protease from the predatory bacterium Bdellovibrio bacteriovorus with utility for analysis of therapeutic antibodies
The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit
Analysis of the molecular interplay between Streptococcus pyogenes and its human host
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl
Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency
Homozygous C2 deficiency (C2D) is the most common deficiency of the classical complement pathway in Western countries. It is mostly found in patients with autoimmune disease or susceptibility to bacterial infections and in healthy persons. We wished to assess to what extent other immunological factors might explain differences of susceptibility to infections in C2D. For this reason, 44 Swedish pat
The derivation of first- and second-order backpropagation methods for fully-connected and convolutional neural networks
We introduce rigorous theory for deriving first and second order backpropagation methods for Deep Neural Networks (DNN) whilst satisfying existing theory in DNN optimization. We begin by formally defining a neural network with its respective components and state the first and second order chain rule with respect to its partial derivatives. The partial derivatives in the chain rule formula are rela
Marine Le Pen som partiledare för Front National : en förnyad diskurs?
The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease
In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses
Preparation of Staphylococcal Protein A Imprinted Supermacroporous Cryogel Beads
Functional connectome fingerprinting across the lifespan
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Redox control of exocytosis - Regulatory role of NADPH, thioredoxin, and glutaredoxin
Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling molecule for exocytosis in neuroendocrine cells. In pancreatic beta-cells, glucose acutely raised the NADPH-to-NADP(+) ratio and stimulated insulin release in parallel. Furthermore, intracel
Microscopy of stained smears of vaginal secretion in the diagnosis of recurrent vulvovaginal candidosis
This study was undertaken to determine the value of stained smears from the vaginal introitus and the posterior vaginal fornix for detection of candida morphotypes in the diagnosis of recurrent vulvovaginal candidosis (RVVC) in cases with an assumed novel attack of the condition, and to compare the value of microscopy of such smears in relation to candida culture, vaginal pH-determinations and leu
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Rezension des Bandes „Die Rousseau-Frage – ökologisch definiert”, herausgegeben von Udo E. SimonisDer Band ist hervorgegangen aus einer öffentlichen Ausschreibung aus Anlass des zehnjährigen Jubiläums des „Jahrbuchs Ökologie” im Jahre 2001 zur Fragestellung: „Hat der Fortschritt der Wissenschaften und Künste dazu beigetragen, die Umwelt zu schützen und zu bewahren?” Diese Thematik lehnt sich an di
Forteckning over topographica utlandska avd 1
1 1 Universitetsbiblioteket, Lunds universitet DE LA GARDIESKA ARKIVET TOPOGRAPHICA, utländska avdelningen Förteckning reviderad av Per Stobaeus 2011 Inledning Den utländska avdelningen av Topographica i De la Gardieska arkivet har ett mycket blandat innehåll från perioden 1545–1837. Här finns handlingar från England, Frankrike, Grekland, Holland, Italien, Kurland, Litauen, Nordamerika, Polen, Rys
https://www.ub.lu.se/en/sites/ub.lu.se.en/files/forteckning_over_topographica_utlandska_avd_1.pdf - 2026-05-31
Handkirurgi och dess specifika omvayrdnad
Handkirurgi och dess specifika omvårdnad U PP D R A G SU TB IL D N IN G Institutionen för hälsovetenskaper erbjuder utbildningar som genomförs av lärare vid Lunds universitet och i många fall i samarbete med arbetslivet - en garanti för både ämnesmässig bredd och aktualitet, ett vetenskapligt djup och en modern pedagogik. Institutionens uppdragsverksamhet sker i samarbete med Lund University Commi
https://www.medicin.lu.se/sites/medicin.lu.se/files/handkirurgi_och_dess_specifika_omvayrdnad.pdf - 2026-05-31