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ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma

The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally unknown. Here, the immune landscape of ASCL1-positive lung adenocarcinomas was characterized by immunohistochemistry. Furthermore, ASCL1

Att lägga ett pussel - om bevisningen i indiciemål

I framställningen studeras rättstillämparens bedömning av indiciebevisning i praktiken, vid såväl friande som fällande domar. Syftet med examensarbetet är att utreda och klarlägga bevisningens styrka i indiciemål i förhållande till beviskravet ställt bortom rimligt tvivel. Ett högt ställt beviskrav för en fällande dom i brottmål är ett av de viktigaste kraven för rättssäkerheten i Sverige. För aIn this essay the judgements of the courts of law regarding circumstantial evidence, both in cases of convictions and in verdicts of acquittal, are analysed. The purpose of this thesis is to investigate and elucidate the strength of circumstantial evidence in relation to the requirement of beyond reasonable doubt. An ambitious evidential requirement for a conviction in criminal cases is one of the

Dimensionering av bärverk i stål enligt Eurokod - En jämförelse med BKR på grundnivå

Nya gemensamma EU-normer för byggande, Eurokoder, har utvecklats och skall i praxis börja användas i Sverige senast den 2:e maj 2011 då den nya Plan- och Bygglagen (PBL) träder i kraft. Till Eurokoden hör en nationell bilaga där varje nation tillåts att göra vissa nationella val. Detta arbete redogör för hur allmänna dimensioneringsprinciper och beräkning av laster och dimensionering av enkla stål

Brachytherapy of Squamous Cell Carcinoma in the Lip MDR to PDR Treatment Conversion

En vanlig typ av behandling vid cancer är strålbehandling. Tekniken har utvecklats mycket de senaste åren och med ny teknik kommer bättre behandlingsresultat och bättre skydd mot strålningen. När det är dags att byta ut en äldre behandlingsteknik mot en nyare är det en del faktorer som måste undersökas. Detta arbete undersöker just de möjligheterna vid en ny typ av behandling för läppcancer. StrIntroduction: From 1988 – 2004, patients with squamous cell carcinoma in the lower lip were treated with medium dose rate (MDR) 192Ir wires using a manual afterloading tech-nique. An average of 3 wires were used, each with a mean length of 36 mm (range 27 – 65 mm) and a mean dose rate of 4.5 Gy/h (range 1.8 – 8.7 Gy/h). The average prescribed dose was 21.5 Gy (range 21.0 – 32.6 Gy) at the 85% isod

Impact of Central Nodes in Information Propagation over Graphs

Många system kan representeras som grafer, alltifrån neurala nätverk och transportnätverk till något så vardagligt som våra umgängeskretsar. Om exempelvis Andrea är vän med Jona- than, så kan vi rita ut Andrea och Jonathan som var sin prick på ett paper och låta deras vän- skap representeras av en linje. På samma sätt kan vi enkelt lägga till fler personer (prickar) och rita fler linjer till alla There are many systems which can be represented as graphs, to say the least the networks in which we communicate with each other. Thorough understanding of graph structures enables better predictions of the dynamics in real life networks, such as the spreading of a disease in a community or failure propagation in a system. This thesis investigates information propagation over connected undirected

The Role of Urban Planning in Counteracting Segregation: The Case of Pinelands, South Africa

Segregation är ett vanligt fenomen som uppstår över hela världen. De negativa konsekvenserna av boendesegregation har visat sig vara många för de som bor i mindre välbärgade stadsdelar. Bland konsekvenserna finns bland annat hälsorelaterade motgångar, men även sämre förutsättningar under skolgången och i det framtida arbetslivet har konstaterats. Sydafrika lämpar sig väl för att studera segregatioSegregation is a common phenomenon arising worldwide. Residential segregation has been shown to have several negative consequences for people living in less wealthy neighbourhoods, such as health-related setbacks and being less likely to cope with school. South Africa is an especially well-suited country to study segregation and methods to counteract it to achieve better integration and more harmo

Ska vi öppna Pandoras ask? En studie om avtalslagens behov av reformering

Med utgångspunkt i avtalslagen syftar denna uppsats till att utreda och analysera argumenten för och emot behovet av lagreglering inom avtalsrätten och därmed få en ökad förståelse för lagstiftningens och prejudikatets betydelse. Uppsatsens frågeställning är: Utifrån vilka aspekter och argument kan det hävdas att avtalslagen behöver reformeras alternativt bevaras som den är? Metoden för uppsatsenBased on the Swedish Contract Law (avtalslagen) this essay aims to investi-gate and analyze the arguments pro and contra the need for legal regulation within contract law and thereby gain an increased understanding of the im-portance of legislation and precedent. The question of the thesis is: Based on which aspects and arguments can it be argued that the contract law needs to be reformed or prese

Impact of the APOE genotype, early-life infection, and sex in Alzheimer’s disease pathology

Anna Sundgren, MOBM02 September 23 - January 24, Department of Biology, Lund University Baby infection as Alzheimer´s disease protection? The characteristic pathology of Alzheimer’s disease (AD) includes accumulation of amyloid-beta protein as plaques, and tau-protein as tangles in the brain. Another important feature of the disease is neuroinflammation. One important risk gene for AD is the apo

Improving Chip Design Enablement for Universities in Europe - A Position Paper

The semiconductor industry is pivotal to Europe's economy, especially within the industrial and automotive sectors. However, Europe faces a significant shortfall in chip design capabilities, marked by a severe skilled labor shortage and lagging contributions in the design value chain segment. This paper explores the role of European universities and academic initiatives in enhancing chip design ed

Tracking neural dynamics of the relational eye-movement effect during memory retrieval

Eye movements do more than gather visual input – they actively contribute to the formation and retrieval of relational memories by linking information across space and time. During retrieval, gaze patterns often reflect memory reactivation well before an explicit response is made, a phenomenon known as the relational eye-movement effect. While this effect appears closely associated with hippocampa

Looking for Memory : Tracking Neural Representations at Moments of Gaze Reinstatement

Eye movements originally made during memory formation are often spontaneously reproduced during retrieval, even in the absence of visual input, directing gaze back to the locations where goal-relevant episodic information was previously encountered. This behavior, known as gaze reinstatement, is thought to support the reactivation of episodic content associated with those locations (e.g., Johansso

Investigating creatine addiction and the potential of SLC6A8 inhibition in squamous cell lung cancer cell lines

Kan kreatinmetabolismen vara ett potentiellt behandlingsmål för lungcancer i skivepitel? Lungcancer är en av världens vanligaste typer av cancer. Varje år rapporteras över 2 miljoner nya lungcancer fall och 1,8 miljoner dödsfall i världen enligt statistik från 2022. Cancer uppstår som en konsekvens av både arv och miljö. Den vanligaste orsaken till lungcancer är rökning. De två vanligaste typerLung cancer is one of the most common cancer types and the leading cause of cancer-related mortality. Squamous cell carcinoma (SqCC) of the lung is the second most common histological subtype of lung cancer and the most prevalent in smokers. It is aggressive and hard to treat due to a lack of identified driver mutations and unresponsiveness to treatment. Finding new targeted therapies for SqCC is

A scalable all-digital near-memory computing architecture for edge AIoT applications

With the growing need to process large volumes of data, edge computing near data collection sources has become increasingly important. However, the resource constraints of edge devices require more efficient data processing techniques. Near-memory computing (NMC) presents an efficient solution, especially for data-intensive applications, by enabling processing that is both energy-efficient and har

On Minimax Optimal Dual Control for Fully Actuated Systems

A multi-variable adaptive controller is derived as the explicit solution to a minimax dynamic game. The minimizing player selects the control action as a function of past state measurements and inputs. The maximizing player selects disturbances and model parameters for the underlying linear time-invariant dynamics. This leads to a Bellman equation that can be solved explicitly for the case with un

Thalassa : Transforming Symbolic PDEs into Tensor-Based Solvers Running on ML Accelerators

We introduce Thalassa, a framework designed to convert nonlinear systems of partial differential equations (PDEs) with a time-like component into tensor programs that solve these equations. These programs can run on GPUs as well as machine learning (ML) acceleration hardware, enabling scientific computing fields such as computational fluid dynamics, astrophysics, mechanics and biology to utilize a

Extended deadline crisis4

CRISIS4 | CALL FOR PAPERS 4TH INTERNATIONAL CONFERENCE ON CRISIS COMMUNICATION IN THE 21ST CENTURY OCTOBER 7–10, 2015 IN HELSINGBORG, SWEDEN 2 INTERSECTIONS 4th International Conference on Crisis Communication in the 21st Century October 7–10, 2015 in Helsingborg, Sweden Hosted by Lund University, Campus Helsingborg and the International Research Group on Crisis Communication (IRGoCC) Partner: Tem

https://www.isk.lu.se/en/sites/isk.lu.se.en/files/extended_deadline_crisis4.pdf - 2025-11-21

Kgmus inst eng

Programme Syllabus 1. IDENTIFICATION • Name of programme: Bachelor’s Programme in Music, Individual Programme • Scope of programme in higher education credits: 180 • Cycle: First • Programme code: KGMUS. Specialisation: INST. 2. DETAILS OF APPROVAL Syllabus approved by the Board of the Faculty of Fine and Performing Arts 18 October 2017. This syllabus is valid from the autumn semester 2017. 3. PRO

https://www.mhm.lu.se/en/sites/mhm.lu.se.en/files/kgmus_inst_eng.pdf - 2025-11-21

Newkgmus inst eng

Programme Syllabus 1. IDENTIFICATION • Name of programme: Bachelor’s Programme in Music, Individual Programme • Scope of programme in higher education credits: 180 • Cycle: First • Programme code: KGMUS. Specialisation: INST. 2. DETAILS OF APPROVAL Syllabus approved by the Board of the Faculty of Fine and Performing Arts 18 October 2017. This syllabus is valid from the autumn semester 2017. 3. PRO

https://www.mhm.lu.se/en/sites/mhm.lu.se.en/files/newkgmus_inst_eng.pdf - 2025-11-21

Annual report 2018 final

The IIIEE is an international and interdisciplinary centre within Lund University that advances knowledge on how to catalyse the transition to low-carbon and resource efficient economies. We focus on the design, application and evaluation of policies and business strategies and pro- vide support for decision makers by public and private actors - internationally, nationally and locally. Since its f

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/annual_report_2018_final.pdf - 2025-11-21

Course syllabus imen68 ssc

Course syllabus IMEN68 Course syllabus IMEN68 Course syllabus Exempel på hållbarhetslösningar - projektkurs Sustainability solutions in context - client project IMEN68, 10 credits, A (Second Cycle) Valid for: Decided by: PLED W Date of Decision: 2018-03-22 General Information Main field: Enviromental Management and Policy. Depth of study relative to the degree requirements: Second cycle, has secon

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/course_syllabus_imen68_ssc.pdf - 2025-11-21