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3,5 miljarder år gamla bakterier kan rädda våra vatten från metallutsläpp Långt innan det fanns syre i atmosfären så fanns bakterier som ”andades” svavel. I stället för att andas ut koldioxid andas dessa bakterier ut sulfid, en negativt laddad svaveljon som binder till metaller. På en avfallsanläggning utanför Hässleholm står en testanläggning där man forskar på att minska utsläppen av metaller tHässleholm Miljö who own the landfill site in Vankiva in southern Sweden are having difficulties in keeping their heavy metal emissions within the limits of their very strict permit. Today reduction is reached by chemical precipitation, but a more effective and environmentally friendly process is wanted. Biological heavy metal removal in leachate water, using sulfate reducing bacteria (SRB) and me

Klimatförändringar förväntas ha en stor inverkan jordens ekosystem i framtiden och till en viss grad har en sådan påverkan redan börjat märkas av. Exempelvis har man märkt att trädens lövknoppar brister ut allt tidigare om vårarna, samtidigt som vissa flyttfåglar väljer att stanna i Norden över de mildare vintrarna, i stället för att flytta till sydligare breddgrader. Det här är troligtvis en konsLegacy effects of spring temperature anomalies on seasonal productivities in northern ecosystems Direct and lagged effects from spring temperature anomalies for the time-period 2001-2018 have been investigated for northern ecosystems (> 30°N). Three different data sets of Gross Primary Production (GPP) estimates (GOSIF, NIRvGPP and FLUX GPP) have been used in tandem with concurrent climate data

This thesis is about the risk management of banks and how changes in regulatory capital charges can affect a borrower in the Swedish capital market. The thesis takes the perspective of a borrower but also explains how banks are affected by changes in regulatory capital requirements. The main focus is on changes in a borrower's situation and each of the parts in this presentation is intended to

The aim of the study was to explore the development of functioning impairments and symptom occurrence during the last months of life of advanced cancer patients. Self-reported data from 116 patients who all completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) at 3, 2 and 1 month before death were analysed. All functioning as

The aim of this study was to achieve realistic levels of two different types of aerosols commonly abundant in indoor environments in an experimental chamber intended for human exposure studies and aerosol characterization. The aerosols chosen were particles from candle lights (in particle number dominated by inorganic water soluble particles) and from ozone-terpene reactions (organic particles). T

Problemformulering: Hur påverkar de nya amerikanska rekommendationerna för goodwill en koncerns resultat- och balansräkning i jämförelse med de internationella rekommendationerna för goodwill? Vårt syfte med denna uppsats är att jämföra nuvarande internationella rekommendationer, IAS 22 och IAS 36, med de nya amerikanska rekommendationerna FAS 141 och FAS 142. Metod: Eftersom vi har gjort en jämfö

Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.Results: Most lung adenocar

Popular Abstract in Swedish Lera-vatten-systemet finns i stort sett överallt i vår omgivning. Syftet med denna avhandling är att identifiera och undersöka egenskaper hos leror som är av betydelse för deras inbördes växelverkan. Leror är sammansatta av två eller tre molekylära lager och får därför en relativt komplex fördelning av elektrostatiska laddningar. Denna fördelning förändras med olika betClays are the world’s most widely used natural material, however, little is known regarding the microstructure as well as the forces involved in clay-water interactions, and their influence on the swelling properties. The utilization of clay platelets is nowadays a key in a number of biological and industrial applications e.g. nuclear waste management. Bentonites from different natural sources an

Huntington disease (HD) is a fatal neurodegenerative disorder caused by expansion of a CAG repeat in the HD gene. Degeneration concentrating in the basal ganglia has been thought to account for the characteristic psychiatric symptoms, cognitive decline and motor dysfunction. However, the homeostatic control of emotions and metabolism are disturbed early in HD, and focused studies have identified a

Dopamine replacement for Parkinson's disease (PD) have seen three major iterations of improvements since the introduction of l-3,4-dihydroxyphenylalanine (l-DOPA) pharmacotherapy: dopamine receptor agonists, ex vivo gene transfer for cell transplantation and most recently in vivo gene therapy. In this chapter, we describe the principles behind viral vector-mediated enzyme replacement in PD. We foc

In Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be limited to the basal ganglia, but recent studies have suggested a more widespread pathology involving hypothalamic dysfunction. Here we tested the hypothesis that expression of mutant huntingtin in the hypothalamus causes metabolic abnormalities. First, we showed that bacterial a

Viral vector-mediated gene transfer utilizing adeno-associated viral vectors has recently entered clinical testing as a novel tool for delivery of therapeutic agents to the brain. Clinical trials in Parkinson's disease using adeno-associated viral vector-based gene therapy have shown the safety of the approach. Further efforts in this area will show if gene-based approaches can rival the therapeut

What does a sustainability project look like in the 21st century? Not the glossy version, but the naked truth? Tired of manicured, over-theorised accounts of the ‘musts’ and ‘shoulds’ of sustainability transitions, we got to the bottom of things; actually, to the very bottom of the project hierarchy: the individual. Our point of departure is that projects are nothing but temporarily interconnected

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (htt) gene. Neuropathology is most severe in the striatum and cerebral cortex. As mutant htt is ubiquitously expressed, it has not been possible to establish clear structure-to-function relationships for the clinical aspects. In the present study, we have injected recombinant adeno-as

Objective: To assessmyoepithelium with p63 in fresh breast cancer (BC)tissue samples collected in RNA later for further analysis with NextGeneration Sequencing (NGS) technique. For a better understanding ofthe NGS bulk-analysis, a central part of the sample in RNA-later isformalin-fixed paraffin-embedded to score relative cellularity in % onhematoxylin-eosin (HE) staining (% of invasive cancer, ca

Objective: Estrogen receptor (ER) positive breast cancer (BC) can havean insidious course with disease-relapse decades after primary surgery.New analysis performed on archived formalin-fixed paraffin-embedded(FFPE) tissue are important for disease-management in late BC-relapseand an important tool in BC-research. However, although loss of immunoreactivityin tissue slides after sectioning has been

Background: Presence of circulating tumor cells (CTCs) is a validated prognostic marker in metastatic breast cancer. Additional prognostic information may be obtained by morphologic characterization of CTCs. We explored whether apoptotic CTCs, CTC clusters and leukocytes attached to CTCs are associated with breast cancer subtype and prognosis at base-line (BL) and in follow-up (FU) blood samples i

Organisms in the wild are faced with multiple threats and a common response is a change in behaviour. To disentangle responses to several threats, we exposed two differently sized species of the freshwater invertebrate Daphnia to solar ultraviolet radiation (UVR) and predation from either moving pelagic or benthic ambush predators. Using an advanced nanotechnology-based method, we tracked the thre

Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2