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Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the
Breast cancer and melanoma metastasize predominantly via the lymphatic route. It has long been known that invasion into one or a few nodes draining the primary tumour, the sentinel nodes (SN), is the most important, early sign of dissemination. If no malignant cells are detected in the SN, dissemination is unlikely to be expected. For the last 10 years SN biopsy has become an important tool in sta
Background:In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and treatment: estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (ERBB2/HER2), Ki67, and Nottingham histological grade (NHG). We aimed to develop classifiers for these biomarkers based on tumor mRNA-sequencing (RNA
Objective:: Our aim was to explore the presence of symptoms, symptom relief, and other key aspects of palliative care during the final week of life among older people residing in nursing homes. Method:: Our study employed data from the Swedish Palliative Care Register on all registered individuals aged 60 and older who had died in nursing homes during the years 2011 and 2012. Variables pertaining
BACKGROUND Madagascar is the fourth biggest island and one of the poorest countries in the world, with more than 75 % of the 24 million inhabitants living under poverty line. The health care system in the country is under development, as well as the field of rehabilitation services and the area of prosthetic and orthotic services in specific. There is very limited published research concerning reh
Background Clinical egg allergy is a common food allergy. Current management relies upon strict allergen avoidance. Oral immunotherapy (OIT) might be an optional treatment, through desensitization to egg allergen. Objectives We aimed to assess the successful desensitization and development of tolerance to egg protein and the safety of egg oral and sublingual immunotherapy in children and adults wi
Spatial data are playing an increasingly important role in watershed science and management. Large investments have been made by government agencies to provide nationally-available spatial databases; however, their relevance and suitability for local watershed applications is largely unscrutinized. We investigated how goodness of fit and predictive accuracy of total phosphorus (TP) concentration m
Migratory routes and remote wintering quarters in birds are often species and even population specific. It has been known for decades that songbirds mainly migrate solitarily, and that the migration direction is genetically controlled. Yet, the underlying genetic mechanisms remain unknown. To investigate the genetic basis of migration direction, we track genotyped willow warblers Phylloscopus troc
Background: The members of the Task Force on Contact Dermatitis and the Task Force on Occupational Dermatoses of the European Academy of Dermatology and Venereology (EADV), of the European Dermatology Forum (EDF), and the members of the UEMS Section of Dermatology-Venereology (UEMS-EBDV) we want to vindicate the fundamental role that the specialist in Dermatology has in the diagnosis and managemen
Dnr STYR 2021/2184 Framtidens ledarskapsutveckling vid Lunds universitet Slutrapport av Maria Flores Andreas Bryngelson 2 Sammanfattning Nyligen genomförda utredningar och utvärderingar visar att ledarskapet vid Lunds universitet är ett utvecklingsområde som kan bidra till framstående forskning, utbildning och samverkan samt medarbetares hälsa och välbefinnande. Vid Lunds universitet genomfördes d
Strategizing: planning and processes 2017-10-12 1 AFFÄRSMODELLER FÖR ÖKAD HÅLLBARHET Ett forskarperspektiv Herman Stål 2017-10-12 Studier i samarbete med H Corvellec, Lunds universitet • Ekonomin inkräktar på allt fler områden o Absoluta försämringar Klimatförändringar Biologisk mångfald Vattentillgång o Ökande ojämlikhet Inom/mellan länder • Samtidigt engagerar sig alltfler företag för hå
https://www.ses.lu.se/sites/ses.lu.se/files/stal_171010_hallbarhetsdag_0.pdf - 2026-07-09
Utvecklingsplan för forskarutbildningarna inom kulturgeografi och ekonomisk geografi samt humanekologi Sida 1 av 7 Fakultetsstyrelsen UTVECKLINGSPLAN Diarienummer STYR 2023/22 2024-06-13 Utvecklingsplan för forskarutbildningarna inom kulturgeografi och ekonomisk geografi samt humanekologi Bakgrund Forskarutbildningarna i kulturgeografi och ekonomisk geografi samt humanekologi vid Institutionen för
https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2024-08/utvecklingsplan-forskarutbildning-keg-hek.pdf - 2026-07-09
Background: The 2030 agenda for sustainable development calls upon all nations to make critical investments in their health systems to deliver universal access to Sexual and Reproductive Health and Rights (SRHR). Capacity development is listed among the strategies for achieving sustainable development goals. Although capacity development has been a major component of international development for
Aim: This randomised controlled trial evaluated changes in parental self-efficacy and children's weight, after a Child-Centred Health Dialogue about preventing obesity. Methods: We randomly assigned 37 Child Health Centres in Skåne county Sweden to provide usual care or the dialogue intervention. They included centres from high and low socioeconomic areas. The outcomes were changes in parental sel
Effectively identifying deviations in real-world medical time-series data is a critical endeavor, essential for early surveillance of disease outbreaks. This paper demonstrates the integration of time-series anomaly detection techniques to develop surveillance systems for disease outbreaks. Utilizing data from Sweden's telephone counseling service (1177), we first illustrate the trends in physical
Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, n
