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Next-generation sequencing (NGS) has transformed the study of antibody repertoires by enabling high-throughput, in-depth analysis of immune diversity and antigen-driven selection. When paired with in vitro display technologies, NGS offers unparalleled resolution in characterizing antibody libraries, but also presents substantial computational challenges due to the highly variable nature of antibod
The Million Homes Programme, launched in Sweden during the 1960s, resulted in the construction of over one million homes to address a national housing shortage. A majority of the houses consist of linear block buildings, many of which now require renovation. Moreover, climate change and increasing energy demands have put pressure on the building sector to reduce emissions and improve energy perfor
Syftet med uppsatsen är att undersöka på vilket sätt könsroller och könsnormer tar sig uttryck i realityserien Love is Blind Sverige säsong 2. För att möjliggöra detta har en kvalitativ tematisk innehållsanalys av utvalda avsnitt och händelser utförts. Uppsatsens teoretiska ramverk innefattar teorier kring reality-tv, genus och könets performativitet i reality-tv. Baserat på studiens analys kunde
Fire safety design for complex buildings often relies on the Performance-based Design approach which assesses the margin of safety by comparing Available Safe Egress Time with Required Safe Egress Time. However, most current modelling tools often operate independently or at most with one-way coupling. This potentially reduces the accuracy of fire safety assessments by failing to capture dynamic in
This thesis was developed in partnership with SCM Group, a leading Italian manufacturer of material-cutting machinery operating an extensive international network of production sites and clients. Because of the magnitude of its operations, SCM’s technical support teams manage a large volume of support tickets-records submitted by clients on a daily bases: structured reports documenting machine fai
Metasurfaces are two-dimensional arrays of sub-wavelength structures often arranged in a periodic lattice. During recent years, metasurfaces have emerged as one of the most promising platforms to shape electromagnetic waves using compact devices, exhibiting extraordinary control over the light amplitude, polarization and phase. Starting with metallic materials, metasurface research has shifted tow
The rapid expansion of the plant-based beverage sector has increased the demand for high-performance, barista-grade oat drinks that are capable of withstanding the thermal and acidic stresses of coffee applications. This master’s thesis, conducted in collaboration with Cerealiq AB, evaluates the efficacy of six specific enzymatic treatments in modifying the structural and physical properties of oa
Peptide therapeutics offer advantages in specificity and affinity, yet the potential propensity to self-associate and aggregate poses a challenge for the development of stable oral formulations. This master’s thesis evaluates the utility of the fluorescent dye Thioflavin T as a structural probe to monitor the aggregation of glucagon-like peptide-1 receptor agonists, specifically Liraglutide and Se
Reliable ankle torque measurements are important in rehabilitation, where strength assessments are used to evaluate recovery and guide treatment. Isokinetic dynamometers, such as the Biodex system, are commonly used to provide controlled measurements of joint torque. However, these measurements rely on the ankle being held in a stable and reproducible position. Mechanical play in the ankle-attachm
This thesis examines how young people in Finland make sense of profit-oriented drug selling and construct drug dealer identities. Drug use and related harms have increased globally in recent years. In Finland, an increase in minors selling drugs for financial profit has been noticed by the police and a non-governmental youth work organization Children of the Station. The aim of this thesis is to e
In this study, a comprehensive investigation of a set of phytochemicals to identify potential inhibitors for the Forkhead box protein M1 (FOXM1) was conducted. FOXM1 is overexpressed in glioblastoma (GBM) cells and plays a crucial role in cell cycle progression, proliferation, and invasion. FOXM1 inhibitors have shown promising results in preclinical studies, and ongoing clinical trials are assess
Mixed-phase clouds contain both supercooled cloud liquid and ice crystals. In principle, precipitation may be initiated either by the liquid phase or by the ice phase. Ice crystals may grow by vapor diffusion to become snow ("ice crystal process"), forming "cold"precipitation. Equally, cloud droplets, when large enough, coalesce to form "warm"precipitation by the "warm rain process."Warm rain coul
The Nobel Prize in Literature to the Austrian writer Peter Handke in 2019 gave new attention to one of the basic, and historically highly disputed (cf. Espmark 2001, 2021), questions in relation to the practice of the world’s most important literary prize – on what grounds, aesthetic or otherwise, does the Swedish Academy award the prize? In the aftermath of the 2019 prize to Handke, there was an
Cork oak and pine bark, two of the most prolific byproducts of the European forestry sector, were assessed as biosorbents for eliminating potentially toxic elements (PTEs) from water-based solutions. Our research suggests that bioadsorption stands out as a viable and environmental eco-friendly technology, presenting a sustainable method for the extraction of PTEs from polluted water sources. This
Purpose: Despite increasing focus among scholars and practitioners on the design of product-service systems (PSS), there exists no compilation of current knowledge on the role played by small and medium-sized enterprises (SMEs) in designing such systems. Thus, this paper sets out to identify and organise the existing research and suggest questions for future research. Design/methodology/approach:
Physiologically based pharmacokinetic (PBPK) models offer the ability to simulate and predict the biodistribution of radiopharmaceuticals and have the potential to enable individualised treatment planning in molecular radiotherapy. The objective of this study was to develop and implement a whole-body compartmental PBPK model for peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE
Aim: Previous research has indicated that preoperative beta blocker therapy is associated with a decreased risk of complications after surgery for rectal cancer. This is thought to arise because of the anti-inflammatory activity of the drug. These results need to be reproduced and analyses extended to other drugs with such properties, as this information might be useful in clinical decision-making
Background: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic variant impact, particularly where relevant to disease. The five complete editions of the CAGI community experiment comprised 50 challenges, in which participants made blind predictions of phenotypes from genetic data, and these were evaluated by independ
Background: Histological grade is a well-known prognostic factor that is routinely assessed in breast tumours. However, manual assessment of Nottingham Histological Grade (NHG) has high inter-assessor and inter-laboratory variability, causing uncertainty in grade assignments. To address this challenge, we developed and validated a three-level NHG-like deep learning-based histological grade model (
