Filtyp
Priming of insulin secretory granules for release requires intragranular acidification and depends on vesicular Cl(-)-fluxes, but the identity of the chloride transporter/ion channel involved is unknown. We tested the hypothesis that the chloride transport protein ClC-3 fulfills these actions in pancreatic beta cells. In ClC-3(-/-) mice, insulin secretion evoked by membrane depolarization (high ex
Denna uppsats handlar om miljöskador som uppkommer till följd av krig. Det finns miljöskador som inte går att avgränsa i tid eftersom de har långvariga effekter. I folkrätten är miljöskador svåra att definiera. Frågeställningen är centrerad runt skadebegreppet i förhållande till statsansvaret, främst med fokus på om apparaten i dagsläget för att genomdriva ansvar är för trubbig för ändamålet. Vida
Trots att amning har stora hälsoeffekter har Sverige en sjunkande amningsstatik. Syftet med studien var att beskriva förstagångsmödrars attityder till amning, deras självtillit i amningsfrågor samt undersöka samband mellan attityder, självtillit och omfattning av amning. Vidare att undersöka deras åsikter om amningsinformation i vårdkedjan. Metoden var en prospektiv tvärsnittsstudie med en kvantit
Studiens syfte var att undersöka om det fanns någon skillnad mellan en grupp patienter med schizofrenidiagnos och en jämförelsegrupp bestående av personal från en akutpsykosavdelning när det gäller mentaliseringsförmåga. Mentaliseringsförmågan skattades med instrumentet ”Reading the Mind in the Eyes Test (RMET)”. Den ursprungliga planen var att konsekutivt rekrytera samtliga patienter till studien
Syftet med studien var att beskriva och analysera ett framväxande fenomen – samhällsentreprenörskap – för att öka förståelsen för dess betydelse i ett svenskt sammanhang. Studien är utformad som en kvalitativ fallstudie med en abduktiv ansats, där det empiriska materialet och det teoretiska ramverket påverkat varandra om vartannat. Studiens teoretiska ramverk består av en modell vid namn ”The Soci
Civil wars continue to prevail, and the number of causalities increase in the last decade, while socioeconomic disparities within countries steadily widen in many parts of the world. Yet, the understanding of the potential correlations between these two trends remains incomplete. This thesis aims to probe this relationship by studying what effect socioeconomic inequality has on conflict intensity.
This study maps the intersection of homelessness and migration in Europe by focusing on Italy and Sweden; in the study, ‘Europe’ is defined by the Schengen Common Area Agreement, by the Common European Asylum System and by the Dublin Regulation. Using Kimberlé Crenshaw’s Intersectionality as one of its main theoretical reference points, the study argues that different dimensions of power relations
Denna rapport behandlar väg E6 mellan Helsingborg-Vellinge med avseende på omkörningsförbudet för tung trafik som infördes den 18e mars år 2019. Väg E6 genom hela Skåne har under en lång tid präglats av trafiksäkerhets- och framkomlighetsproblem. Denna rapport skrevs i syfte att utreda på vilka sätt omkörningsförbudet påverkat just dessa faktorerna, d.v.s. framkomlighet och trafiksäkerhet. För attThis report deals with road E6 between Helsingborg-Vellinge and regards the overtaking prohibition for heavy traffic which was introduced on the 18th of March 2019. Road E6 through Skåne has during a long period been affected by traffic safety and availability issues. This report was written with the purpose of examining in what ways the overtaking prohibition has affected these factors, meaning a
This thesis aimed to work with different techniques of building archaeology, both traditional and digital. The goal was to define the possibilities offered by the “traditional” and the “digital” building archaeology but also to show the limits of these two methods. The main issue of discussing methodological problems in building archaeology was the need to define digital building archaeology, espe
Jag har analyserat huvud- och spårelementkoncentrationer i plagioklas från en norit-anortositintrusion, Älgön, Hakefjorden vid Sveriges västkust med syfte att fastställa intrusionens magmatiska ursprung, magmans utveckling och dess transport upp genom jordskorpan. Megakrister av plagioklas i anortositen har en homogen fördelning med avseende på huvud- och spårelement medan plagioklas-megakrister iMajor and trace element data taken from plagioclase crystals from anorthosites and related rock units in the Hakefjorden Complex located off the west coast of Sweden were investigated for the purposes of constraining magma chamber processes and the source of the magma. Although the anorthosite units were completely homogenous in regards to its chemistry, the plagioclase in the associated norite an
We report on the multi-wavelength observations of PKS 1510-089 (a flat spectrum radio quasar (FSRQ) at z = 0.361) during its high activity period between 2008 September and 2009 June. During this 11 month period, the source was characterized by a complex variability at optical, UV, and gamma-ray bands, on timescales down to 6-12 hr. The brightest gamma-ray isotropic luminosity, recorded on 2009 Ma
Understanding tree recruitment is needed to forecast future forest distribution. Many studies have reported the relevant ecological factors that affect recruitment success in trees, but the potential for genetic-based differences in recruitment has often been neglected. In this study, we established a semi-natural reciprocal sowing experiment to test for local adaptation and microenvironment effec
The aim of this study was to achieve realistic levels of two different types of aerosols commonly abundant in indoor environments in an experimental chamber intended for human exposure studies and aerosol characterization. The aerosols chosen were particles from candle lights (in particle number dominated by inorganic water soluble particles) and from ozone-terpene reactions (organic particles). T
Background: Dairy proteins, in particular the whey fraction, exert insulinogenic properties and facilitate glycemic regulation through a mechanism involving elevation of certain plasma amino acids, and stimulation of incretins. Human milk is rich in whey protein and has not been investigated in this respect. Method: Nine healthy volunteers were served test meals consisting of human milk, bovine mi
The Brain-Expressed X-linked (BEX) family proteins are comprised of five human proteins including BEX1, BEX2, BEX3, BEX4 and BEX5. BEX family proteins are expressed in a wide range of tissues and are known to play a role in neuronal development. Recent studies suggest a role of BEX family proteins in cancers. BEX1 expression is lost in a subgroup of patients with acute myeloid leukemia (AML) and c
Seasonal patterns in assimilation of externally produced, allochthonous, organic matter into aquatic food webs are poorly understood, especially in brown-water lakes. We studied the allochthony (share biomass of terrestrial origin) in cladoceran, calanoid and cyclopoid micro-crustacean zooplankton from late winter to fall during two years in a small humic lake (Sweden). The use of allochthonous re
Background: Epidemiologic evidence of an association between fish intake and type 2 diabetes (T2D) is inconsistent and unresolved. Objective: The objective was to examine the association between total and type of fish intake and T2D in 8 European countries. Design: This was a case-cohort study, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with 3.99 m
Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. Targeting of the adaptive responses of cancer cells to hypoxia offers opportunities for tumour specific therapies. The aim of this
