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This report summarises our efforts in deriving, characterising and banking of 20 different human embryonic stem cell lines. We have derived a large number of human embryonic stem cell lines between 2001 and 2005. One of these cell lines was established under totally xeno-free culture conditions. In addition, several subclones have been established, including a karyoptypical normal clone from a tri
Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk
Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc). Methods Patients with SSc (n=5860) fulfilling the American College of Rheumatology criteria and prospectively followed in the EULAR Scleroderma Trials and Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause of death and comorbidities. Kaplan-Meier and Cox pro
Malignant fibrous histiocytoma (MFH) and fibrosarcoma (FS) of bone are rare malignant tumours and contentious entities. Sixty seven cases labelled as bone MFH (57) and bone FS (10) were retrieved from five bone tumour referral centres and reviewed to determine whether recent advances allowed for reclassification and identification of histological subgroups with distinct clinical behaviour. A panel
The construction sector has been criticised in recent years for being inefficient. The critique involved describes finished buildings as having flaws and there being a lack of interest within the construction sector in assembling knowledge and sharing experience. The construction industry has started working with questions of how efficiency can be increased by reducing the errors made. Knowledge
A detailed study of ultraviolet spectra of the symbiotic star AG Peg has been undertaken to derive the atomic excitation mechanisms and origin of formation for the lines common in symbiotic systems. More than 600 emission lines are observed in spectra from IUE, HST and FUSE of which 585 are identified. Population mechanisms and origin of formation are given for a majority of those lines. Based on
The release gamma-aminobutyric acid (GABA) and ATP from rat beta cells was monitored using an electrophysiological assay based on overexpression GABAA or P2X2 receptor ion channels. Exocytosis of LDCVs, detected by carbon fiber amperometry of serotonin, correlated strongly (similar to 80%) with ATP release. The increase in membrane capacitance per ATP release event was 3.4 fF, close to the expecte
Popular Abstract in Swedish I Sverige har andelen förtidspensionärer ökat under lång tid och uppgick år 1998 till 7.6% av befolkningen i arbetsför ålder (16-64 år). Den vanligaste orsaken till att en individ förtidspensioneras är reducerad arbetsförmåga till följd av problem i rörelseorganen. Kunskaperna om förtidspensionärers livskvalitet är bristfälliga. Syftet med denna studie var att studera lThe starting-point of this thesis was the high rate of disability pensioners in Sweden and the lack of knowledge about what a disability pension entails for quality of life (QL). The aim of the study was to gain knowledge about QL among disability retirees with musculoskeletal disorders (ERPs). A questionnaire was sent in 1992 to 450 ERPs in Kristianstad Municipality, Sweden, granted their disabil
OBJECTIVE: To characterize the clinical phenotype, with emphasis on electrophysiology and blood flow measurements, of a family with dominant optic nerve atrophy and an identified mutation in the OPA1 gene. METHODS: Seven family members were examined. Ophthalmological evaluation included testing of visual acuity, ophthalmolscopy, kinetic perimetry, color vision testing, full-field electroretinograp
Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer
The cost of energy for drying paper is substantial for the pulp and paper industry, and studies of various strategies for energy cost reductions such as increased energy efficiency, increased heat recovery from the exhaust drying air and reduced cost of the process heat are presented in this thesis. The energy use and cost studies were performed using a block-model based simulation tool developed
Popular Abstract in Swedish Användningen av informations och kommunikationsteknik (IKT eller IT) påverkar vårt sätt att kommunicera i arbetslivet. Det underlättar distansarbete och skapar möjligheter till s.k. virtuella möten - att samarbeta utan att träffas fysiskt. Detta kan i sin tur påverka behovet av pendlings- och tjänsteresor, genom att vi får tillgång information, en funktion eller en tjänInformation and Communication Technologies change the way we work and communicate, enabling us to telework and to have virtual meetings - collaborating without a physical meeting. This can influence the need for commuting and business travel by provision of access to an activity without mobility - virtual mobility. The large environmental impact of travel makes this potential travel reduction inte
Nitro blue tetrazolium (NBT) staining in normal rat retina was previously found to be affected by inhibition of free radical-related enzyme systems, indicating that NBT might be useful as a marker of free radicals. The aim of the present study was to investigate NBT staining in rat retina in vitamin E deficiency and after blue light exposure, and also to measure hydrogen peroxide (H2O2) production
PURPOSE: To measure the apparent diffusion coefficient (ADC) of hyperpolarized (HP) (3)He gas using diffusion weighted MRI in healthy volunteers and patients with emphysema and examine the reproducibility and volume dependency. MATERIALS AND METHODS: A total of eight healthy volunteers and 16 patients with emphysema were examined after inhalation of HP (3)He gas mixed with nitrogen (N(2)) during b
The Trier Social Stress Test (TSST) is a widely used protocol to induce stress in laboratory settings. Briefly, in the TSST, the test participant is asked to hold a speech and to do an arithmetic task in front of an audience. In the present pilot study, we examined endocrine and autonomic reactivity and habituation to repeated stress provocations using a virtual reality (VR) version of TSST. The V
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Skivepitelcancer i huvud- och halsregionen (SCCHN) Kliniska aspekter Prognosen vid SCCHN är i stort sett oförändrat dålig sedan 30 år tillbaka; cirka hälften av patienterna dör av sin sjukdom. Trots stora tekniska framsteg kring behandlingsteknikerna (ofta en kombination av kirurgi, strål- och i viss mån cellgiftsbehandling) medför dAt present, clinical outcome or response to therapy can not be fully predicted in individual cases of squamous cell carcinoma of the head and neck (SCCHN). The overall aim of the present studies was to investigate potential prognostic factors, more closely related to the malignant progression of a tumor than the established markers, such as the TNM-classification system. Tumor samples were investi
