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There is active crosstalk between tumor cells and the tumor microenvironment during metastatic progression, a process that is significantly affected by obesity, particularly in breast cancer. Here we analyze the impact of a high fat diet (HFD) on metastasis, focusing on the role of platelets in the formation of premetastatic niches (PMNs). We find that a HFD provokes pre-activation of platelets an

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Labile organic carbon is a major nutrient, controlling microbial activity in aquatic ecosystems and contributing to the global cycling of carbon. During the production and distribution of drinking water, labile carbon fractions often escape treatment, which threatens water quality and biostability. This study proposes and compares two rapid methods for monitoring the production and removal of labi

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Background: Developmental exposures to neurotoxic insecticides, as pyrethroids and chlorpyrifos are of growing concern. Objective: To study associations between low prenatal and childhood exposure to pyrethroids and chlorpyrifos and motor skills at age 7. Materials and methods: Data consisted of sub-samples of women and children from the Odense Child Cohort; 883 mother-child pairs with maternal ur

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This article highlights the restructuring of the Swedish welfare state through looking at how a humanitarian logic has entered civil society at a local level around the issue of precarious housing for unaccompanied youth. Drawing on existing literature on ‘humanitarian reason’ (Fassin 2011) and ‘humanitarian citizenship’ (Cabot 2019), the article explores the 2019 ‘crisis’ affecting unaccompanied

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Logs are prevalent in modern cloud systems and serve as a valuable source of information for system maintenance. Over the years, many supervised, semi-supervised, and unsupervised log analysis methods have been proposed to detect system anomalies. In particular, semi-supervised methods have garnered increasing attention as they balance reduced labeled data requirements and optimal detection perfor

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Boreal rivers and streams are significant sources of carbon dioxide (CO2) and methane (CH4) for the atmosphere. Yet the controls and the magnitude of these emissions remain highly uncertain, as current estimates are mostly based on indirect and discrete flux measurements. In this study, we present and analyse the longest CO2 and the first ever CH4 flux dataset measured by the eddy covariance (EC)

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This chapter examines the integration of VR in teaching, focusing on teachers' experiences, perceptions, and challenges. Using a mixed-methods approach, qualitative data from 156 teachers were analyzed with NLP and AI-driven models. The findings show that VR enhances student engagement, motivation, and experiential learning by making abstract concepts accessible and providing risk-free environment

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The rate of colorectal anastomotic leakage has remained unchanged for the last decades. The limitations of current anastomotic methods have generated an interest in alternative anastomotic techniques, such as compression anastomosis. The aim of this experimental study was to evaluate the early mechanical strength in left colonic anastomoses, comparing C-REX LapAid and circular stapled anasto

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OBJECTIVE: Infective native aneurysms of the femoropopliteal arteries (INA-FPs) are rare and mostly reported in intravenous drug users (IVDU). This study aimed to summarize all cases of INA-FPs presented in the literature, to describe patient characteristics, microbiology, treatments and outcomes, and compare IVDU with non-IVDU patients.METHODS: A systematic search of PubMed, ScienceDirect, Embase

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Iridescence refers to the optical property of surfaces for which the reflected wavelengths depend on viewing geometry. Although iridescence underlies some of the most striking animal colours, the sensory stimulation elicited by iridescent spectral shifts in relevant observers has seldom been explored. Wall lizards (genus Podarcis), with remarkable intraspecific colour variation and possible irides

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Pixel sensors in 3D technology equip the outer ends of the staves of the Insertable B Layer (IBL), the innermost layer of the ATLAS Pixel Detector, which was installed before the start of LHC Run 2 in 2015. 3D pixel sensors are expected to exhibit more tolerance to radiation damage and are the technology of choice for the innermost layer in the ATLAS tracker upgrade for the HL-LHC programme. While

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Objectives: Aidarken is a region with mercury production from cinnabar and, to a lesser extent, from mercury-antimony-fluorite and waste recycling. Recent smelting emissions of elemental Hg vapour are low; however, combined with past pollution legacies, anaemia and iodine deficiency, the health effects for vulnerable populations are still possible. The study aimed to evaluate metal(loid)s status i

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Finding local features that are repeatable across multiple views is a cornerstone of sparse 3D reconstruction. The classical image matching paradigm detects keypoints per-image once and for all, which can yield poorly-localized features and propagate large errors to the final geometry. In this article, we refine two key steps of structure-from-motion by a direct alignment of low-level image inform

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Human diets play a crucial role in both human health and environmental sustainability. In 2019, the EAT-Lancet Commission on healthy diets from sustainable food systems introduced the EAT-Lancet planetary health diet, a universal reference diet designed to promote human health while minimizing environmental degradation. It is a predominantly plant-based dietary pattern, rich in whole grains, veget

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Outbreaks of highly pathogenic avian influenza (HPAI) have intensified over the last decade, spotlighting the concept of “epicentre” as a means of locating disease origins. Although epicentre thinking can facilitate rapid interventions, it often overlooks the political-economic and ecological forces driving outbreaks. Drawing on critical geography, political ecology, and global supply chain analys

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Values, worldviews, and self-construal are strong correlates of pro-environmental behavior. In this brief empirical note, we argue that these constructs overlap conceptually and share underlying dimensions. Using an international sample of 11,964 individuals, we demonstrate that values, worldviews, and self-construal can be reduced to two dimensions, self-focus and other-focus, capturing 67 % of v

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Shallow geothermal offers great potential to supply emission-free heating and cooling and has therefore a pivotal role in the transition of heating and cooling networks. This paper presents a novel heating and cooling network with possible geothermal energy sharing between decentralized borefields located at each building level. The system consolidates the benefits of both standalone and centraliz